(Circulation. 1995;91:476-485.)
© 1995 American Heart Association, Inc.
Articles |
Does PTCA in Acute Myocardial Infarction Affect Mortality and Reinfarction Rates?
A Quantitative Overview (Meta-Analysis) of the Randomized Clinical Trials
From the Department of Epidemiology, Harvard School of Public Health, Boston, Mass (K.B.M.), and the Division of Cardiology and Program of Preventive Cardiology and Therapeutics, Hamilton General Hospital, McMaster University, Hamilton, Ontario, Canada (S.Y.).
Background Percutaneous transluminal coronary angioplasty (PTCA) is often performed after acute myocardial infarction (AMI) either as an adjuvant to thrombolytic therapy or instead of thrombolysis. The effect of PTCA in AMI on mortality and reinfarction has remained unclear, with the available randomized trials indicating inconsistent results.
Methods and Results A systematic overview (meta-analysis) of the randomized trials was conducted to assess the effect of PTCA in AMI on mortality and reinfarction rates. Data from 7 trials in which primary PTCA was evaluated and 16 trials in which PTCA after thrombolysis was studied were included in this overview, comprising a total of 8496 patients. The trials represented different approaches to the timing of PTCA after AMI. The trials of PTCA after thrombolytic therapy were also categorized according to the different protocols with respect to the routine or elective character of PTCA in the invasive group. A reduction in short-term (6 week) mortality (odds ratio, 0.56; 95% CI, 0.33, 0.94) and in the combined outcome of short-term mortality and nonfatal reinfarction (odds ratio, 0.53; 95% CI, 0.35, 0.80) was observed in the trials comparing primary PTCA with thrombolytic therapy. In contrast, in trials in which an approach of thrombolysis and PTCA was compared with thrombolytic therapy alone, there was no important difference in early mortality, with an apparent reduction in mortality between 6 and 52 weeks. The lower mortality between 6 and 52 weeks among 6-week survivors seemed to be restricted to the subgroup of trials in which PTCA was used as a routine strategy (odds ratio, 0.58; 95% CI, 0.39, 0.87).
Conclusions Although the analyses of the various categories of trials suggest that primary PTCA may be more beneficial than thrombolytic therapy in AMI, these data should be interpreted cautiously unless confirmed by larger studies. In contrast, the addition of various other strategies of PTCA to thrombolytic therapy does not convincingly indicate a clinically different outcome than if a more conservative strategy is followed, in which PTCA is used only if clinically indicated. Some specific strategies, however, such as rescue PTCA in high-risk patients with occluded arteries, may be of benefit.
Key Words: meta-analysis • angioplasty • thrombolysis • myocardial infarction
This article has been cited by other articles:
 |
|
 |
|
  G. Ndrepepa, A. Schomig, and A. Kastrati The Only Better Alternative to Rescue Percutaneous Coronary Intervention Is Primary Percutaneous Coronary Intervention. J. Am. Coll. Cardiol., July 7, 2009; 54(2): 127 - 129. [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Lindholm, S. Boesgaard, J. J. Thune, H. Kelbaek, H. R. Andersen, L. Kober, and DANAMI-2 investigators Percutaneous coronary intervention for acute MI does not prevent in-hospital development of cardiogenic shock compared to fibrinolysis Eur J Heart Fail, July 1, 2008; 10(7): 668 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Brown, T. M. Sundt III, and B. J. Gersh Indications for Revascularization Card. Surg. Adult, January 1, 2008; 3(2008): 551 - 572. [Full Text]
|
|
|
|
 |
|
 P. Sorajja, B. J. Gersh, D. A. Cox, M. G. McLaughlin, P. Zimetbaum, C. Costantini, T. Stuckey, J. E. Tcheng, R. Mehran, A. J. Lansky, et al. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction Eur. Heart J., July 2, 2007; 28(14): 1709 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Stenestrand, J. Lindback, L. Wallentin, and for the RIKS-HIA Registry Long-term outcome of primary percutaneous coronary intervention vs prehospital and in-hospital thrombolysis for patients with ST-elevation myocardial infarction. JAMA, October 11, 2006; 296(14): 1749 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Collet, G. Montalescot, M. Le May, M. Borentain, and A. Gershlick Percutaneous Coronary Intervention After Fibrinolysis: A Multiple Meta-Analyses Approach According to the Type of Strategy J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1326 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Borden and D. P. Faxon Facilitated Percutaneous Coronary Intervention J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1120 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kereiakes and E. M. Antman Clinical Guidelines and Practice: In Search of the Truth J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1129 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Part 8: Stabilization of the Patient With Acute Coronary Syndromes Circulation, December 13, 2005; 112(24_suppl): IV-89 - IV-110. [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Cantor, F. Brunet, C. P. Ziegler, A. Kiss, and L. J. Morrison Immediate angioplasty after thrombolysis: a systematic review Can. Med. Assoc. J., December 6, 2005; 173(12): 1473 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Part 5: Acute Coronary Syndromes Circulation, November 29, 2005; 112(22_suppl): III-55 - III-72. [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Bilge, Y. Nisanci, E. Yilmaz, B. Ozben, A. Oncul, F. Mercanoglu, and M. Meric Effects of Percutaneous Coronary Thrombectomywith the X-Sizer Catheter on Epicardial Flow and Microvascular Function in Acute Coronary Syndromes Clinical and Applied Thrombosis/Hemostasis, October 1, 2005; 11(4): 461 - 466. [Abstract] [PDF]
|
|
|
|
|
|
W. J. Cantor and L. J. Morrison Guidelines for STEMI Can. Med. Assoc. J., May 24, 2005; 172(11): 1425 - 1425. [Full Text] [PDF]
|
|
|
|
|
|
A. J.J. McClelland, C. G. Owens, S. J. Walsh, D. McCarty, T. Mathew, M. Stevenson, H. Gracey, M. M. Khan, and A.A. J. Adgey Percutaneous coronary intervention and 1 year survival in patients treated with fibrinolytic therapy for acute ST-elevation myocardial infarction Eur. Heart J., March 2, 2005; 26(6): 544 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Bhatia, G J Clesham, and D R Turner Clinical implications of ST-segment non-resolution after thrombolysis for myocardial infarction J R Soc Med, December 1, 2004; 97(12): 566 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ilkay, I. Karaca, M. Akbulut, A E. Kilicoglu, M. Yavuzkir, and N. Arslan Excimer Laser Coronary Angioplasty in Acute Myocardial Infarction Asian Cardiovasc Thorac Ann, December 1, 2004; 12(4): 291 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takada, M. Hashimoto, J. Kasahara, K. Aihara, and K. Fukunaga Cytoprotective Effect of Sodium Orthovanadate on Ischemia/Reperfusion-Induced Injury in the Rat Heart Involves Akt Activation and Inhibition of Fodrin Breakdown and Apoptosis J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1249 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Scheller, B. Hennen, B. Hammer, J. Walle, C. Hofer, V. Hilpert, H. Winter, G. Nickenig, M. Bohm, and SIAM III Study Group Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction J. Am. Coll. Cardiol., August 20, 2003; 42(4): 634 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Natarajan and S. Yusuf Primary angioplasty for ST-segment elevation myocardial infarction: Ready for prime time? Can. Med. Assoc. J., July 8, 2003; 169(1): 32 - 35. [Full Text] [PDF]
|
|
|
|
|
|
T. M. Sundt III, B. J. Gersh, and H. C. Smith Indications for Coronary Revascularization Card. Surg. Adult, January 1, 2003; 2(2003): 541 - 559. [Full Text]
|
|
|
|
|
|
J. T. Willerson Myocardial Revascularization with Cardiologic Interventional Devices Card. Surg. Adult, January 1, 2003; 2(2003): 561 - 580. [Full Text]
|
|
|
|
 |
|
 P Tyden, O Hansen, G Engstrom, B Hedblad, and L Janzon Myocardial infarction in an urban population: worse long term prognosis for patients from less affluent residential areas J Epidemiol Community Health, October 1, 2002; 56(10): 785 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-i. Kotani, S. Nanto, G. S. Mintz, M. Kitakaze, T. Ohara, T. Morozumi, S. Nagata, and M. Hori Plaque Gruel of Atheromatous Coronary Lesion May Contribute to the No-Reflow Phenomenon in Patients With Acute Coronary Syndrome Circulation, September 24, 2002; 106(13): 1672 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Brouwer, P. J.P.C. van den Bergh, W. R.M. Aengevaeren, G. Veen, H. E. Luijten, D. P. Hertzberger, A. J. van Boven, R. P.J.W. Vromans, G. J.H. Uijen, and F. W.A. Verheugt Aspirin Plus Coumarin Versus Aspirin Alone in the Prevention of Reocclusion After Fibrinolysis for Acute Myocardial Infarction: Results of the Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis (APRICOT)-2 Trial Circulation, August 6, 2002; 106(6): 659 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Cohen, D. G. Murphy, and J. Williams Review of the Current ACS Practice Guideline to Develop an Ischemic Chest Pain Protocol Journal of Pharmacy Practice, June 1, 2002; 15(3): 250 - 266. [Abstract] [PDF]
|
|
|
|
|
|
Y. Elad, W. J. French, D. M. Shavelle, L. S. Parsons, M. J. Sada, N. R. Every, and Participants in the National Registry of Myocardia Primary angioplasty and selection bias inpatients presenting late (>12 h) after onset of chest pain and ST elevation myocardial infarction J. Am. Coll. Cardiol., March 6, 2002; 39(5): 826 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hamada, T. Nishiue, S. Nakamura, T. Sugiura, H. Kamihata, H. Miyoshi, Y. Imuro, and T. Iwasaka TIMI frame count immediately after primary coronary angioplasty as a predictor of functional recovery in patients with TIMI 3 reperfused acute myocardial infarction J. Am. Coll. Cardiol., September 1, 2001; 38(3): 666 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A K GITT and J SENGES The patient with acute myocardial infarction who does not receive reperfusion treatment Heart, September 1, 2001; 86(3): 243 - 245. [Full Text] [PDF]
|
|
|
|
|
|
S.G. Priori, E. Aliot, C. Blomstrom-Lundqvist, L. Bossaert, G. Breithardt, P. Brugada, A.J. Camm, R. Cappato, S.M. Cobbe, C. Di Mario, et al. Task Force on Sudden Cardiac Death of the European Society of Cardiology Eur. Heart J., August 2, 2001; 22(16): 1374 - 1450. [PDF]
|
|
|
|
|
|
S. C. Smith Jr, J. T. Dove, A. K. Jacobs, J. Ward Kennedy, D. Kereiakes, M. J. Kern, R. E. Kuntz, J. J. Popma, H. V. Schaff, D. O. Williams, et al. ACC/AHA guidelines for percutaneous coronary intervention (revision of the 1993 PTCA guidelines): A report of the American College of Cardiology/ American Heart Association Task Force on practice guidelines (Committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty) endorsed by the Society for Cardiac Angiography and Interventions J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2239 - 2239. [Full Text] [PDF]
|
|
|
|
|
|
P Otasevic, A N Neskovic, Z Popovic, A Vlahovic, D Bojic, M Bojic, and A D Popovic Short early filling deceleration time on day 1 after acute myocardial infarction is associated with short and long term left ventricular remodelling Heart, May 1, 2001; 85(5): 527 - 532. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Hochman, L. A. Sleeper, H. D. White, V. Dzavik, S. C. Wong, V. Menon, J. G. Webb, R. Steingart, M. H. Picard, M. A. Menegus, et al. One-Year Survival Following Early Revascularization for Cardiogenic Shock JAMA, January 10, 2001; 285(2): 190 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O S Mortensen, J K Madsen, T Haghfelt, P Grande, K Saunamäki, S Haunsø, E Hjelms, H Arendrup, and t. D. study group Health related quality of life after conservative or invasive treatment of inducible postinfarction ischaemia Heart, November 1, 2000; 84(5): 535 - 540. [Abstract] [Full Text]
|
|
|
|
|
|
E. L. Hannan, M. J. Racz, D. T. Arani, T. J. Ryan, G. Walford, and B. D. McCallister Short- and long-term mortality for patients undergoing primary angioplasty for acute myocardial infarction J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1194 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A G C Sutton, P G Campbell, E D Grech, D J A Price, A Davies, J A Hall, M J Stewart, and M A de Belder Failure of thrombolysis: experience with a policy of early angiography and rescue angioplasty for electrocardiographic evidence of failed thrombolysis Heart, August 1, 2000; 84(2): 197 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C Bucher, P. Hengstler, C. Schindler, and G. H Guyatt Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomised controlled trials BMJ, July 8, 2000; 321(7253): 73 - 77. [Abstract] [Full Text]
|
|
|
|
|
|
L. Maillard, M. Hamon, K. Khalife, P. G. Steg, F. Beygui, J.-L. Guermonprez, C. M. Spaulding, J.-M. Boulenc, J. Lipiecki, A. Lafont, et al. A comparison of systematic stenting and conventional balloon angioplasty during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction J. Am. Coll. Cardiol., June 1, 2000; 35(7): 1729 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Akasaka, K. Yoshida, T. Kawamoto, S. Kaji, Y. Ueda, A. Yamamuro, T. Takagi, and T. Hozumi Relation of Phasic Coronary Flow Velocity Characteristics With TIMI Perfusion Grade and Myocardial Recovery After Primary Percutaneous Transluminal Coronary Angioplasty and Rescue Stenting Circulation, May 23, 2000; 101(20): 2361 - 2367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
ReneG. Favaloro Surgical treatment of acute myocardial infarction J. Am. Coll. Cardiol., April 1, 2000; 35(5_Suppl_B): 18B - 24B. [PDF]
|
|
|
|
 |
|
 Tackling myocardial infarction DTB, March 1, 2000; 38(3): 17 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yano, S. Kojima, T. Sugi, Y. Matsumoto, M. Kuramochi, and Y. Yoshitomi Long-Term Follow-up of Primary Stenting with Coil Stent in Acute Myocardial Infarction Angiology, February 1, 2000; 51(2): 107 - 114. [Abstract] [PDF]
|
|
|
|
|
|
R Zahn, R Schiele, K Seidl, K E Hauptmann, T Voigtlander, H-J Rupprecht, M Gottwik, H G Glunz, and J Senges Spectrum of reperfusion strategies and factors influencing the use of primary angioplasty in patients with acute myocardial infarction admitted to hospitals with the facilities to perform primary angioplasty Heart, October 1, 1999; 82(4): 420 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Hochman, L. A. Sleeper, J. G. Webb, T. A. Sanborn, H. D. White, J. D. Talley, C. E. Buller, A. K. Jacobs, J. N. Slater, J. Col, et al. Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock N. Engl. J. Med., August 26, 1999; 341(9): 625 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Frances, A. S. Go, K. W. Dauterman, K. Deosaransingh, D. L. Jung, S. Gettner, J. M. Newman, B. M. Massie, and W. S. Browner Outcome Following Acute Myocardial Infarction: Are Differences Among Physician Specialties the Result of Quality of Care or Case Mix? Arch Intern Med, July 12, 1999; 159(13): 1429 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Batchelor, E. D. Peterson, D. B. Mark, J. D. Knight, C. B. Granger, P. W. Armstrong, and R. M. Califf A comparison of U.S. and Canadian cardiac catheterization practices in detecting severe coronary artery disease after myocardial infarction: efficiency, yield and long-term implications J. Am. Coll. Cardiol., July 1, 1999; 34(1): 12 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Scanlon, D. P. Faxon, A.-M. Audet, B. Carabello, G. J. Dehmer, K. A. Eagle, R. D. Legako, D. F. Leon, J. A. Murray, S. E. Nissen, et al. ACC/AHA guidelines for coronary angiography: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography) developed in collaboration with the Society for Cardiac Angiography and Interventions J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1756 - 1824. [Full Text] [PDF]
|
|
|
|
|
|
E. Garcia, J. Elizaga, N. Perez-Castellano, J. A. Serrano, J. Soriano, M. Abeytua, J. Botas, R. Rubio, E. Lopez de Sa, J. L. Lopez-Sendon, et al. Primary angioplasty versus systemic thrombolysis in anterior myocardial infarction J. Am. Coll. Cardiol., March 1, 1999; 33(3): 605 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. O'Connor, H. B. Quinton, N. D. Traven, L. D. Ramunno, T. A. Dodds, T. A. Marciniak, and J. E. Wennberg Geographic Variation in the Treatment of Acute Myocardial Infarction: The Cooperative Cardiovascular Project JAMA, February 17, 1999; 281(7): 627 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ueda, S. Sakaki, I. Nochide, Y. Kumon, K. Kohno, and S. Ohta Angioplasty after Intra-Arterial Thrombolysis for Acute Occlusion of Intracranial Arteries Stroke, December 1, 1998; 29(12): 2568 - 2574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Horie, M. Takahashi, K. Minai, M. Izumi, A. Takaoka, M. Nozawa, H. Yokohama, T. Fujita, T. Sakamoto, O. Kito, et al. Long-Term Beneficial Effect of Late Reperfusion for Acute Anterior Myocardial Infarction With Percutaneous Transluminal Coronary Angioplasty Circulation, December 1, 1998; 98(22): 2377 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. Barron, L. J. Bowlby, T. Breen, W. J. Rogers, J. G. Canto, Y. Zhang, A. J. Tiefenbrunn, and W. D. Weaver Use of Reperfusion Therapy for Acute Myocardial Infarction in the United States : Data From the National Registry of Myocardial Infarction 2 Circulation, March 31, 1998; 97(12): 1150 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K Teo Recent advances: Cardiology BMJ, March 21, 1998; 316(7135): 911 - 915. [Full Text]
|
|
|
|
|
|
M. Eldar, M. Canetti, Z. Rotstein, V. Boyko, S. Gottlieb, E. Kaplinsky, and S. Behar Significance of Paroxysmal Atrial Fibrillation Complicating Acute Myocardial Infarction in the Thrombolytic Era Circulation, March 17, 1998; 97(10): 965 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Weaver, R. J. Simes, A. Betriu, C. L. Grines, F. Zijlstra, E. Garcia, L. Grinfeld, R. J. Gibbons, E. E. Ribeiro, M. A. DeWood, et al. Comparison of Primary Coronary Angioplasty and Intravenous Thrombolytic Therapy for Acute Myocardial Infarction: A Quantitative Review JAMA, December 17, 1997; 278(23): 2093 - 2098. [Abstract] [PDF]
|
|
|
|
|
|
S. Yusuf and J. Pogue Primary Angioplasty Compared With Thrombolytic Therapy for Acute Myocardial Infarction JAMA, December 17, 1997; 278(23): 2110 - 2111. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Hlatky Evaluation of Chest Pain in the Emergency Department N. Engl. J. Med., December 4, 1997; 337(23): 1687 - 1689. [Full Text]
|
|
|
|
|
|
I F Purcell, N Newall, and M Farrer Change in ST segment elevation 60 minutes after thrombolytic initiation predicts clinical outcome as accurately as later electrocardiographic changes Heart, November 1, 1997; 78(5): 465 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W SMYTH and J. M ELLIOTT Treating coronaries, at home or away? Heart, October 1, 1997; 78(4): 329 - 330. [Full Text] [PDF]
|
|
|
|
|
|
The Global Use of Strategies to Open Occluded Coro A Clinical Trial Comparing Primary Coronary Angioplasty with Tissue Plasminogen Activator for Acute Myocardial Infarction N. Engl. J. Med., June 5, 1997; 336(23): 1621 - 1628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Collins, R. Peto, C. Baigent, and P. Sleight Aspirin, Heparin, and Fibrinolytic Therapy in Suspected Acute Myocardial Infarction N. Engl. J. Med., March 20, 1997; 336(12): 847 - 860. [Full Text] [PDF]
|
|
|
|
|
|
N. R. Every, L. S. Parsons, M. Hlatky, J. S. Martin, W. D. Weaver, and The Myocardial Infarction Triage and Intervention A Comparison of Thrombolytic Therapy with Primary Coronary Angioplasty for Acute Myocardial Infarction N. Engl. J. Med., October 24, 1996; 335(17): 1253 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Bittl Advances in Coronary Angioplasty N. Engl. J. Med., October 24, 1996; 335(17): 1290 - 1302. [Full Text] [PDF]
|
|
|
|
|
|
R. A. Lange, L. D. Hillis, C. L. Grines, R. A. Lange, L. D. Hillis, and C. L. Grines Should Thrombolysis or Primary Angioplasty Be the Treatment of Choice for Acute Myocardial Infarction? N. Engl. J. Med., October 24, 1996; 335(17): 1311 - 1312. [Full Text] [PDF]
|
|
|
|
|
|
V. Pasceri, D. S. Pine, and T. A. Ports Subarachnoid Hemorrhage and Acute Myocardial Infarction N. Engl. J. Med., October 24, 1996; 335(17): 1320 - 1320. [Full Text]
|
|
|
|
|
|
L. Pilote, D. P. Miller, R. M. Califf, J. S. Rao, W. D. Weaver, and E. J. Topol Determinants of the Use of Coronary Angiography and Revascularization after Thrombolysis for Acute Myocardial Infarction N. Engl. J. Med., October 17, 1996; 335(16): 1198 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Stubbs, P. Collinson, D. Moseley, T. Greenwood, and M. Noble Prognostic Significance of Admission Troponin T Concentrations in Patients With Myocardial Infarction Circulation, September 15, 1996; 94(6): 1291 - 1297. [Abstract] [Full Text]
|
|
|
|
|
|
C. Bode, R. W. Smalling, G. Berg, C. Burnett, G. Lorch, J. M. Kalbfleisch, R. Chernoff, L. G. Christie, R. L. Feldman, A. A. Seals, et al. Randomized Comparison of Coronary Thrombolysis Achieved With Double-Bolus Reteplase (Recombinant Plasminogen Activator) and Front-Loaded, Accelerated Alteplase (Recombinant Tissue Plasminogen Activator) in Patients With Acute Myocardial Infarction Circulation, September 1, 1996; 94(5): 891 - 898. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Lanzkron and W. R. Bell State-of-the-Art Review : Management of Patients Who Require Invasive Procedures Immediately Following Thrombolytic Therapy Clinical and Applied Thrombosis/Hemostasis, July 1, 1996; 2(3): 158 - 163. [Abstract] [PDF]
|
|
|
|
|
|
M. Gawaz, F.-J. Neumann, I. Ott, A. Schiessler, and A. Schomig Platelet Function in Acute Myocardial Infarction Treated With Direct Angioplasty Circulation, January 15, 1996; 93(2): 229 - 237. [Abstract] [Full Text]
|
|