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(Circulation. 1954;9:700.)
© 1954 American Heart Association, Inc.

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Studies on the Renal Circulation and Renal Function in Mitral Valvular Disease

II. Effect of Apresoline

LARS WERKÖ M.D.¹; EDVARDAS VARNAUSKAS M.D.¹; JAN EK M.D.¹; HÄRJE BUCHT M.D.¹; BENGT THOMASSON M.D.¹; JONAS BERGSTRÖM M.K.¹; HARALD ELIASCH M.D.¹

¹ From the IVth Medical Service and Central Laboratory, St. Erik's Hospital, Stockholm, Sweden.

In a study of the nature of the renal changes in patients with mitral stenosis, lowered renal function and reduced renal circulation the effect of Apresoline, given during heart catheterization to 12 patients with mitral stenosis of varying severity, was studied. The drug was found to increase renal blood flow (and decrease arterial blood pressure), showing that the renal changes in mitral stenosis are reversible. The two effects of Apresoline were shown to be independent of each other.