Circulation, Vol 90, 2367-2374, Copyright © 1994 by American Heart Association
J van der Meer, HL Hillege, WH van Gilst, A Brutel de la Riviere, PH Dunselman, V Fidler, GJ Kootstra, BJ Mulder, M Pfisterer and KI Lie
BACKGROUND--Superior patency rates for internal mammary artery (IMA) grafts
compared with vein coronary bypass grafts have been demonstrated by
retrospective studies. This difference may have been affected by selection
bias of patients and coronary arteries for IMA grafting. METHODS AND
RESULTS--To estimate the difference between IMA and vein grafts, we
analyzed graft patency data of 912 patients who entered a randomized
clinical drug trial. In this trial, 494 patients received both IMA and vein
grafts (group 1) and 418 only vein grafts (group 2). Occlusion rates of IMA
grafts and IMA plus vein grafts in group 1 were compared with those of vein
grafts in group 2. Multivariate analysis was used to compare occlusion
rates of IMA and vein grafts while other variables related to graft patency
were controlled for. In addition, 1- year clinical outcome was assessed by
the incidence of myocardial infarction, thrombosis, major bleeding, and
death. Occlusion rates of distal anastomoses in group 1 versus group 2 were
5.4% (IMA grafts) versus 12.7% (vein grafts) (P < .0001) and 10.4% (IMA
plus vein grafts) versus 12.7% (vein grafts) (P = .14). There was no
difference in adjusted risk of occlusion between IMA grafts and vein grafts
(P = .089). Type and location of distal anastomosis and lumen diameter of
the grafted coronary artery were shown to be predictors of occlusion.
Clinical events occurred in 17.8% (group 1) and 16.0% (group 2) of patients
(P = .53). CONCLUSIONS--The observed difference in 1-year occlusion rates
between IMA and vein grafts can be explained by a maldistribution of graft
characteristics by selection of coronary arteries for IMA grafting rather
than being ascribed to graft material. One-year clinical outcome is not
improved by IMA grafting.
ARTICLES
A comparison of internal mammary artery and saphenous vein grafts after coronary artery bypass surgery. No difference in 1-year occlusion rates and clinical outcome. CABADAS Research Group of the Interuniversity Cardiology Institute of The Netherlands
Department of Cardiology, University Hospital Groningen, The Netherlands.
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