Circulation, Vol 90, 2877-2885, Copyright © 1994 by American Heart Association
JS Wang, CJ Jen, HC Kung, LJ Lin, TR Hsiue and HI Chen
BACKGROUND: Platelets play an important role in the pathogenesis of
cardiovascular diseases. It is also noticed that on one hand, regular
exercise can reduce the risk of cardiovascular diseases, and on the other
hand, vigorous exercise provokes sudden cardiac death. We therefore
hypothesize that various intensities of exercise may affect platelet
function differently. METHODS AND RESULTS: Strenuous and moderate exercise
(about 50% to 55% of peak oxygen consumption, VO2peak) on a bicycle
ergometer in 10 sedentary and 10 physically active healthy young men was
executed on two separate occasions. Blood samples were collected before and
immediately after exercise. A newly designed tapered parallel plate chamber
was used to assess platelet adhesiveness. Platelet aggregation induced by
ADP was evaluated by the percentage of reduction in single platelet count.
beta-Thromboglobulin (beta-TG) and platelet factor 4 (PF4) were measured by
ELISA. In addition, a similar study on 5 patients with stable angina were
also conducted. Our results showed that (1) in the sedentary healthy group,
platelet adhesiveness and aggregation were increased by strenuous exercise
and depressed by moderate exercise; (2) in the active healthy group,
platelet adhesiveness and aggregation were enhanced by severe exercise,
whereas only aggregation was decreased by moderate exercise; (3) in the
patients with stable angina, platelet adhesiveness and aggregation were
enhanced by strenuous exercise and adhesiveness was suppressed by moderate
exercise; (4) the degree of hemoconcentration induced by acute exercise
tended to be related to the severity of exercise in all subjects; and (5)
although severe exercise elevated beta-TG and PF4, there were no
significant changes in beta-TG, PF4, and the ratio of beta-TG to PF4 in
healthy subjects after exercise. CONCLUSIONS: It is concluded that platelet
adhesiveness and aggregability may be sensitized by strenuous exercise in
both healthy subjects and patients with stable angina. In contrast,
platelet function can be suppressed significantly by moderate exercise in
the healthy and tends to be depressed in patients with stable angina. The
former may increase the risk of cardiac arrest and the latter may protect
us from cardiovascular diseases. In addition, the effects of acute exercise
tend to be more pronounced in the sedentary than in the active.
ARTICLES
Different effects of strenuous exercise and moderate exercise on platelet function in men
Department of Physiology, National Cheng-Kung, University Medical College, Tainan, Taiwan, Republic of China.
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