Circulation, Vol 90, 2786-2796, Copyright © 1994 by American Heart Association
GM London, B Pannier, AP Guerin, SJ Marchais, ME Safar and JL Cuche
BACKGROUND: We wished to assess the respective roles of the
antihypertensive and blood pressure (BP)-independent effects of
antihypertensive drugs on arterial hemodynamics and left ventricular
hypertrophy (LVH) in end-stage renal disease (ESRD) patients. METHODS AND
RESULTS: In a double-blind study, 24 ESRD patients with LVH were randomized
to 12 months' administration of either the angiotensin- converting enzyme
(ACE) inhibitor perindopril (n = 14) or the calcium channel blocker
nitrendipine (n = 10). Repeated measurements of the following parameters
were performed: BP (mercury sphygmomanometry), left ventricular mass (LVM,
echocardiography), cardiac output (aortic cross-section and velocity
integral), total peripheral resistance (cardiac output and mean BP), aortic
and large-artery compliance (pulse wave velocity, Doppler flowmeter), and
arterial wave reflections (augmentation index, applanation tonometry).
Radioimmunoassay was used to determine plasma renin activity, aldosterone,
and plasma catecholamine levels. Two-way (time-treatment) ANOVA for
repeated measures was used for statistical analysis. Perindopril and
nitrendipine induced significant and similar decreases in BP, total
peripheral resistance (P < .001), aortic and arterial pulse wave
velocities (P < .001), and arterial wave reflections (P < .01). At
baseline, the two groups had LVH mostly due to increased LV end- diastolic
diameter (LVEDD) (perindopril, 54.3 +/- 1.4 and nitrendipine, 54.3 +/ 2.4
mm) with near-normal mean LV wall thickness (perindopril, 11.4 +/- 0.3 and
nitrendipine, 11.2 +/- 0.4 mm). A decrease in LVM was observed only in
patients receiving perindopril (from 317 +/- 18 to 247 +/- 21 g)
(time-treatment interaction, P = .036). Nitrendipine had no significant
effect on LVM (314 +/- 29 versus 286 +/- 32 g). The decrease in LVM
observed with perindopril was associated with a reduction in LVEDD (49.9
+/- 1.6 versus 54.3 +/- 1.4 mm after 12 months) (time-treatment
interaction, P = .04), while the mean LV wall thickness was unchanged (11.4
+/- 0.3 versus 10.5 +/- 0.5 mm). Cardiac alterations were not correlated
with changes in BP or with alterations in plasma renin activity or
aldosterone or catecholamine levels. CONCLUSIONS: In ESRD patients with
LVH, ACE inhibition decreases LVM independently of its antihypertensive
effect and of associated alterations in arterial hemodynamics. The decrease
in LVM was due primarily to a decrease in LV volume, which may have
resulted in these patients from chronic volume overload.
ARTICLES
Cardiac hypertrophy, aortic compliance, peripheral resistance, and wave reflection in end-stage renal disease. Comparative effects of ACE inhibition and calcium channel blockade
Centre Hospitalier F.H. Manhes, Fleury-Merogis, France.
This article has been cited by other articles:
 |
|
 |
|
  T. G. Papaioannou, K. S. Stamatelopoulos, G. Georgiopoulos, C. Vlachopoulos, S. Georgiou, M. Lykka, I. Lambrinoudaki, C. M. Papamichael, and C. I. Stefanadis Arterial Wave Reflections During the Menstrual Cycle of Healthy Women: A Reproducibility Study Hypertension, November 1, 2009; 54(5): 1021 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-G. Sun, Y.-X. Cao, W.-W. Wang, S.-F. Ma, T. Yao, and Y.-C. Zhu Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes Cardiovasc Res, September 1, 2008; 79(4): 632 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shimizu and K. Kario Review: Role of the augmentation index in hypertension Therapeutic Advances in Cardiovascular Disease, February 1, 2008; 2(1): 25 - 35. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Fox Contribution of perindopril to cardiology: 20 years of success Eur. Heart J. Suppl., September 1, 2007; 9(suppl_E): E10 - E19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Dart, J. D. Cameron, C. D. Gatzka, K. Willson, Y.-L. Liang, K. L. Berry, L. M.H. Wing, C. M. Reid, P. Ryan, L. J. Beilin, et al. Similar Effects of Treatment on Central and Brachial Blood Pressures in Older Hypertensive Subjects in the Second Australian National Blood Pressure Trial Hypertension, June 1, 2007; 49(6): 1242 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Westerhof, I. Guelen, N. Westerhof, J. M. Karemaker, and A. Avolio Quantification of Wave Reflection in the Human Aorta From Pressure Alone: A Proof of Principle Hypertension, October 1, 2006; 48(4): 595 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nehme, N. Mercier, C. Labat, A. Benetos, M. E Safar, C. Delcayre, and P. Lacolley Differences Between Cardiac and Arterial Fibrosis and Stiffness in Aldosterone-Salt Rats: Effect of Eplerenone Journal of Renin-Angiotensin-Aldosterone System, March 1, 2006; 7(1): 31 - 39. [Abstract] [PDF]
|
|
|
|
 |
|
 B A Haluska, K Matthys, R Fathi, E Rozis, S G Carlier, and T H Marwick Influence of arterial compliance on presence and extent of ischaemia during stress echocardiography Heart, January 1, 2006; 92(1): 40 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Ahimastos, A. K. Natoli, A. Lawler, P. A. Blombery, and B. A. Kingwell Ramipril Reduces Large-Artery Stiffness in Peripheral Arterial Disease and Promotes Elastogenic Remodeling in Cell Culture Hypertension, June 1, 2005; 45(6): 1194 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Blankestijn Sympathetic hyperactivity in chronic kidney disease Nephrol. Dial. Transplant., June 1, 2004; 19(6): 1354 - 1357. [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Wu, Y.-P. Lin, W.-C. Yu, W.-S. Lee, T.-L. Hsu, P. Y.-A. Ding, and C.-H. Chen The assessment of fluid status in haemodialysis patients: usefulness of the Doppler echocardiographic parameters Nephrol. Dial. Transplant., March 1, 2004; 19(3): 644 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. London, A. P. Guerin, S. J. Marchais, F. Metivier, B. Pannier, and H. Adda Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality Nephrol. Dial. Transplant., September 1, 2003; 18(9): 1731 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. London Cardiovascular Calcifications in Uremic Patients: Clinical Impact on Cardiovascular Function J. Am. Soc. Nephrol., September 1, 2003; 14(90004): S305 - 309. [Abstract] [Full Text]
|
|
|
|
|
|
B. Pannier, A.P. Guerin, S.J. Marchias, and G.M. London Benefits from angiotensin-converting enzyme inhibition in patients with renal failure: latest results Eur. Heart J. Suppl., July 1, 2003; 5(suppl_E): E18 - E22. [Abstract] [PDF]
|
|
|
|
 |
|
 K.-i. Hirose, H. Tomiyama, R. Okazaki, T. Arai, Y. Koji, G. Zaydun, S. Hori, and A. Yamashina Increased Pulse Wave Velocity Associated with Reduced Calcaneal Quantitative Osteo-sono Index: Possible Relationship Between Atherosclerosis and Osteopenia J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2573 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Meune, I. Mahe, J.-J. Mourad, A. Cohen-Solal, B. Levy, J.-P. Kevorkian, G. Jondeau, A. Habib, M. Lebret, A.-L. Knellwolf, et al. Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect Eur J Heart Fail, June 1, 2003; 5(3): 271 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Oliver and D. J. Webb Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events Arterioscler Thromb Vasc Biol, April 1, 2003; 23(4): 554 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A Sica and T. W. Gehr Review: The pharmacokinetics and pharmacodynamics of angiotensin-receptor blockers in end-stage renal disease Journal of Renin-Angiotensin-Aldosterone System, December 1, 2002; 3(4): 247 - 254. [Abstract] [PDF]
|
|
|
|
|
|
G. M. London, S. J. Marchais, A. P. Guerin, F. Metivier, and H. Adda Arterial structure and function in end-stage renal disease Nephrol. Dial. Transplant., October 1, 2002; 17(10): 1713 - 1724. [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Hunziker, C. Imsand, D. Keller, N. Hess, V.a. Barbosa, F. Nietlispach, N. Liel-Cohen, A. E. Weyman, M. Pfisterer, and P. Buser Bedside quantification of atherosclerosis severity for cardiovascular risk stratification: a prospective cohort study J. Am. Coll. Cardiol., February 20, 2002; 39(4): 702 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. London, B. Pannier, A. P. Guerin, J. Blacher, S. J. Marchais, B. Darne, F. Metivier, H. Adda, and M. E. Safar Alterations of Left Ventricular Hypertrophy in and Survival of Patients Receiving Hemodialysis: Follow-up of an Interventional Study J. Am. Soc. Nephrol., December 1, 2001; 12(12): 2759 - 2767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ayerdi, L. N. Sampson, N. Deshmukh, A. Farid, and S. K. Gupta Carotid Endarterectomy in Patients with Renal Insufficiency: Should Selection Criteria be Different in Patients with Renal Insufficiency? Vascular and Endovascular Surgery, November 1, 2001; 35(6): 429 - 435. [Abstract] [PDF]
|
|
|
|
|
|
I. H. H. T. KLEIN, G. LIGTENBERG, P. L. OEY, H. A. KOOMANS, and P. J. BLANKESTIJN Sympathetic Activity Is Increased in Polycystic Kidney Disease and Is Associated with Hypertension J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2427 - 2433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Asmar, G. M. London, M. E. O'Rourke, and M. E. Safar Improvement in Blood Pressure, Arterial Stiffness and Wave Reflections With a Very-Low-Dose Perindopril/Indapamide Combination in Hypertensive Patient: A Comparison With Atenolol Hypertension, October 1, 2001; 38(4): 922 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Hundley, D. W. Kitzman, T. M. Morgan, C. A. Hamilton, S. N. Darty, K. P. Stewart, D. M. Herrington, K. M. Link, and W. C. Little Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance J. Am. Coll. Cardiol., September 1, 2001; 38(3): 796 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. London, J. Blacher, B. Pannier, A. P. Guerin, S. J. Marchais, and M. E. Safar Arterial Wave Reflections and Survival in End-Stage Renal Failure Hypertension, September 1, 2001; 38(3): 434 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. MIDDLETON, P. S. PARFREY, and R. N. FOLEY Left Ventricular Hypertrophy in the Renal Patient J. Am. Soc. Nephrol., May 1, 2001; 12(5): 1079 - 1084. [Full Text]
|
|
|
|
 |
|
 A. P. Guerin, J. Blacher, B. Pannier, S. J. Marchais, M. E. Safar, and G. M. London Impact of Aortic Stiffness Attenuation on Survival of Patients in End-Stage Renal Failure Circulation, February 20, 2001; 103(7): 987 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Matsumoto, M. Hamada, and K. Hiwada Aortic Distensibility is Closely Related to the Progression of Left Ventricular Hypertrophy in Patients Receiving Hemodialysis Angiology, November 1, 2000; 51(11): 933 - 941. [Abstract] [PDF]
|
|
|
|
|
|
A. P. Guerin, G. M. London, S. J. Marchais, and F. Metivier Arterial stiffening and vascular calcifications in end-stage renal disease Nephrol. Dial. Transplant., July 1, 2000; 15(7): 1014 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Blankestijn, G. Ligtenberg, I. H. H. T. Klein, and H. A. Koomans Sympathetic overactivity in renal failure controlled by ACE inhibition: clinical significance Nephrol. Dial. Transplant., June 1, 2000; 15(6): 755 - 758. [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Safar, J. Blacher, J. J. Mourad, and G. M. London Stiffness of Carotid Artery Wall Material and Blood Pressure in Humans : Application to Antihypertensive Therapy and Stroke Prevention Stroke, March 1, 2000; 31(3): 782 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O.I. Dyadyk, A.E. Bagriy, and N.F. Yarovaya Disorders of left ventricular structure and function in chronic uremia: how often, why and what to do with it? Eur J Heart Fail, December 17, 1999; 1(4): 327 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G.F. Cleland, M. Tendera, J. Adamus, N. Freemantle, C. S. Gray, M. Lye, D. O'Mahony, L. Polonski, J. Taylor, and PEP investigators Perindopril for elderly people with chronic heart failure: the PEP-CHF study Eur J Heart Fail, August 31, 1999; 1(3): 211 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. PARFREY and R. N. FOLEY The Clinical Epidemiology of Cardiac Disease in Chronic Renal Failure J. Am. Soc. Nephrol., July 1, 1999; 10(7): 1606 - 1615. [Full Text]
|
|
|
|
|
|
G. Jondeau, P. Boutouyrie, P. Lacolley, B. Laloux, O. Dubourg, J.-P. Bourdarias, and S. Laurent Central Pulse Pressure Is a Major Determinant of Ascending Aorta Dilation in Marfan Syndrome Circulation, May 25, 1999; 99(20): 2677 - 2681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Topouchian, R. Asmar, F. Sayegh, A. Rudnicki, A. Benetos, A. M. Bacri, and M. E. Safar Changes in Arterial Structure and Function Under Trandolapril-Verapamil Combination in Hypertension Stroke, May 1, 1999; 30(5): 1056 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ligtenberg, P. J. Blankestijn, P. L. Oey, I. H.H. Klein, L.-T. Dijkhorst-Oei, F. Boomsma, G. H. Wieneke, A. C. van Huffelen, and H. A. Koomans Reduction of Sympathetic Hyperactivity by Enalapril in Patients with Chronic Renal Failure N. Engl. J. Med., April 29, 1999; 340(17): 1321 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stefanadis, J. Dernellis, M. Vavuranakis, E. Tsiamis, C. Vlachopoulos, Konstantinos Toutouzas, L. Diamandopoulos, C. Pitsavos, and P. Toutouzas Effects of ventricular pacing-induced tachycardia on aortic mechanics in man Cardiovasc Res, August 1, 1998; 39(2): 506 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Blacher, K. Demuth, A. P. Guerin, M. E. Safar, N. Moatti, and G. M. London Influence of Biochemical Alterations on Arterial Stiffness in Patients With End-stage Renal Disease Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 535 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Mourad, X. Girerd, P. Boutouyrie, S. Laurent, M. Safar, and G. London Increased Stiffness of Radial Artery Wall Material in End-Stage Renal Disease Hypertension, December 1, 1997; 30(6): 1425 - 1430. [Abstract] [Full Text]
|
|
|
|
|
|
K. Amann, B. Wolf, C. Nichols, J. Tornig, U. Schwarz, M. Zeier, G. Mall, and E. Ritz Aortic Changes in Experimental Renal Failure: Hyperplasia or Hypertrophy of Smooth Muscle Cells? Hypertension, March 1, 1997; 29(3): 770 - 775. [Abstract] [Full Text]
|
|
|
|
|
|
R. Tatchum-Talom, N. Niederhoffer, F. Amin, T. Makki, P. Tankosic, and J. Atkinson Aortic Stiffness and Left Ventricular Mass in a Rat Model of Isolated Systolic Hypertension Hypertension, December 1, 1995; 26(6): 963 - 970. [Abstract] [Full Text]
|
|
|
|
|
|
G. M. London, A. P. Guerin, B. Pannier, S. J. Marchais, and M. Stimpel Influence of Sex on Arterial Hemodynamics and Blood Pressure : Role of Body Height Hypertension, September 1, 1995; 26(3): 514 - 519. [Abstract] [Full Text]
|
|
|
|
|
|
M. E. Safar and E. D. Frohlich The Arterial System in Hypertension : A Prospective View Hypertension, July 1, 1995; 26(1): 10 - 14. [Abstract] [Full Text]
|
|