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(Circulation. 1996;93:34-41.)
© 1996 American Heart Association, Inc.
Articles |
Progression of Coronary Artery Disease Predicts Clinical Coronary Events
Long-term Follow-up From the Cholesterol Lowering Atherosclerosis Study
From the Atherosclerosis Research Unit and Statistical Consultation and Research Center, Departments of Preventive Medicine (S.P.A., W.J.M., L.L., H.N.H.) and Medicine (L.C.-H., D.H.B., H.N.H.), University of Southern California, Los Angeles; and Jet Propulsion Laboratory (A.M.S., R.H.S.), Pasadena, Calif.
Background Progression of coronary artery disease is assumed to be a surrogate end point for clinical coronary events. Because no single method or measure for a coronary angiographic end point is uniformly accepted as optimal, the utility and validity of surrogate end points for predicting clinical coronary events remain unsettled.
Methods and Results The Cholesterol Lowering Atherosclerosis Study randomized 162 nonsmoking, 40- to 59-year-old men with previous coronary artery bypass graft surgery to colestipol/niacin plus diet or placebo plus diet. Atherosclerosis change on 2-year coronary angiograms was evaluated by a consensus panel and by quantitative coronary angiography (average per-subject change in percent diameter stenosis [%S] and minimum lumen diameter [MLD]). With all three end points, the benefit of colestipol/niacin treatment on coronary artery atherosclerosis has been reported. Annual follow-up for an average of 7 years (range, 6.3 months to 10 years) has been carried out on all subjects who completed the 2-year angiogram. Clinical coronary events (need for revascularization, nonfatal acute myocardial infarction, and coronary death) have been documented. Risk of clinical coronary events was positively related to coronary lesion progression for all three surrogate end points (P<.05). New lesion formation in bypass grafts (P=.02) and progression of mild/moderate lesions (<50%S) were predictive of clinical coronary events (P<.01). Change in MLD contributed significantly to the prediction of clinical coronary events beyond a model with %S alone (P<.05).
Conclusions In this population of nonsmoking men with previous bypass surgery, both the consensus panel– and quantitative coronary angiography–based end points of coronary artery disease progression predict clinical coronary events. Subjects who demonstrate greater coronary artery lesion progression have an increased risk of future clinical coronary events. Design of shorter, smaller trials of antiatherosclerotic agents is justified.
Key Words: angiography • atherosclerosis • follow-up studies • coronary disease
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|
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|
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|
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|
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|
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|
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|
|
|
|
|
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|
|
|
|
|
|
References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]
|
|
|
|
|
|
D. D. Waters, E. L. Alderman, J. Hsia, B. V. Howard, F. R. Cobb, W. J. Rogers, P. Ouyang, P. Thompson, J. C. Tardif, L. Higginson, et al. Effects of Hormone Replacement Therapy and Antioxidant Vitamin Supplements on Coronary Atherosclerosis in Postmenopausal Women: A Randomized Controlled Trial JAMA, November 20, 2002; 288(19): 2432 - 2440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Taylor, S. M. Kent, P. J. Flaherty, L. C. Coyle, T. T. Markwood, and M. N. Vernalis ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: A Randomized Trial Comparing the Effects of Atorvastatin and Pravastatin on Carotid Intima Medial Thickness Circulation, October 15, 2002; 106(16): 2055 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Jukema, Y. F. C. Smets, J. W. van der Pijl, A. H. Zwinderman, H. W. Vliegen, J. Ringers, J. H. C. Reiber, H. H. P. J. Lemkes, E. E. van der Wall, and J. W. de Fijter Impact of Simultaneous Pancreas and Kidney Transplantation on Progression of Coronary Atherosclerosis in Patients With End-Stage Renal Failure due to Type 1 Diabetes Diabetes Care, May 1, 2002; 25(5): 906 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Wong, H. Li, W. W.M. Lam, Y. L. Chan, and R. Kay Progression of Middle Cerebral Artery Occlusive Disease and Its Relationship With Further Vascular Events After Stroke Stroke, February 1, 2002; 33(2): 532 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Arenillas, C. A. Molina, J. Montaner, S. Abilleira, M. A. Gonzalez-Sanchez;, and J. Alvarez-Sabin Progression and Clinical Recurrence of Symptomatic Middle Cerebral Artery Stenosis: A Long-Term Follow-Up Transcranial Doppler Ultrasound Study Stroke, December 1, 2001; 32(12): 2898 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Freedman Antioxidant versus Lipid-Altering Therapy -- Some Answers, More Questions N. Engl. J. Med., November 29, 2001; 345(22): 1636 - 1637. [Full Text] [PDF]
|
|
|
|
|
|
C. W. White, F. L. Gobel, L. Campeau, G. L. Knatterud, S. A. Forman, J. S. Forrester, N. L. Geller, J. A. Herd, A. Hickey, B. J. Hoogwerf, et al. Effect of an Aggressive Lipid-Lowering Strategy on Progression of Atherosclerosis in the Left Main Coronary Artery From Patients in the Post Coronary Artery Bypass Graft Trial Circulation, November 27, 2001; 104(22): 2660 - 2665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zambon, S. S. Deeb, B. G. Brown, J. E. Hokanson, and J. D. Brunzell Common Hepatic Lipase Gene Promoter Variant Determines Clinical Response to Intensive Lipid-Lowering Treatment Circulation, February 13, 2001; 103(6): 792 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Hodis Myocardial Ischemia and Lipoprotein Lipase Activity Circulation, October 3, 2000; 102(14): 1600 - 1601. [Full Text] [PDF]
|
|
|
|
|
|
D. M. Herrington, D. M. Reboussin, K. B. Brosnihan, P. C. Sharp, S. A. Shumaker, T. E. Snyder, C. D. Furberg, G. J. Kowalchuk, T. D. Stuckey, W. J. Rogers, et al. Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis N. Engl. J. Med., August 24, 2000; 343(8): 522 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Waters and R. R. Azar Postscripts From the Post Coronary Artery Bypass Graft Trial : The Sustained Benefit of More Aggressive Cholesterol Lowering and the Enigma of Low-Dose Anticoagulation Circulation, July 11, 2000; 102(2): 144 - 146. [Full Text] [PDF]
|
|
|
|
|
|
G. L. Knatterud, Y. Rosenberg, L. Campeau, N. L. Geller, D. B. Hunninghake, S. A. Forman, J. S. Forrester, F. L. Gobel, J. A. Herd, A. Hickey, et al. Long-Term Effects on Clinical Outcomes of Aggressive Lowering of Low-Density Lipoprotein Cholesterol Levels and Low-Dose Anticoagulation in the Post Coronary Artery Bypass Graft Trial Circulation, July 11, 2000; 102(2): 157 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamagishi, M. Terashima, K. Awano, M. Kijima, S. Nakatani, S. Daikoku, K. Ito, Y. Yasumura, and K. Miyatake Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome J. Am. Coll. Cardiol., January 1, 2000; 35(1): 106 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Mann and M J Davies Mechanisms of progression in native coronary artery disease: role of healed plaque disruption Heart, September 1, 1999; 82(3): 265 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Hodis Triglyceride-Rich Lipoprotein Remnant Particles and Risk of Atherosclerosis Circulation, June 8, 1999; 99(22): 2852 - 2854. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Scanlon, D. P. Faxon, A.-M. Audet, B. Carabello, G. J. Dehmer, K. A. Eagle, R. D. Legako, D. F. Leon, J. A. Murray, S. E. Nissen, et al. ACC/AHA guidelines for coronary angiography: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography) developed in collaboration with the Society for Cardiac Angiography and Interventions J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1756 - 1824. [Full Text] [PDF]
|
|
|
|
|
|
C. M. Ballantyne, J. A. Herd, L. L. Ferlic, J. K. Dunn, J. A. Farmer, P. H. Jones, J. R. Schein, and A. M. Gotto Jr Influence of Low HDL on Progression of Coronary Artery Disease and Response to Fluvastatin Therapy Circulation, February 16, 1999; 99(6): 736 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Syvanne, M. S. Nieminen, M. H. Frick, H. Kauma, S. Majahalme, V. Virtanen, Y. A. Kesaniemi, A. Pasternack, C. Ehnholm, and M.-R. Taskinen Associations Between Lipoproteins and the Progression of Coronary and Vein-Graft Atherosclerosis in a Controlled Trial With Gemfibrozil in Men With Low Baseline Levels of HDL Cholesterol Circulation, November 10, 1998; 98(19): 1993 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Akins, T. K. Pilgram, D. T. Cross III, and C. J. Moran Natural History of Stenosis From Intracranial Atherosclerosis by Serial Angiography Stroke, February 1, 1998; 29(2): 433 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Kuivenhoven, J. W. Jukema, A. H. Zwinderman, P. de Knijff, R. McPherson, A. V.G. Bruschke, K. I. Lie, J. J.P. Kastelein, and The Regression Growth Evaluation Statin Study Grou The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis N. Engl. J. Med., January 8, 1998; 338(2): 86 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Frick, M. Syvanne, M. S. Nieminen, H. Kauma, S. Majahalme, V. Virtanen, Y. A. Kesaniemi, A. Pasternack, and M.-R. Taskinen Prevention of the Angiographic Progression of Coronary and Vein-Graft Atherosclerosis by Gemfibrozil After Coronary Bypass Surgery in Men With Low Levels of HDL Cholesterol Circulation, October 7, 1997; 96(7): 2137 - 2143. [Abstract] [Full Text]
|
|
|
|
|
|
P. C. Avila, L. Campeau, G. L. Knatterud, M. Domanski, D. B. Hunninghake, and The Post Coronary Artery Bypass Graft Trial Invest Prevention of Atherosclerosis in Coronary-Artery Bypass Grafts N. Engl. J. Med., June 19, 1997; 336(25): 1839 - 1840. [Full Text]
|
|
|
|
|
|
S. P. Azen, D. Qian, W. J. Mack, A. Sevanian, R. H. Selzer, C.-R. Liu, C.-H. Liu, and H. N. Hodis Effect of Supplementary Antioxidant Vitamin Intake on Carotid Arterial Wall Intima-Media Thickness in a Controlled Clinical Trial of Cholesterol Lowering Circulation, November 15, 1996; 94(10): 2369 - 2372. [Abstract] [Full Text]
|
|
|
|
|
|
J. W. Jukema, A. J. van Boven, B. Groenemeijer, A. H. Zwinderman, J. H.C. Reiber, A. V.G. Bruschke, J.A. Henneman, G.P. Molhoek, T. Bruin, H. Jansen, et al. The Asp9 Asn Mutation in the Lipoprotein Lipase Gene Is Associated With Increased Progression of Coronary Atherosclerosis Circulation, October 15, 1996; 94(8): 1913 - 1918. [Abstract] [Full Text]
|
|
|
|
|
|
M. J. Davies Stability and Instability: Two Faces of Coronary Atherosclerosis: The Paul Dudley White Lecture 1995 Circulation, October 15, 1996; 94(8): 2013 - 2020. [Full Text]
|
|
|
|
|
|
D. Waters, J. Lesperance, P. Gladstone, S. J. Boccuzzi, T. Cook, R. Hudgin, G. Krip, and L. Higginson Effects of Cigarette Smoking on the Angiographic Evolution of Coronary Atherosclerosis: A Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) Substudy Circulation, August 15, 1996; 94(4): 614 - 621. [Abstract] [Full Text]
|
|
|
|
|
|
W. J. Mack, R. M. Krauss, and H. N. Hodis Lipoprotein Subclasses in the Monitored Atherosclerosis Regression Study (MARS) : Treatment Effects and Relation to Coronary Angiographic Progression Arterioscler Thromb Vasc Biol, May 1, 1996; 16(5): 697 - 704. [Abstract] [Full Text]
|
|