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(Circulation. 1954;9:416.)
© 1954 American Heart Association, Inc.

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Stages of Salt Exchange in Essential Hypertension

D. M. GREEN M.D.¹; A. D. JOHNSON M.D.¹; W. C. BRIDGES M.D.¹; J. H. LEHMANN M.D.¹

¹ From the University of Southern California School of Medicine, Los Angeles, and the University of Washington School of Medicine, Seattle, Wash.

The relation of sodium to hypertension remains one of the most fascinating problems in medicine. The results accumulated over a five-year period of study of this relationship are presented in the paper which follows. In these investigations the appetite for salt and the output of sodium under a variety of loading conditions have been correlated with cardiac and renal function and compared with the patterns found in experimental corticoid and renal hypertensions.