Circulation, Vol 90, 2199-2202, Copyright © 1994 by American Heart Association
K Nakai, C Itoh, Y Miura, K Hotta, T Musha, T Itoh, T Miyakawa, R Iwasaki and K Hiramori
BACKGROUND--The angiotensin I-converting enzyme (ACE) is a key component of
the renin-angiotensin system thought to be important in the pathogenesis of
hypertension and cardiovascular disease. Deletion polymorphism in the ACE
gene may be a risk factor for myocardial infarction in the Caucasian
population. However, this finding has not yet been investigated in the
Japanese population. METHODS AND RESULTS-- A 287-bp insertion/deletion
polymorphism in intron 16 of the ACE gene was examined by polymerase chain
reaction in a cross-sectional study of 100 healthy subjects and 178
patients with coronary artery disease (CAD) (70 angina pectoris, 108
myocardial infarction), whose serum ACE levels were concomitantly measured.
Polymorphism of the ACE gene was characterized by three genotypes: two
deletion alleles (genotype DD), two insertion alleles (genotype II), and
heterozygous alleles (genotype ID). No differences could be detected among
the three genotypes for total cholesterol, HDL cholesterol, and body mass
index. Serum ACE levels were 11.4 +/- 2.7, 14.5 +/- 3.5, and 16.6 +/- 4.6
IU/mL for genotypes II, ID, and DD, respectively. In the study population,
the genotype DD was more closely associated with CAD than the other two
genotypes (ID and II). The frequency of deletion alleles was higher (0.58)
in the CAD group than in healthy control subjects (0.42) (P < .05).
Furthermore, multivessel disease was more strongly associated with deletion
alleles than with insertion alleles (P < .05). CONCLUSIONS--A deletion
polymorphism of the ACE gene is associated with serum ACE activity and
increased risk for CAD in the Japanese.
ARTICLES
Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese
Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
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