Circulation, Vol 90, 735-745, Copyright © 1994 by American Heart Association
A Maes, W Flameng, J Nuyts, M Borgers, B Shivalkar, J Ausma, G Bormans, C Schiepers, M De Roo and L Mortelmans
BACKGROUND: In patients with chronic coronary artery disease (CAD) and left
ventricular dysfunction, flow/metabolic studies of the myocardium with
positron emission tomography (PET) are able to distinguish viable but
dysfunctional myocardium from irreversible ischemic injury and scar tissue.
In this study, PET findings of blood flow and metabolism in chronically
hypoperfused myocardium were correlated with histology. METHODS AND
RESULTS: We studied 33 patients suffering from CAD. In each patient,
myocardial blood flow and metabolism were measured with PET 1 or 2 days
before revascularization. During surgery, transmural biopsies were taken
from the left ventricular anterior wall and planimetrically scored for the
degree of myolysis (sarcomere loss). The amount of connective tissue was
calculated using morphometric techniques. Contrast ventriculography
demonstrated abnormal wall motion in 23 patients. Fourteen patients with a
mismatch pattern (decreased flow with preserved metabolism) in the biopsy
region after quantitative analysis of the PET data showed 11 +/- 6 vol%
fibrosis and 25 +/- 13% cells with sarcomere loss. The space formerly
occupied by sarcomeres was mainly replaced by glycogen and mitochondria. A
significant wall motion improvement was noted 3 months after surgery. Nine
patients showed a match pattern (concordant flow/metabolism defects). The
biopsies revealed 35 +/- 25% fibrosis and 24 +/- 15% glycogen-storing
cells. The biopsies of the 10 patients with normal anterior wall motion
showed 8 +/- 4% fibrosis and 12 +/- 8% glycogen-accumulating cells.
CONCLUSIONS: It can be concluded that areas with impaired wall motion and a
PET match pattern show extensive fibrosis. Regions with reduced flow and
preserved FDG metabolism, however, contain predominantly viable cells. In
these regions, significant recovery of wall motion is found after
revascularization. Regions with normal wall motion contain predominantly
viable cells. Cells with reduced contractile material and increased
glycogen content are mainly found in areas with wall motion impairment but
are also present in areas with normal wall motion and a severe stenosis of
the coronary vessel.
ARTICLES
Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings
Department of Nuclear Medicine, Katholieke Universiteit Leuven, Belgium.
This article has been cited by other articles:
 |
|
 |
|
  A. Angelini, G. Maiolino, G. La Canna, C. Ceconi, F. Calabrese, E. Pettenazzo, M. Valente, O. Alfieri, G. Thiene, and R. Ferrari Relevance of apoptosis in influencing recovery of hibernating myocardium Eur J Heart Fail, April 1, 2007; 9(4): 377 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bito, J. van der Velden, P. Claus, C. Dommke, A. Van Lommel, L. Mortelmans, E. Verbeken, B. Bijnens, G. Stienen, and K. R. Sipido Reduced Force Generating Capacity in Myocytes From Chronically Ischemic, Hibernating Myocardium Circ. Res., February 2, 2007; 100(2): 229 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Mariscalco, K. G. Engstrom, S. Ferrarese, G. Cozzi, V. D. Bruno, F. Sessa, and A. Sala Relationship between atrial histopathology and atrial fibrillation after coronary bypass surgery J. Thorac. Cardiovasc. Surg., June 1, 2006; 131(6): 1364 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Heusch, R. Schulz, and S. H. Rahimtoola Myocardial hibernation: a delicate balance Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H984 - H999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ad, A. Schneider, I. Khaliulin, J. B. Borman, and H. Schwalb Impaired mitochondrial response to simulated ischemic injury as a predictor of the development of atrial fibrillation after cardiac surgery: In vitro study in human myocardium J. Thorac. Cardiovasc. Surg., January 1, 2005; 129(1): 41 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J J Bax, E E van der Wall, and M Harbinson Radionuclide techniques for the assessment of myocardial viability and hibernation Heart, August 1, 2004; 90(suppl_5): v26 - v33. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Milei, C. G. Fraga, D. R. Grana, R. Ferreira, and G. Ambrosio Ultrastructural evidence of increased tolerance of hibernating myocardium to cardioplegic ischemia-reperfusion injury J. Am. Coll. Cardiol., June 16, 2004; 43(12): 2329 - 2336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Canty Jr, G. Suzuki, M. D. Banas, F. Verheyen, M. Borgers, and J. A. Fallavollita Hibernating Myocardium: Chronically Adapted to Ischemia but Vulnerable to Sudden Death Circ. Res., April 30, 2004; 94(8): 1142 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bito, F. R. Heinzel, F. Weidemann, C. Dommke, J. van der Velden, E. Verbeken, P. Claus, B. Bijnens, I. De Scheerder, G. J.M. Stienen, et al. Cellular Mechanisms of Contractile Dysfunction in Hibernating Myocardium Circ. Res., April 2, 2004; 94(6): 794 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A F L Schinkel, E C Vourvouri, J J Bax, F Boomsma, M Bountioukos, V Rizzello, E Biagini, E Agricola, A Elhendy, J R T C Roelandt, et al. Relation between left ventricular contractile reserve during low dose dobutamine echocardiography and plasma concentrations of natriuretic peptides Heart, March 1, 2004; 90(3): 293 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hasegawa, H. Kusuoka, K. Maruyama, T. Nishimura, M. Hori, and J. Hatazawa Myocardial positron emission computed tomographic images obtained with fluorine-18 fluoro-2-deoxyglucose predict the response of idiopathic dilated cardiomyopathy patients to beta-blockers J. Am. Coll. Cardiol., January 21, 2004; 43(2): 224 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R H J A Slart, P L Jager, L Poot, D A Piers, J-W Cohen Tervaert, and C A Stegeman Clinical value of gallium-67 scintigraphy in assessment of disease activity in Wegener's granulomatosis Ann Rheum Dis, July 1, 2003; 62(7): 659 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Kuhl, A. M. Beek, A. P. van der Weerdt, M. B. M. Hofman, C. A. Visser, A. A. Lammertsma, N. Heussen, F. C. Visser, and A. C. van Rossum Myocardial viability inchronic ischemic heart disease: Comparison of contrast-enhanced magnetic resonance imaging with 18F-fluorodeoxyglucose positron emission tomography J. Am. Coll. Cardiol., April 16, 2003; 41(8): 1341 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Menasche, A. A. Hagege, J.-T. Vilquin, M. Desnos, E. Abergel, B. Pouzet, A. Bel, S. Sarateanu, M. Scorsin, K. Schwartz, et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction J. Am. Coll. Cardiol., April 2, 2003; 41(7): 1078 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. C. Visser Prediction of Surgical Treatment Effect by Preoperative Imaging:Present and Future Perspectives Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2003; 7(1): 31 - 36. [PDF]
|
|
|
|
|
|
M. Hernandez-Pampaloni, V. Allada, M. C. Fishbein, and H. R. Schelbert Myocardial perfusion and viability by positron emission tomography in infants and children with coronary abnormalities: correlation with echocardiography,coronary angiography, and histopathology J. Am. Coll. Cardiol., February 19, 2003; 41(4): 618 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Weidemann, C. Dommke, B. Bijnens, P. Claus, J. D'hooge, P. Mertens, E. Verbeken, A. Maes, F. Van de Werf, I. De Scheerder, et al. Defining the Transmurality of a Chronic Myocardial Infarction by Ultrasonic Strain-Rate Imaging: Implications for Identifying Intramural Viability: An Experimental Study Circulation, February 18, 2003; 107(6): 883 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F.L. Schinkel, J. J. Bax, R. van Domburg, A. Elhendy, R. Valkema, E. C. Vourvouri, F. B. Sozzi, J. R.T.C. Roelandt, and D. Poldermans Dobutamine-Induced Contractile Reserve in Stunned, Hibernating, and Scarred Myocardium in Patients with Ischemic Cardiomyopathy J. Nucl. Med., February 1, 2003; 44(2): 127 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G Camici and O. E Rimoldi Myocardial blood flow in patients with hibernating myocardium Cardiovasc Res, February 1, 2003; 57(2): 302 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hong, S. Aksenov, X. Guan, J. T. Fallon, D. Waters, and C. Chen Remodeling of Small Intramyocardial Coronary Arteries Distal to a Severe Epicardial Coronary Artery Stenosis Arterioscler Thromb Vasc Biol, December 1, 2002; 22(12): 2059 - 2065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Heusch and R. Schulz Hibernating Myocardium: New Answers, Still More Questions! Circ. Res., November 15, 2002; 91(10): 863 - 865. [Full Text] [PDF]
|
|
|
|
|
|
S. A. Thomas, J. A. Fallavollita, G. Suzuki, M. Borgers, and J. M. Canty Jr Dissociation of Regional Adaptations to Ischemia and Global Myolysis in an Accelerated Swine Model of Chronic Hibernating Myocardium Circ. Res., November 15, 2002; 91(10): 970 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shimoni, N. G. Frangogiannis, C. J. Aggeli, K. Shan, M. A. Quinones, R. Espada, G. V. Letsou, G. M. Lawrie, W. L. Winters, M. J. Reardon, et al. Microvascular Structural Correlates of Myocardial Contrast Echocardiography in Patients With Coronary Artery Disease and Left Ventricular Dysfunction: Implications for the Assessment of Myocardial Hibernation Circulation, August 20, 2002; 106(8): 950 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Perin, G. V. Silva, R. Sarmento-Leite, A. L.S. Sousa, M. Howell, R. Muthupillai, B. Lambert, W. K. Vaughn, and S. D. Flamm Assessing Myocardial Viability and Infarct Transmurality With Left Ventricular Electromechanical Mapping in Patients With Stable Coronary Artery Disease: Validation by Delayed-Enhancement Magnetic Resonance Imaging Circulation, August 20, 2002; 106(8): 957 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rucker-Martin, F. Pecker, D. Godreau, and S. N Hatem Dedifferentiation of atrial myocytes during atrial fibrillation: role of fibroblast proliferation in vitro Cardiovasc Res, July 1, 2002; 55(1): 38 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.M. Canty Jr and G. Suzuki Heterogeneity of apoptosis and myolysis in coronary microembolization: a competition between programmed cell death and programmed cell survival Eur. Heart J., June 1, 2002; 23(11): 838 - 840. [Full Text] [PDF]
|
|
|
|
|
|
G.D. Dispersyn, L. Mesotten, B. Meuris, A. Maes, L. Mortelmans, W. Flameng, F. Ramaekers, and M. Borgers Dissociation of cardiomyocyte apoptosis and dedifferentiation in infarct border zones Eur. Heart J., June 1, 2002; 23(11): 849 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mahrholdt, A. Wagner, R.M. Judd, and U. Sechtem Assessment of myocardial viability by cardiovascular magnetic resonance imaging Eur. Heart J., April 2, 2002; 23(8): 602 - 619. [Full Text] [PDF]
|
|
|
|
|
|
M. G. Gunning, R. R. Kaprielian, J. Pepper, D. J. Pennell, M. N. Sheppard, N. J. Severs, K. M. Fox, and S. R. Underwood The histology of viable and hibernating myocardium in relation to imaging characteristics J. Am. Coll. Cardiol., February 6, 2002; 39(3): 428 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Klein, S. G. Nekolla, F. M. Bengel, M. Momose, A. Sammer, F. Haas, B. Schnackenburg, W. Delius, H. Mudra, D. Wolfram, et al. Assessment of Myocardial Viability With Contrast-Enhanced Magnetic Resonance Imaging: Comparison With Positron Emission Tomography Circulation, January 15, 2002; 105(2): 162 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L.J.L. Thijssen, J. Ausma, and M. Borgers Structural remodelling during chronic atrial fibrillation: act of programmed cell survival Cardiovasc Res, October 1, 2001; 52(1): 14 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, F. C. Visser, D. Poldermans, A. Elhendy, J. H. Cornel, E. Boersma, A. van Lingen, P. M. Fioretti, and C. A. Visser Time Course of Functional Recovery of Stunned and Hibernating Segments After Surgical Revascularization Circulation, September 18, 2001; 104 (2009): I-314 - I-318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maes, P. Mertens, and G.R. Sutherland What is the role of cardiac PET in patients with ischaemic heart disease and significant left ventricular dysfunction? Eur. Heart J., September 2, 2001; 22(18): 1629 - 1631. [PDF]
|
|
|
|
 |
|
 N. Ad, E. Snir, B. A. Vidne, and E. Golomb Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation Ann. Thorac. Surg., September 1, 2001; 72(3): 688 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D Dispersyn, E. Geuens, L. Ver Donck, F. C.S Ramaekers, and M. Borgers Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts Cardiovasc Res, August 1, 2001; 51(2): 230 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fallavollita, M. Logue, and J. M. Canty Jr. Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1989 - 1995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Botker, J. F. Lassen, F. Hermansen, H. Wiggers, P. Sogaard, W. Y. Kim, M. Bottcher, L. Thuesen, and A. K. Pedersen Electromechanical Mapping for Detection of Myocardial Viability in Patients With Ischemic Cardiomyopathy Circulation, March 27, 2001; 103(12): 1631 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Maes, F. Van de Werf, L. V. Mesotten, P. B. Flamen, R. S. Kuzo, J. L. Nuyts, and L. Mortelmans Early assessment of regional myocardial blood flow and metabolism in thrombolysis in myocardial infarction flow grade 3 reperfused myocardial infarction using carbon-11-acetate J. Am. Coll. Cardiol., January 1, 2001; 37(1): 30 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wiggers, M. Noreng, P. K. Paulsen, M. Bottcher, H. Egeblad, T. T. Nielsen, and H. E. Botker Energy stores and metabolites in chronic reversibly and irreversibly dysfunctional myocardium in humans J. Am. Coll. Cardiol., January 1, 2001; 37(1): 100 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tawakol, H. A. Skopicki, S. A. Abraham, N. M. Alpert, A. J. Fischman, M. H. Picard, and H. Gewirtz Evidence of reduced resting blood flow in viable myocardial regions with chronic asynergy J. Am. Coll. Cardiol., December 1, 2000; 36(7): 2146 - 2153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Kim, E. Wu, A. Rafael, E.-L. Chen, M. A. Parker, O. Simonetti, F. J. Klocke, R. O. Bonow, and R. M. Judd The Use of Contrast-Enhanced Magnetic Resonance Imaging to Identify Reversible Myocardial Dysfunction N. Engl. J. Med., November 16, 2000; 343(20): 1445 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bukachi, M.Y. Henein, and S.R. Underwood Predicting the outcome of revascularization in ischaemic left ventricular dysfunction Eur. Heart J., August 2, 2000; 21(16): 1290 - 1292. [PDF]
|
|
|
|
|
|
G LaCanna, S.H Rahimtoola, O Visioli, R Giubbini, O Alfieri, M Zognio, E Milan, C Ceconi, M Gargano, R LoRusso, et al. Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium Eur. Heart J., August 2, 2000; 21(16): 1358 - 1367. [Abstract] [PDF]
|
|
|
|
|
|
J. Bogaert, H. Bosmans, A. Maes, P. Suetens, G. Marchal, and F. E. Rademakers Remote myocardial dysfunction after acute anterior myocardial infarction: impact of left ventricular shape on regional function: A magnetic resonance myocardial tagging study J. Am. Coll. Cardiol., May 1, 2000; 35(6): 1525 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Pagano, J N Townend, D V Parums, R S Bonser, and P G Camici Hibernating myocardium: morphological correlates of inotropic stimulation and glucose uptake Heart, April 1, 2000; 83(4): 456 - 461. [Abstract] [Full Text]
|
|
|
|
|
|
C. Depre and H. Taegtmeyer Metabolic aspects of programmed cell survival and cell death in the heart Cardiovasc Res, February 1, 2000; 45(3): 538 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M BERTELLA, F SCALISE, G ERIANO, and R VALENTINI Exercise four hour redistribution thallium-201 SPECT and exercise induced ST segment elevation in detecting viable myocardium in patients with acute MI Heart, January 1, 2000; 83(1): 103a - 103. [Full Text]
|
|
|
|
|
|
H. Lim, J. A. Fallavollita, R. Hard, C. W. Kerr, and J. M. Canty Jr Profound Apoptosis-Mediated Regional Myocyte Loss and Compensatory Hypertrophy in Pigs With Hibernating Myocardium Circulation, December 7, 1999; 100(23): 2380 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Dispersyn, J. Ausma, F. Thone, W. Flameng, J.-L. J. Vanoverschelde, M. A. Allessie, F. C.S. Ramaekers, and M. Borgers Cardiomyocyte remodelling during myocardial hibernation and atrial fibrillation: prelude to apoptosis Cardiovasc Res, September 1, 1999; 43(4): 947 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Canty Jr. and J. A. Fallavollita Resting myocardial flow in hibernating myocardium: validating animal models of human pathophysiology Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H417 - H422. [Full Text] [PDF]
|
|
|
|
|
|
J. E. Saffitz, R. B. Schuessler, and K. A. Yamada Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias Cardiovasc Res, May 1, 1999; 42(2): 309 - 317. [Full Text] [PDF]
|
|
|
|
|
|
H. Schoder, R. Campisi, T. Ohtake, C. K. Hoh, D. H. Moon, J. Czernin, and H. R. Schelbert Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1328 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bogaert, A. Maes, F. Van de Werf, H. Bosmans, M.-C. Herregods, J. Nuyts, W. Desmet, L. Mortelmans, G. Marchal, and F. E. Rademakers Functional Recovery of Subepicardial Myocardial Tissue in Transmural Myocardial Infarction After Successful Reperfusion : An Important Contribution to the Improvement of Regional and Global Left Ventricular Function Circulation, January 12, 1999; 99(1): 36 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Gunning, C. Anagnostopoulos, C. J. Knight, J. Pepper, E. D. Burman, G. Davies, K. M. Fox, D. J. Pennell, P. J. Ell, and S. R. Underwood Comparison of 201Tl, 99mTc-Tetrofosmin, and Dobutamine Magnetic Resonance Imaging for Identifying Hibernating Myocardium Circulation, November 3, 1998; 98(18): 1869 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Parodi, R. De Maria, R. Testa, E. Vitali, L. Ruffini, G. Paleari, E. Gronda, J. Campolo, and A. Pellegrini Super-normal retention in hibernating myocardium: an ex-vivo study using the failing human heart Cardiovasc Res, June 1, 1998; 38(3): 727 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kloner, R. Bolli, E. Marban, L. Reinlib, and E. Braunwald Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning : An NHLBI Workshop Circulation, May 19, 1998; 97(18): 1848 - 1867. [Full Text] [PDF]
|
|
|
|
|
|
R. R. Kaprielian, M. Gunning, E. Dupont, M. N. Sheppard, S. M. Rothery, R. Underwood, D. J. Pennell, K. Fox, J. Pepper, P. A. Poole-Wilson, et al. Downregulation of Immunodetectable Connexin43 and Decreased Gap Junction Size in the Pathogenesis of Chronic Hibernation in the Human Left Ventricle Circulation, February 24, 1998; 97(7): 651 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ausma, M. Wijffels, F. Thone, L. Wouters, M. Allessie, and M. Borgers Structural Changes of Atrial Myocardium due to Sustained Atrial Fibrillation in the Goat Circulation, November 4, 1997; 96(9): 3157 - 3163. [Abstract] [Full Text]
|
|
|
|
|
|
P. G. Camici, W. Wijns, M. Borgers, R. De Silva, R. Ferrari, J. Knuuti, A. A. Lammertsma, A. J. Liedtke, G. Paternostro, and S. F. Vatner Pathophysiological Mechanisms of Chronic Reversible Left Ventricular Dysfunction due to Coronary Artery Disease (Hibernating Myocardium) Circulation, November 4, 1997; 96(9): 3205 - 3214. [Full Text]
|
|
|
|
|
|
M. T. Maki, M. T. Haaparanta, M. S. Luotolahti, P. Nuutila, L.-M. Voipio-Pulkki, J. R. Bergman, O. H. Solin, and J. M. Knuuti Fatty acid uptake is preserved in chronically dysfunctional but viable myocardium Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2473 - H2480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fallavollita, B. J. Perry, and J. M. Canty Jr 18F-2-Deoxyglucose Deposition and Regional Flow in Pigs With Chronically Dysfunctional Myocardium : Evidence for Transmural Variations in Chronic Hibernating Myocardium Circulation, April 1, 1997; 95(7): 1900 - 1909. [Abstract] [Full Text]
|
|
|
|
|
|
S. H. Rahimtoola Hibernating Myocardium Has Reduced Blood Flow at Rest That Increases With Low-Dose Dobutamine Circulation, December 15, 1996; 94(12): 3055 - 3061. [Full Text]
|
|
|
|
|
|
K. T. Sun, J. Czernin, J. Krivokapich, Y.-K. Lau, M. Bottcher, G. Maurer, M. E. Phelps, and H. R. Schelbert Effects of Dobutamine Stimulation on Myocardial Blood Flow, Glucose Metabolism, and Wall Motion in Normal and Dysfunctional Myocardium Circulation, December 15, 1996; 94(12): 3146 - 3154. [Abstract] [Full Text]
|
|
|
|
|
|
R. O. Bonow Identification of Viable Myocardium Circulation, December 1, 1996; 94(11): 2674 - 2680. [Full Text]
|
|
|
|
|
|
C. Chen, L. Chen, J. T. Fallon, L. Ma, L. Li, L. Bow, D. Knibbs, R. McKay, L. D. Gillam, and D. D. Waters Functional and Structural Alterations With 24-Hour Myocardial Hibernation and Recovery After Reperfusion: A Pig Model of Myocardial Hibernation Circulation, August 1, 1996; 94(3): 507 - 516. [Abstract] [Full Text]
|
|
|
|
|
|
C. R. deFilippi, D. L. Willett, W. N. Irani, E. J. Eichhorn, C. E. Velasco, and P. A. Grayburn Comparison of Myocardial Contrast Echocardiography and Low-Dose Dobutamine Stress Echocardiography in Predicting Recovery of Left Ventricular Function After Coronary Revascularization in Chronic Ischemic Heart Disease Circulation, November 15, 1995; 92(10): 2863 - 2868. [Abstract] [Full Text]
|
|
|
|
|
|
A. Maes, F. Van de Werf, J. Nuyts, G. Bormans, W. Desmet, and L. Mortelmans Impaired Myocardial Tissue Perfusion Early After Successful Thrombolysis : Impact on Myocardial Flow, Metabolism, and Function at Late Follow-up Circulation, October 15, 1995; 92(8): 2072 - 2078. [Abstract] [Full Text]
|
|
|
|
|
|
K. Clarke and R. L. Veech Metabolic Complexities in Cardiac Imaging Circulation, May 1, 1995; 91(9): 2299 - 2301. [Full Text]
|
|
|
|
|
|
J. A. Fallavollita and J. M. Canty Jr. Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1370 - H1379. [Abstract] [Full Text] [PDF]
|
|