Circulation, Vol 89, 1982-1991, Copyright © 1994 by American Heart Association
JT Flaherty, B Pitt, JW Gruber, RR Heuser, DA Rothbaum, LR Burwell, BS George, DJ Kereiakes, D Deitchman and N Gustafson
BACKGROUND: Animal studies have demonstrated a burst of oxygen free radical
generation after reperfusion of ischemic myocardium that could be blocked
by administration of the free radical scavenger recombinant human
superoxide dismutase (h-SOD). A multicenter, randomized, placebo-
controlled clinical trial was designed to test the hypothesis that free
radical-mediated reperfusion injury could be reduced by intravenous
administration of h-SOD begun before percutaneous transluminal coronary
angioplasty (PTCA) in patients with acute transmural myocardial infarction.
METHODS AND RESULTS: One hundred twenty patients were randomized to receive
placebo (n = 59) or h-SOD (n = 61) given as a 10- mg/kg intravenous bolus
followed by a 60-minute infusion of 0.2 mg.kg- 1.min-1. Left ventricular
function was analyzed via paired contrast left ventriculograms performed
before PTCA and after 6 to 10 days and paired radionuclide ventriculograms
performed within 24 hours of PTCA and after 4 to 6 weeks. Both h-SOD- and
placebo-treated patients showed improvement in global and regional left
ventricular function after successful reperfusion. Compared with the
placebo group, no additional improvement was observed in the patients
treated with h-SOD. CONCLUSIONS: The results of this clinical trial failed
to demonstrate a beneficial effect of h-SOD on global or regional left
ventricular function in patients who underwent successful PTCA for
treatment of acute myocardial infarction.
ARTICLES
Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction
Johns Hopkins Medical Institutions, Baltimore, Md.
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