Circulation, Vol 90, 121-126, Copyright © 1994 by American Heart Association
HV Huikuri, MJ Niemela, S Ojala, A Rantala, MJ Ikaheimo and KE Airaksinen
BACKGROUND: Altered neural regulation of the cardiovascular system may be
an important factor for various manifestations of ischemic heart disease.
This research was designed to compare the circadian rhythm of cardiac
neural regulation and autonomic responses to arousal and upright posture
between patients with uncomplicated coronary artery disease (CAD) and
age-matched subjects with no evidence of heart disease. METHODS AND
RESULTS: Twenty-four-hour heart rate variability (HRV) in the frequency
domain was analyzed in 20 male patients (mean age, 52 +/- 7 years) with
angiographic evidence of CAD without prior myocardial infarction and in 20
healthy men (mean age, 51 +/- 8 years) with no clinical, echocardiographic,
or exercise ECG evidence of heart disease. None of the 24-hour average
frequency-domain components of HRV differed significantly between the two
groups. Healthy subjects had a significant circadian rhythm of normalized
units of high-frequency (HF) power of HRV with higher values during sleep.
Normalized units of low- frequency (LF) power and the LF/HF ratio also
showed a significant circadian rhythm in healthy subjects, with higher
values during the daytime. No significant circadian rhythms in any of the
normalized spectral components of HRV were observed in patients with CAD,
and the night-day difference in LF/HF ratio was smaller in the patients
with CAD than in the healthy subjects (0.5 +/- 1.4 versus 1.8 +/- 0.7, P
< .001). Awakening when in the supine position resulted in a significant
increase in the LF/HF ratio (P < .01) in the healthy subjects, but no
significant changes in HRV were observed after awakening in patients with
CAD. Assumption of upright position resulted in a comparable decrease in
the components of HRV between the groups. CONCLUSIONS: The circadian rhythm
of cardiac neural regulation is altered in patients with uncomplicated CAD.
Reduced autonomic responses to sleep-wake rhythm suggest that the
modulation of cardiac autonomic function by stimuli from the central
nervous system is impaired in CAD.
ARTICLES
Circadian rhythms of frequency domain measures of heart rate variability in healthy subjects and patients with coronary artery disease. Effects of arousal and upright posture
Department of Medicine, University of Oulu, Finland.
This article has been cited by other articles:
 |
|
 |
|
  U. Wilbert-Lampen, D. Leistner, S. Greven, T. Pohl, S. Sper, C. Volker, D. Guthlin, A. Plasse, A. Knez, H. Kuchenhoff, et al. Cardiovascular Events during World Cup Soccer N. Engl. J. Med., January 31, 2008; 358(5): 475 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bein, R. Hanss, J. Scholz, P. H. Tonner, H. Hemingway, M. Shipley, E. Brunner, A. Britton, M. Marmot, and M. Malik Letter Regarding Article by Hemingway et al, "Does Autonomic Function Link Social Position to Coronary Risk?: The Whitehall II Study" * Response Circulation, December 20, 2005; 112(25): e368 - e369. [Full Text] [PDF]
|
|
|
|
 |
|
 E Ronkainen, H Ansakorpi, H V Huikuri, V V Myllyla, J I T Isojarvi, and J T Korpelainen Suppressed circadian heart rate dynamics in temporal lobe epilepsy J. Neurol. Neurosurg. Psychiatry, October 1, 2005; 76(10): 1382 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P Sloan, M.-H. Huang, S. Sidney, K. Liu, O D. Williams, and T. Seeman Socioeconomic status and health: is parasympathetic nervous system activity an intervening mechanism? Int. J. Epidemiol., April 1, 2005; 34(2): 309 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Gami, D. E. Howard, E. J. Olson, and V. K. Somers Day-Night Pattern of Sudden Death in Obstructive Sleep Apnea N. Engl. J. Med., March 24, 2005; 352(12): 1206 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vikman, K. Lindgren, T. H. Makikallio, S. Yli-Mayry, K.E. J. Airaksinen, and H. V. Huikuri Heart rate turbulence after atrial premature beats before spontaneous onset of atrial fibrillation J. Am. Coll. Cardiol., January 18, 2005; 45(2): 278 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Burg, R. Lampert, T. Joska, W. Batsford, and D. Jain Psychological Traits and Emotion-Triggering of ICD Shock-Terminated Arrhythmias Psychosom Med, November 1, 2004; 66(6): 898 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yasuma and J.-i. Hayano Respiratory Sinus Arrhythmia: Why Does the Heartbeat Synchronize With Respiratory Rhythm? Chest, February 1, 2004; 125(2): 683 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lampert, T. Joska, M. M. Burg, W. P. Batsford, C. A. McPherson, and D. Jain Emotional and Physical Precipitants of Ventricular Arrhythmia Circulation, October 1, 2002; 106(14): 1800 - 1805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Ansakorpi, J T Korpelainen, H V Huikuri, U Tolonen, V V Myllyla, and J I T Isojarvi Heart rate dynamics in refractory and well controlled temporal lobe epilepsy J. Neurol. Neurosurg. Psychiatry, January 1, 2002; 72(1): 26 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Miyamoto, M. Fujita, H. Sekiguchi, Y. Okano, N. Nagaya, K. Ueda, S.-i. Tamaki, R. Nohara, S. Eiho, and S. Sasayama Effects of posture on cardiac autonomic nervous activity in patients with congestive heart failure J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1788 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bergholm, J. Westerbacka, S. Vehkavaara, A. Seppälä-Lindroos, T. Goto, and H. Yki-Järvinen Insulin Sensitivity Regulates Autonomic Control of Heart Rate Variation Independent of Body Weight in Normal Subjects J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1403 - 1409. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. M Massin, K. Maeyns, N. Withofs, F. Ravet, P. Gerard;, and M J R HEALY Circadian rhythm of heart rate and heart rate variability Arch. Dis. Child., August 1, 2000; 83(2): 179 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lampert, D. Jain, M. M. Burg, W. P. Batsford, and C. A. McPherson Destabilizing Effects of Mental Stress on Ventricular Arrhythmias in Patients With Implantable Cardioverter-Defibrillators Circulation, January 18, 2000; 101(2): 158 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J M Serrador, H C Finlayson, and R L Hughson Physical activity is a major contributor to the ultra low frequency components of heart rate variability Heart, December 1, 1999; 82(6): 9e - 9. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Stahle, R. Nordlander, and L. Bergfeldt Aerobic group training improves exercise capacity and heart rate variability in elderly patients with a recent coronary event. A randomized controlled study Eur. Heart J., November 2, 1999; 20(22): 1638 - 1646. [Abstract] [PDF]
|
|
|
|
|
|
H. V. Huikuri, A.-M. Poutiainen, T. H. Makikallio, M. J. Koistinen, K. E. J. Airaksinen, R. D. Mitrani, R. J. Myerburg, and A. Castellanos Dynamic Behavior and Autonomic Regulation of Ectopic Atrial Pacemakers Circulation, September 28, 1999; 100(13): 1416 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. V. Huikuri, V. Jokinen, M. Syvanne, M. S. Nieminen, K. E. J. Airaksinen, M. J. Ikaheimo, J. M. Koistinen, H. Kauma, A. Y. Kesaniemi, S. Majahalme, et al. Heart Rate Variability and Progression of Coronary Atherosclerosis Arterioscler. Thromb. Vasc. Biol., August 1, 1999; 19(8): 1979 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Pikkujamsa, T. H. Makikallio, L. B. Sourander, I. J. Raiha, P. Puukka, J. Skytta, C.-K. Peng, A. L. Goldberger, and H. V. Huikuri Cardiac Interbeat Interval Dynamics From Childhood to Senescence : Comparison of Conventional and New Measures Based on Fractals and Chaos Theory Circulation, July 27, 1999; 100(4): 393 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Korpelainen, K. A. Sotaniemi, A. Makikallio, H. V. Huikuri, and V. V. Myllyla Dynamic Behavior of Heart Rate in Ischemic Stroke Stroke, May 1, 1999; 30(5): 1008 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. Huikuri, T. H. Makikallio, K. E. J. Airaksinen, T. Seppanen, P. Puukka, I. J. Raiha, and L. B. Sourander Power-Law Relationship of Heart Rate Variability as a Predictor of Mortality in the Elderly Circulation, May 26, 1998; 97(20): 2031 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Nakagawa, T Iwao, S Ishida, H Yonemochi, T Fujino, T Saikawa, and M Ito Circadian rhythm of the signal averaged electrocardiogram and its relation to heart rate variability in healthy subjects Heart, May 1, 1998; 79(5): 493 - 496. [Abstract] [Full Text]
|
|
|
|
|
|
J. T. Korpelainen, K. A. Sotaniemi, H. V. Huikuri, and V. V. Myllyla Circadian Rhythm of Heart Rate Variability Is Reversibly Abolished in Ischemic Stroke Stroke, November 1, 1997; 28(11): 2150 - 2154. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. K Yeragani, E. Sobolewski, J. Kay, V.C Jampala, and G. Igel Effect of age on long-term heart rate variability Cardiovasc Res, July 1, 1997; 35(1): 35 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jault, I. Gandjbakhch, A. Rama, M. Nectoux, V. Bors, E. Vaissier, P. Nataf, A. Pavie, and C. Cabrol Active Native Valve Endocarditis: Determinants of Operative Death and Late Mortality Ann. Thorac. Surg., June 1, 1997; 63(6): 1737 - 1741. [Abstract] [Full Text]
|
|
|
|
|
|
J. Hayano, F. Yasuma, A. Okada, S. Mukai, and T. Fujinami Respiratory Sinus Arrhythmia: A Phenomenon Improving Pulmonary Gas Exchange and Circulatory Efficiency Circulation, August 15, 1996; 94(4): 842 - 847. [Abstract] [Full Text]
|
|
|
|
|
|
H. V. Huikuri, S. M. Pikkujamsa, K.E. J. Airaksinen, M. J. Ikaheimo, A. O. Rantala, H. Kauma, M. Lilja, and Y. A. Kesaniemi Sex-Related Differences in Autonomic Modulation of Heart Rate in Middle-aged Subjects Circulation, July 15, 1996; 94(2): 122 - 125. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. S. Perkiomaki, M. J. Ikaheimo, S. M. Pikkujamsa, A. Rantala, M. Lilja, Y. A. Kesaniemi, and H. V. Huikuri Dispersion of the QT Interval and Autonomic Modulation of Heart Rate in Hypertensive Men With and Without Left Ventricular Hypertrophy Hypertension, July 1, 1996; 28(1): 16 - 21. [Abstract] [Full Text]
|
|
|
|
|
|
E. Vanoli, P. B. Adamson, Ba-Lin, G. D. Pinna, R. Lazzara, and W. C. Orr Heart Rate Variability During Specific Sleep Stages : A Comparison of Healthy Subjects With Patients After Myocardial Infarction Circulation, April 1, 1995; 91(7): 1918 - 1922. [Abstract] [Full Text]
|
|