Circulation, Vol 90, 653-657, Copyright © 1994 by American Heart Association
MA Movsesian, M Karimi, K Green and LR Jones
BACKGROUND: Observations of abnormalities in the diastolic components of
intracellular Ca2+ transients in failing human left ventricular myocardium
have raised the possibility that reductions in the level or function of
sarcoplasmic reticulum proteins involved in Ca2+ transport contribute to
the pathophysiology of dilated cardiomyopathy in humans. Functional assays,
however, have revealed no differences in ATP- dependent Ca2+ transport or
its modulation by phospholamban in sarcoplasmic reticulum-enriched
microsomes prepared from nonfailing and failing human left ventricular
myocardium. The purpose of the present study was to quantify protein levels
of Ca(2+)-transporting ATPase, phospholamban, and calsequestrin directly in
nonfailing and failing human left ventricular myocardium. METHOD AND
RESULTS: Total protein extracts were prepared from nonfailing left
ventricular myocardium from the hearts of unmatched organ donors with
normal left ventricular contractility (n = 6) and from failing left
ventricular myocardium from the excised hearts of transplant recipients
with class IV heart failure resulting from idiopathic dilated
cardiomyopathy (n = 6). Ca(2+)- transporting ATPase, phospholamban, and
calsequestrin contents were determined by quantitative immunoblotting with
monoclonal and affinity- purified polyclonal antibodies. The levels of the
three proteins were identical in nonfailing and failing human left
ventricular myocardium. CONCLUSIONS: These results indicate that protein
levels of Ca(2+)- transporting ATPase, phospholamban, and calsequestrin are
not diminished in failing human left ventricular myocardium and that
downregulation of the Ca(2+)-transporting ATPase and phospholamban is not
part of the molecular pathophysiology of dilated cardiomyopathy in humans.
ARTICLES
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium
Department of Internal Medicine (Cardiology), Salt Lake City Veterans Affairs Medical Center, UT.
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 Y. Sato, D. G. Ferguson, H. Sako, G. W. Dorn II, V. J. Kadambi, A. Yatani, B. D. Hoit, R. A. Walsh, and E. G. Kranias Cardiac-specific Overexpression of Mouse Cardiac Calsequestrin Is Associated with Depressed Cardiovascular Function and Hypertrophy in Transgenic Mice J. Biol. Chem., October 23, 1998; 273(43): 28470 - 28477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
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|
|
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|
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|
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Z. Wang, B. Nolan, W. Kutschke, and J. A. Hill Na+-Ca2+ Exchanger Remodeling in Pressure Overload Cardiac Hypertrophy J. Biol. Chem., May 18, 2001; 276(21): 17706 - 17711. [Abstract] [Full Text] [PDF]
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K. DAVIA, R. J. HAJJAR, C. M. N. TERRACCIANO, N. S. KENT, H. K. RANU, P. O'GARA, A. ROSENZWEIG, and S. E. HARDING Functional alterations in adult rat myocytes after overexpression of phospholamban with use of adenovirus Physiol Genomics, August 31, 1999; 1(2): 41 - 50. [Abstract] [Full Text] [PDF]
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