Circulation, Vol 88, 405-415, Copyright © 1993 by American Heart Association
SC Smart, S Sawada, T Ryan, D Segar, L Atherton, K Berkovitz, PD Bourdillon and H Feigenbaum
BACKGROUND. Dysfunction after thrombolytic therapy of acute myocardial
infarction (MI) may be reversible. Early after myocardial infarction, both
reversible and irreversible injury may be manifested by regional wall
motion abnormalities. Improved wall thickening during dobutamine infusion
(dobutamine-responsive wall motion) may accurately identify reversibly
injured segments. METHODS AND RESULTS. To determine whether
dobutamine-responsive wall motion accurately detects reversible
postischemic dysfunction irrespective of infarct location, multistage
(baseline, 4 and 12 micrograms.kg-1.min-1, and peak) dobutamine
echocardiography (DE) was performed within 7 days of thrombolytic therapy.
Resting echocardiography was repeated > or = 4 weeks after MI, and
reversible dysfunction was defined as improved wall motion. The accuracy of
dobutamine-responsive wall motion was compared with that of signs of early
reperfusion, non-Q-wave MI, and peak creatine kinase (CK). Sixty-three
patients underwent DE without complications. Follow- up echocardiograms
were done in 51 (81%) of these patients, and wall motion improved in 22
(41%). Dobutamine-responsive wall motion during all stages of DE was very
specific for reversible dysfunction (90% to 93%) but sensitive (86%) only
when hemodynamics were not altered (low dose, 4 micrograms.kg-1.min-1).
Non-Q-wave MI and a low peak CK (< 1000 IU/mL) were also specific (89%
to 93%) but less sensitive (64% [P = .16] and 55% [P < .05],
respectively). Signs of early reperfusion did not identify postischemic
dysfunction. Low-dose dobutamine-responsive wall motion and non-Q-wave MI
independently identified reversible dysfunction, but only
dobutamine-responsive wall motion was sensitive in all infarct locations.
Non-Q-wave MI was sensitive only in anterior infarction. CONCLUSIONS.
Multistage dobutamine echocardiography can be performed safely early after
thrombolytic therapy. Low-dose dobutamine- responsive wall motion
accurately detected reversible dysfunction in all infarct locations.
Dobutamine-responsive wall motion and non-Q-wave infarction may be very
useful for accurately identifying reversible dysfunction early after
thrombolytic therapy for acute MI.
ARTICLES
Low-dose dobutamine echocardiography detects reversible dysfunction after thrombolytic therapy of acute myocardial infarction
Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis.
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