Circulation, Vol 89, 2070-2078, Copyright © 1994 by American Heart Association
WJ Paulus, PJ Vantrimpont and AM Shah
BACKGROUND: In isolated mammalian cardiomyocytes, papillary muscle
preparations, and ejecting hearts, nitric oxide (NO) or other cyclic
GMP-elevating interventions increase diastolic cell length and reduce peak
contractile performance by hastening onset of myocardial relaxation. In the
present study, the effect of NO on left ventricular (LV) relaxation and
diastolic distensibility was investigated in humans. METHODS AND RESULTS:
The NO donor substance sodium nitroprusside was infused during cardiac
catheterization in the global coronary bed of the LV of patients (n = 13)
investigated for chest pain who were without evidence of obstructive
coronary artery or other cardiac disease. Sodium nitroprusside was infused
intracoronarily at a dosage (< or = 4 micrograms/min) that was
previously shown to be devoid of systemic effects when infused into the
brachial artery to investigate the reactivity of the forearm vascular bed.
The effect of this global intracoronary infusion of the NO donor sodium
nitroprusside was assessed by sequential LV angiograms and
tip-micromanometer pressure recordings. During global intracoronary
nitroprusside infusion, there was a decrease in heart rate from 78 +/- 11
to 76 +/- 12 beats per minute (P < .05), in LV peak systolic pressure
from 161 +/- 18 to 146 +/- 18 mm Hg (P < .001), and in time to onset of
LV relaxation (interval from Q wave on the ECG to LV dP/dtmin) from 432 +/-
36 to 419 +/- 36 milliseconds (P < .01). In 7 patients in whom adequate
sequential LV angiograms could be obtained, LV end-diastolic volume
increased from 158 +/- 34 to 165 +/- 40 mL (P < .05), whereas LV end-
diastolic pressure fell from 18 +/- 5 to 12 +/- 3 mm Hg (P < .02), and
in 5 of these 7 patients, a downward shift of the diastolic LV pressure-
volume relation was observed. In 5 patients, a right atrial infusion of
sodium nitroprusside was performed either before (n = 2) or after the
global intracoronary infusion. The decrease in LV peak systolic pressure
observed during right atrial infusion was significantly smaller (P <
.01) than during global intracoronary infusion. CONCLUSIONS: The present
study reveals reduced LV pressure development, an LV relaxation-hastening
effect, and improved LV diastolic distensibility during global
intracoronary infusion of the NO donor substance sodium nitroprusside.
These effects appeared to be unrelated to systemic vasodilation or to
pericardial constraint and could be explained by a direct myocardial effect
of NO, probably through activation of guanylyl cyclase to increase cyclic
GMP or through modification of other cellular proteins.
ARTICLES
Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion
Cardiovascular Center, O.L.V. Ziekenhuis, Aalst, Belgium.
This article has been cited by other articles:
 |
|
 |
|
  M. Seddon, A. M. Shah, and B. Casadei Cardiomyocytes as effectors of nitric oxide signalling Cardiovasc Res, July 15, 2007; 75(2): 315 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Weber, J Auer, M F O'Rourke, C Punzengruber, E Kvas, and B Eber Prolonged mechanical systole and increased arterial wave reflections in diastolic dysfunction Heart, November 1, 2006; 92(11): 1616 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rassaf, L. W. Poll, P. Brouzos, T. Lauer, M. Totzeck, P. Kleinbongard, P. Gharini, K. Andersen, R. Schulz, G. Heusch, et al. Positive effects of nitric oxide on left ventricular function in humans Eur. Heart J., July 2, 2006; 27(14): 1699 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Parent, N. Leblanc, and M. Lavallee Nitroglycerin reduces myocardial oxygen consumption during exercise despite vascular tolerance Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1226 - H1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hauser, H. Bracht, M. Matejovic, P. Radermacher, and B. Venkatesh Nitric Oxide Synthase Inhibition in Sepsis? Lessons Learned from Large-Animal Studies Anesth. Analg., August 1, 2005; 101(2): 488 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ruetten, S. Dimmeler, D. Gehring, C. Ihling, and A. M. Zeiher Concentric left ventricular remodeling in endothelial nitric oxide synthase knockout mice by chronic pressure overload Cardiovasc Res, June 1, 2005; 66(3): 444 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Layland, R. J. Solaro, and A. M. Shah Regulation of cardiac contractile function by troponin I phosphorylation Cardiovasc Res, April 1, 2005; 66(1): 12 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. B. Popovic, U. N. Khot, G. M. Novaro, F. Casas, N. L. Greenberg, M. J. Garcia, G. S. Francis, and J. D. Thomas Effects of sodium nitroprusside in aortic stenosis associated with severe heart failure: pressure-volume loop analysis using a numerical model Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H416 - H423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Bendall, T. Damy, P. Ratajczak, X. Loyer, V. Monceau, I. Marty, P. Milliez, E. Robidel, F. Marotte, J.-L. Samuel, et al. Role of Myocardial Neuronal Nitric Oxide Synthase-Derived Nitric Oxide in {beta}-Adrenergic Hyporesponsiveness After Myocardial Infarction-Induced Heart Failure in Rat Circulation, October 19, 2004; 110(16): 2368 - 2375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Leite-Moreira and C. Bras-Silva Inotropic effects of ETB receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1194 - H1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rodriguez, B. Molino, H. R. Weiss, and P. M. Scholz Negative metabolic and coronary flow effects of decreases in cAMP and increases in cGMP in control and renal hypertensive rabbit hearts J Appl Physiol, July 1, 2004; 97(1): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Paulus and J. G. F. Bronzwaer Nitric oxide's role in the heart: control of beating or breathing? Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H8 - H13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Adler, H. Huang, Z. Wang, J. Conetta, E. Levee, X. Zhang, and T. H. Hintze Endocardial endothelium in the avascular frog heart: role for diffusion of NO in control of cardiac O2 consumption Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H14 - H21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Prabhu Nitric Oxide Protects Against Pathological Ventricular Remodeling: Reconsideration of the Role of NO in the Failing Heart Circ. Res., May 14, 2004; 94(9): 1155 - 1157. [Full Text] [PDF]
|
|
|
|
|
|
D. A. Wink, K. M. Miranda, T. Katori, D. Mancardi, D. D. Thomas, L. Ridnour, M. G. Espey, M. Feelisch, C. A. Colton, J. M. Fukuto, et al. Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2264 - H2276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Godecke, A. Molojavyi, J. Heger, U. Flogel, Z. Ding, C. Jacoby, and J. Schrader Myoglobin Protects the Heart from Inducible Nitric-oxide Synthase (iNOS)-mediated Nitrosative Stress J. Biol. Chem., June 6, 2003; 278(24): 21761 - 21766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Brutsaert Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity Physiol Rev, January 1, 2003; 83(1): 59 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. F. Bronzwaer, C. Heymes, C. A. Visser, and W. J. Paulus Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H10 - H16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Kaye, M. M. Parnell, and B. A. Ahlers Reduced Myocardial and Systemic L-Arginine Uptake in Heart Failure Circ. Res., December 13, 2002; 91(12): 1198 - 1203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M Cotton, M T Kearney, and A M Shah Nitric oxide and myocardial function in heart failure: friend or foe? Heart, December 1, 2002; 88(6): 564 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mebazaa, G. W. De Keulenaer, X. Paqueron, L. J. Andries, P. Ratajczak, S. Lanone, C. Frelin, D. Longrois, D. Payen, D. L. Brutsaert, et al. Activation of Cardiac Endothelium as a Compensatory Component in Endotoxin-Induced Cardiomyopathy: Role of Endothelin, Prostaglandins, and Nitric Oxide Circulation, December 18, 2001; 104(25): 3137 - 3144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. MacCarthy, D. J. Grieve, J.-M. Li, C. Dunster, F. J. Kelly, and A. M. Shah Impaired Endothelial Regulation of Ventricular Relaxation in Cardiac Hypertrophy: Role of Reactive Oxygen Species and NADPH Oxidase Circulation, December 11, 2001; 104(24): 2967 - 2974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Paulus, S. Frantz, and R. A. Kelly Nitric Oxide and Cardiac Contractility in Human Heart Failure: Time for Reappraisal Circulation, November 6, 2001; 104(19): 2260 - 2262. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cotton, M. T. Kearney, P. A. MacCarthy, R. M. Grocott-Mason, D. R. McClean, C. Heymes, P. J. Richardson, and A. M. Shah Effects of Nitric Oxide Synthase Inhibition on Basal Function and the Force-Frequency Relationship in the Normal and Failing Human Heart In Vivo Circulation, November 6, 2001; 104(19): 2318 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Weaver and S. Churchill Pulmonary Edema Associated With Hyperbaric Oxygen Therapy Chest, October 1, 2001; 120(4): 1407 - 1409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R D Rakhit and M S Marber Nitric oxide: an emerging role in cardioprotection? Heart, October 1, 2001; 86(4): 368 - 372. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Paolocci, W. F. Saavedra, K. M. Miranda, C. Martignani, T. Isoda, J. M. Hare, M. G. Espey, J. M. Fukuto, M. Feelisch, D. A. Wink, et al. Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling PNAS, August 17, 2001; (2001) 181191198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Wittstein, D. A. Kass, P. H. Pak, W. L. Maughan, B. Fetics, and J. M. Hare Cardiac nitric oxide production due to angiotensin-converting enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilated cardiomyopathy J. Am. Coll. Cardiol., August 1, 2001; 38(2): 429 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mak, E. R. Azevedo, P. P. Liu, and G. E. Newton Effect of Hyperoxia on Left Ventricular Function and Filling Pressures in Patients With and Without Congestive Heart Failure Chest, August 1, 2001; 120(2): 467 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. K.M. Decking, J. P. Williams, R. Dahmann, T. Stumpe, M. Kelm, and J. Schrader The nitric oxide-induced reduction in cardiac energy supply is not due to inhibition of creatine kinase Cardiovasc Res, August 1, 2001; 51(2): 313 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Y. T. Hart, E. L. Hahn, D. M. Meyer, J. C. Burnett Jr., and M. M. Redfield Differential effects of natriuretic peptides and NO on LV function in heart failure and normal dogs Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H146 - H154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M Bryant, C. E Sears, L. Rigg, D. A Terrar, and B. Casadei Nitric oxide does not modulate the hyperpolarization-activated current, If, in ventricular myocytes from spontaneously hypertensive rats Cardiovasc Res, July 1, 2001; 51(1): 51 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S Hayward, W. V Kalnins, and R. P Kelly Gender-related differences in left ventricular chamber function Cardiovasc Res, February 1, 2001; 49(2): 340 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Zieman, G. Gerstenblith, E. G. Lakatta, G. O. Rosas, K. Vandegaer, K. M. Ricker, and J. M. Hare Upregulation of the Nitric Oxide-cGMP Pathway in Aged Myocardium : Physiological Response to l-Arginine Circ. Res., January 19, 2001; 88(1): 97 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M T Kearney, J M Cotton, P J Richardson, and A M Shah Viral myocarditis and dilated cardiomyopathy: mechanisms, manifestations, and management Postgrad. Med. J., January 1, 2001; 77(903): 4 - 10. [Abstract] [Full Text]
|
|
|
|
|
|
C. S. Hayward, W. V. Kalnins, and R. P. Kelly Acute effects of 17beta -estradiol on ventricular and vascular hemodynamics in postmenopausal women Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2277 - H2284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Paolocci, U. E. G. Ekelund, T. Isoda, M. Ozaki, K. Vandegaer, D. Georgakopoulos, R. W. Harrison, D. A. Kass, and J. M. Hare cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1982 - H1988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Y. Jiang, T. Costachescu, M. Derouin, and G. Blaise Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators Can J Anesth, June 1, 2000; 47(6): 552 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Grossman Defining Diastolic Dysfunction Circulation, May 2, 2000; 101(17): 2020 - 2021. [Full Text] [PDF]
|
|
|
|
|
|
T. Shinke, H. Takaoka, M. Takeuchi, K. Hata, H. Kawai, H. Okubo, Y. Kijima, T. Murata, and M. Yokoyama Nitric Oxide Spares Myocardial Oxygen Consumption Through Attenuation of Contractile Response to {beta}-Adrenergic Stimulation in Patients With Idiopathic Dilated Cardiomyopathy Circulation, April 25, 2000; 101(16): 1925 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fraser, S. T. Davidge, and A. S. Clanachan Activation of Ca2+-independent nitric oxide synthase by 17{beta}-estradiol in post-ischemic rat heart Cardiovasc Res, April 1, 2000; 46(1): 111 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gyurko, P. Kuhlencordt, M. C. Fishman, and P. L. Huang Modulation of mouse cardiac function in vivo by eNOS and ANP Am J Physiol Heart Circ Physiol, March 1, 2000; 278(3): H971 - H981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. MacCarthy, R. Grocott-Mason, B. D. Prendergast, and A. M. Shah Contrasting Inotropic Effects of Endogenous Endothelin in the Normal and Failing Human Heart : Studies With an Intracoronary ETA Receptor Antagonist Circulation, January 18, 2000; 101(2): 142 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. I. Joffe, K. E. Travers, C. L. Perreault-Micale, T. Hampton, S. E. Katz, J. P. Morgan, and P. S. Douglas Abnormal cardiac function in the streptozotocin-induced, non-insulin-dependent diabetic rat: Noninvasive assessment with Doppler echocardiography and contribution of the nitric oxide pathway J. Am. Coll. Cardiol., December 1, 1999; 34(7): 2111 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O.-E. Brodde and M. C. Michel Adrenergic and Muscarinic Receptors in the Human Heart Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Murray, S. D. Prabhu, and G. L. Freeman Hemodynamic effects of nitric oxide synthase inhibition at steady state and following tumor necrosis factor-{alpha}-induced myodepression Cardiovasc Res, December 1, 1999; 44(3): 527 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J Paulus and A. M Shah NO and cardiac diastolic function Cardiovasc Res, August 15, 1999; 43(3): 595 - 606. [Full Text] [PDF]
|
|
|
|
|
|
C. Heymes, M. Vanderheyden, J. G. F. Bronzwaer, A. M. Shah, and W. J. Paulus Endomyocardial Nitric Oxide Synthase and Left Ventricular Preload Reserve in Dilated Cardiomyopathy Circulation, June 15, 1999; 99(23): 3009 - 3016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Matter, L. Mandinov, P. A. Kaufmann, G. Vassalli, Z. Jiang, and O. M. Hess Effect of NO Donors on LV Diastolic Function in Patients With Severe Pressure-Overload Hypertrophy Circulation, May 11, 1999; 99(18): 2396 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kojda and K. Kottenberg Regulation of basal myocardial function by NO Cardiovasc Res, March 1, 1999; 41(3): 514 - 523. [Full Text] [PDF]
|
|
|
|
|
|
D. P. Slovut, J. C. Wenstrom, R. B. Moeckel, C. T. Salerno, S. J. Park, and J. W. Osborn Beat-to-beat modulation of heart rate is coupled to coronary perfusion pressure in the isolated heart J Appl Physiol, February 1, 1999; 86(2): 694 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Kal, I. Vergroesen, and H. B. van Wezel The Effect of Nitroglycerin on Pacing-Induced Changes in Myocardial Oxygen Consumption and Metabolic Coronary Vasodilation in Patients with Coronary Artery Disease Anesth. Analg., February 1, 1999; 88(2): 271 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Recchia, P. I. McConnell, R. D. Bernstein, T. R. Vogel, X. Xu, and T. H. Hintze Reduced Nitric Oxide Production and Altered Myocardial Metabolism During the Decompensation of Pacing-Induced Heart Failure in the Conscious Dog Circ. Res., November 16, 1998; 83(10): 969 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Drexler, S. Kastner, A. Strobel, R. Studer, O. E. Brodde, and G. Hasenfuss Expression, activity and functional significance of inducible nitric oxide synthase in the failing human heart J. Am. Coll. Cardiol., October 1, 1998; 32(4): 955 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Panas, F. H. Khadour, C. Szabo, and R. Schulz Proinflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H1016 - H1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Bayraktutan, Z.-K. Yang, and A. M Shah Selective dysregulation of nitric oxide synthase type 3 in cardiac myocytes but not coronary microvascular endothelial cells of spontaneously hypertensive rat Cardiovasc Res, June 1, 1998; 38(3): 719 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Ali, M. Gandhi, B. A. Finegan, A. Koshal, and A. S. Clanachan Cardioprotection by Activation of NO/cGMP Pathway After Cardioplegic Arrest and 8-Hour Storage Ann. Thorac. Surg., May 1, 1998; 65(5): 1303 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|