(Circulation. 1995;92:3323-3330.)
© 1995 American Heart Association, Inc.
Articles |
Tissue Factor Mediates Prolonged Procoagulant Activity on the Luminal Surface of Balloon-Injured Aortas in Rabbits
From the Department of Medicine, Washington University School of Medicine, St Louis, Mo, and Scripps Research Institute, La Jolla, Calif (W.R., T.S.E.).
Correspondence to Dana R. Abendschein, PhD, Cardiovascular Division, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8086, St Louis, MO 63110.
Background Activation of coagulation has been implicated in both acute thrombotic occlusion and restenosis after balloon angioplasty. However, concomitant administration of antithrombotic agents has thus far failed to prevent these complications. Importantly, the factors contributing to procoagulant activity of balloon-injured arteries over time have not been defined. This study was designed to determine the duration of procoagulant activity on the luminal surface of balloon-injured arteries and the relative roles of tissue factor and thrombin in this response.
Methods and Results Abdominal aortas in rabbits were subjected to
repetitive balloon hyperinflations sufficient to disrupt the internal
elastic lamina. Aortas were excised at <1, 2, 4, 8, 16, 24, 48, and 72
hours and 1, 2, and 4 weeks after injury; divided into segments; and
perfused with recalcified human pooled plasma (n=58) or plasma depleted
of vitamin K–dependent coagulation factors (n=27) or first
incubated
with a monoclonal antibody to rabbit tissue factor (n=33) followed by
perfusion with human plasma. Samples of the effluent and plasma
perfusate were collected over 10 minutes and assayed for
fibrinopeptide A (FPA) as an index of the rate of
thrombin-induced fibrin formation. FPA in the effluent from
segments perfused with recalcified plasma, expressed as a percentage of
FPA in the perfusate, was elevated for 16 hours after
balloon-induced injury and exhibited two distinct increases
occurring <1 hour (1297±473%, mean±SD, n=5) and 8
hours
(1052±330%, n=6) after injury (P
.000001 versus
uninjured
vessels). Preincubation of segments at these intervals with an antibody
to tissue factor markedly attenuated the increases in FPA, as did
perfusion of segments with plasma depleted of vitamin K–dependent
coagulation factors, indicating that the observed increases in FPA in
whole plasma did not result from preformed thrombin bound to the
injured vessel wall.
Conclusions Tissue factor–mediated coagulation appears to be primarily responsible for prolonged procoagulant activity of balloon-injured arteries.
Key Words: thrombosis • coagulation • angioplasty
This article has been cited by other articles:
 |
|
 |
|
  M. Jayachandran, A. Sanzo, W. G. Owen, and V. M. Miller Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1908 - H1916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Q. Wu and W. C. Aird Thrombin, TNF-{alpha}, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H873 - H885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Jeanpierre, T. Le Tourneau, I. Six, C. Zawadzki;, E. Van Belle, M. D. Ezekowitz, R. Bordet, S. Susen, B. Jude, and D. Corseaux Dietary Lipid Lowering Modifies Plaque Phenotype in Rabbit Atheroma After Angioplasty: A Potential Role of Tissue Factor Circulation, October 7, 2003; 108(14): 1740 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Dee and H. Samady Evolving Strategies for the Prevention and Treatment of Coronary Restenosis Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 281 - 293. [Abstract] [PDF]
|
|
|
|
 |
|
 D. D'Andrea, M. Ravera, P. Golino, A. Rosica, M. De Felice, M. Ragni, P. Cirillo, F. Vigorito, N. Corcione, P. Tommasini, et al. Induction of Tissue Factor in the Arterial Wall During Recurrent Thrombus Formation Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1684 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yin, C. Yutani, Y. Ikeda, K. Enjyoji, H. Ishibashi-Ueda, S. Yasuda, Y. Tsukamoto, H. Nonogi, Y. Kaneda, and H. Kato Tissue factor pathway inhibitor gene delivery using HVJ-AVE liposomes markedly reduces restenosis in atherosclerotic arteries Cardiovasc Res, December 1, 2002; 56(3): 454 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cavusoglu, I. Chen, J. Rappaport, and J. D. Marmur Inhibition of Tissue Factor Gene Induction and Activity Using a Hairpin Ribozyme Circulation, May 14, 2002; 105(19): 2282 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Kim, P. L. Walinsky, F. D. Kolodgie, C. Bian, J. L. Sperry, C. B. Deming, E. A. Peck, J. G. Shake, G. B. Ang, R. H. Sohn, et al. Early Loss of Thrombomodulin Expression Impairs Vein Graft Thromboresistance: Implications for Vein Graft Failure Circ. Res., February 8, 2002; 90(2): 205 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H.M Moons, M. Levi, and R. J.G Peters Tissue factor and coronary artery disease Cardiovasc Res, February 1, 2002; 53(2): 313 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zoldhelyi, Z.-Q. Chen, H. S. Shelat, J. M. McNatt, and J. T. Willerson Local gene transfer of tissue factor pathway inhibitor regulates intimal hyperplasia in atherosclerotic arteries PNAS, March 27, 2001; 98(7): 4078 - 4083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nishibe, G. Parry, A. Ishida, S. Aziz, J. Murray, Y. Patel, S. Rahman, K. Strand, K. Saito, Y. Saito, et al. Oncostatin M promotes biphasic tissue factor expression in smooth muscle cells: evidence for Erk-1/2 activation Blood, February 1, 2001; 97(3): 692 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Maderna, C. Godson, G. Hannify, M. Murphy, and H. R. Brady Influence of lipoxin A4 and other lipoxygenase-derived eicosanoids on tissue factor expression Am J Physiol Cell Physiol, October 1, 2000; 279(4): C945 - C953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Schecter, B. Spirn, M. Rossikhina, P. L. A. Giesen, V. Bogdanov, J. T. Fallon, E. A. Fisher, L. M. Schnapp, Y. Nemerson, and M. B. Taubman Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells Circ. Res., July 21, 2000; 87(2): 126 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hasenstab, H. Lea, C. E. Hart, S. Lok, and A. W. Clowes Tissue Factor Overexpression in Rat Arterial Neointima Models Thrombosis and Progression of Advanced Atherosclerosis Circulation, June 6, 2000; 101(22): 2651 - 2657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Corseaux, T. Meurice, I. Six, L. Rugeri, M. D. Ezekowitz, P. Rouvier, R. Bordet, C. Bauters, and B. Jude Basic Fibroblast Growth Factor Increases Tissue Factor Expression in Circulating Monocytes and in Vascular Wall Circulation, April 25, 2000; 101(16): 2000 - 2006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Saitoh, H. Kishida, Y. Tsukada, Y. Fukuma, J. Sano, M. Yasutake, N. Fukuma, Y. Kusama, and H. Hayakawa Clinical significance of increased plasma concentration of macrophage colony-stimulating factor in patients with angina pectoris J. Am. Coll. Cardiol., March 1, 2000; 35(3): 655 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Arnaud, V. Barbalat, V. Nicaud, F. Cambien, A. Evans, C. Morrison, D. Arveiler, G. Luc, J.-B. Ruidavets, J. Emmerich, et al. Polymorphisms in the 5' Regulatory Region of the Tissue Factor Gene and the Risk of Myocardial Infarction and Venous Thromboembolism : The ECTIM and PATHROS Studies Arterioscler. Thromb. Vasc. Biol., March 1, 2000; 20(3): 892 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Klement, P. Liao, and L. Bajzar A Novel Approach to Arterial Thrombolysis Blood, October 15, 1999; 94(8): 2735 - 2743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Becker, F. A. Spencer, Y. Li, S. P. Ball, Y. Ma, T. Hurley, and J. Hebert Thrombin generation after the abrupt cessation of intravenous unfractionated heparin among patients with acute coronary syndromes: Potential mechanisms for heightened prothrombotic potential J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1020 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Han, T. J. Girard, P. Baum, D. R. Abendschein, and G. J. Broze Jr Structural Requirements for TFPI-Mediated Inhibition of Neointimal Thickening After Balloon Injury in the Rat Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2563 - 2567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. St. Pierre, L.-Y. Yang, K. Tamirisa, D. Scherrer, P. De Ciechi, P. Eisenberg, E. Tolunay, and D. Abendschein Tissue Factor Pathway Inhibitor Attenuates Procoagulant Activity and Upregulation of Tissue Factor at the Site of Balloon-Induced Arterial Injury in Pigs Arterioscler. Thromb. Vasc. Biol., September 1, 1999; 19(9): 2263 - 2268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Gertz, J. T. Fallon, R. Gallo, M. B. Taubman, S. Banai, W. L. Barry, L. W. Gimple, Y. Nemerson, S. Thiruvikraman, S. S. Naidu, et al. Hirudin Reduces Tissue Factor Expression in Neointima After Balloon Injury in Rabbit Femoral and Porcine Coronary Arteries Circulation, August 11, 1998; 98(6): 580 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Courtman, S. M. Schwartz, and C. E. Hart Sequential Injury of the Rabbit Abdominal Aorta Induces Intramural Coagulation and Luminal Narrowing Independent of Intimal Mass : Extrinsic Pathway Inhibition Eliminates Luminal Narrowing Circ. Res., May 19, 1998; 82(9): 996 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ghigliotti, A. R. Waissbluth, C. Speidel, D. R. Abendschein, and P. R. Eisenberg Prolonged Activation of Prothrombin on the Vascular Wall After Arterial Injury Arterioscler. Thromb. Vasc. Biol., February 1, 1998; 18(2): 250 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Schecter, B. J. Rollins, Y. J. Zhang, I. F. Charo, J. T. Fallon, M. Rossikhina, P. L. A. Giesen, Y. Nemerson, and M. B. Taubman Tissue Factor Is Induced by Monocyte Chemoattractant Protein-1 in Human Aortic Smooth Muscle and THP-1 Cells J. Biol. Chem., November 7, 1997; 272(45): 28568 - 28573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Oltrona, C. M. Speidel, D. Recchia, S. A. Wickline, P. R. Eisenberg, and D. R. Abendschein Inhibition of Tissue Factor–Mediated Coagulation Markedly Attenuates Stenosis After Balloon-Induced Arterial Injury in Minipigs Circulation, July 15, 1997; 96(2): 646 - 652. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Channon, G. J. Fulton, M. G. Davies, K. G. Peters, M. D. Ezekowitz, P.-O. Hagen, and B. H. Annex Modulation of Tissue Factor Protein Expression in Experimental Venous Bypass Grafts Arterioscler. Thromb. Vasc. Biol., July 1, 1997; 17(7): 1313 - 1319. [Abstract] [Full Text]
|
|
|
|
|
|
P. R. Moreno, V. H. Bernardi, J. Lopez-Cuellar, J. B. Newell, C. McMellon, H. K. Gold, I. F. Palacios, V. Fuster, and J. T. Fallon Macrophage Infiltration Predicts Restenosis After Coronary Intervention in Patients With Unstable Angina Circulation, December 15, 1996; 94(12): 3098 - 3102. [Abstract] [Full Text]
|
|
|
|
|
|
A. Y. Kim, P. L. Walinsky, F. D. Kolodgie, C. Bian, J. L. Sperry, C. B. Deming, E. A. Peck, J. G. Shake, G. B. Ang, R. H. Sohn, et al. Early Loss of Thrombomodulin Expression Impairs Vein Graft Thromboresistance: Implications for Vein Graft Failure Circ. Res., February 8, 2002; 90(2): 205 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Singh, S. Pan, C. S. Mueske, T. Witt, L. S. Kleppe, T. E. Peterson, A. Slobodova, J.-Y. Chang, N. M. Caplice, and R. D. Simari Role for Tissue Factor Pathway in Murine Model of Vascular Remodeling Circ. Res., July 6, 2001; 89(1): 71 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Herkert, I. Diebold, R. P. Brandes, J. Hess, R. Busse, and A. Gorlach NADPH Oxidase Mediates Tissue Factor-Dependent Surface Procoagulant Activity by Thrombin in Human Vascular Smooth Muscle Cells Circulation, April 30, 2002; 105(17): 2030 - 2036. [Abstract] [Full Text] [PDF]
|
|