Circulation, Vol 90, 2207-2212, Copyright © 1994 by American Heart Association
RA Hegele, JH Brunt and PW Connelly
BACKGROUND--The Hutterite Brethren are a genetic isolate characterized by
high indices of relatedness and a communal agrarian lifestyle. We
hypothesized that variation of the angiotensinogen (AGT) and
angiotensin-converting enzyme (ACE) genes would be associated with
variation in resting blood pressure in this group. We also hypothesized
that the association would depend on the sex of the subjects. METHODS AND
RESULTS--In 741 Hutterites, we measured blood pressure in quadruplicate and
analyzed DNA for genotypes of an insertion/deletion (I/D) polymorphism of
ACE and of two protein polymorphisms of AGT, namely, M235T and T174M. We
tested for association between variation in systolic and diastolic blood
pressures and genotypic class. We observed that genotypes of AGT codon 174
were significantly associated with variation in systolic blood pressure. We
also tested for an interaction between the AGT genotype and sex. We
observed that genotypes of AGT codon 174 were significantly associated with
variation in systolic blood pressure only in men. The AGT codon 174
polymorphism accounted for 3.1% of the total variation in systolic blood
pressure in men. CONCLUSIONS--The association of AGT variation with resting
blood pressure in men is consistent with the existence of important
structural elements within, flanking, or proximal to the AGT gene, whose
functional impact might be related to differences in sex.
ARTICLES
A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate
Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.
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