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(Circulation. 1995;91:2721-2724.)
© 1995 American Heart Association, Inc.
Articles |
Angiotensin-Converting Enzyme I/D Polymorphism and Arterial Wall Thickness in a General Population
The Vobarno Study
From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women's Hospital, Boston, Mass (R.K., K.L.).
Correspondence to Dr Maurizio Castellano, UOP Scienze Mediche, University of Brescia, c/o I Medicina, Spedali Civili di Brescia, 25100 Brescia, Italy. E-mail castell@master.cci.unibs.it.
Background It has been reported that the D allele of an insertion/deletion (I/D) polymorphism of the angiotensin I–converting enzyme (ACE) gene is associated with conditions of increased cardiovascular risk, including left ventricular hypertrophy.
Methods and Results Considering that a genetically determined overactivity of the renin-angiotensin system may influence cardiac as well as vascular growth, we investigated possible relations between ACE I/D genotype and carotid artery wall thickness (B-mode ultrasound) in 199 subjects, 50 to 64 years old, sampled from the general population of Vobarno, a small town in northern Italy. ACE DD genotype was associated with significantly higher common carotid artery intima-media thickness (P=.003). The occurrence of carotid atherosclerotic plaques was similar in the different genotypes. There was no association of the ACE I/D genotype with blood pressure values (either casual or 24-hour ambulatory monitored).
Conclusions ACE DD genotype may be considered a risk factor for the development of common carotid intima-media thickening in our study population.
Key Words: angiotensin • enzymes • arteries • population • genes
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