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(Circulation. 1996;93:1951-1953.)
© 1996 American Heart Association, Inc.
Articles |
Predictive Value of Electron Beam Computed Tomography of the Coronary Arteries
19-Month Follow-up of 1173 Asymptomatic Subjects
From the Departments of Preventive Cardiology (Y.A., L.A.S., G.L., A.D.G.) and Radiology (K.G., A.L., S.S.), St Francis Hospital, Roslyn, NY.
Correspondence to Yadon Arad, MD, Preventive Cardiology, St Francis Hospital, 100 Port Washington Blvd, Roslyn, NY 11576.
Background Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease.
Methods and Results We followed 1173 asymptomatic patients who underwent EBCT between September 1993 and March 1994. During average follow-up of 19 months, 18 subjects had 26 cardiovascular events: 1 death, 7 myocardial infarctions, 8 coronary artery bypass graft procedures, 9 coronary angioplasties, and 1 nonhemorrhagic stroke. For CAC score thresholds of 100, 160, and 680, EBCT had sensitivities of 89%, 89%, and 50% and specificities of 77%, 82%, and 95%, respectively. Odds ratios ranged from 20.0 to 35.4 (P<.00001 for all).
Conclusions Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects.
Key Words: tomography • calcium • atherosclerosis • coronary disease • follow-up studies
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H. M. Colhoun, L. M. Scheek, M. B. Rubens, T. Van Gent, S. R. Underwood, J. H. Fuller, and A. Van Tol Lipid Transfer Protein Activities in Type 1 Diabetic Patients Without Renal Failure and Nondiabetic Control Subjects and Their Association With Coronary Artery Calcification Diabetes, March 1, 2001; 50(3): 652 - 659. [Abstract] [Full Text]
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R. Haberl, A. Becker, A. Leber, A. Knez, C. Becker, C. Lang, R. Bruning, M. Reiser, and G. Steinbeck Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: results of 1,764 patients J. Am. Coll. Cardiol., February 1, 2001; 37(2): 451 - 457. [Abstract] [Full Text] [PDF]
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W. Moshage, S. Achenbach, and W. G. Daniel Novel approaches to the non-invasive diagnosis of coronary-artery disease Nephrol. Dial. Transplant., January 1, 2001; 16(1): 21 - 28. [Full Text] [PDF]
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A Farzaneh-Far, D Proudfoot, C Shanahan, and P L Weissberg Vascular and valvar calcification: recent advances Heart, January 1, 2001; 85(1): 13 - 17. [Full Text]
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L. F. Bielak, P. F. Sheedy II, and P. A. Peyser Coronary Artery Calcification Measured at Electron-Beam CT: Agreement in Dual Scan Runs and Change over Time Radiology, January 1, 2001; 218(1): 224 - 229. [Abstract] [Full Text]
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H. M. Colhoun, M. B. Rubens, S. R. Underwood, and J. H. Fuller The effect of type 1 diabetes mellitus on the gender difference in coronary artery calcification J. Am. Coll. Cardiol., December 1, 2000; 36(7): 2160 - 2167. [Abstract] [Full Text] [PDF]
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T. Callister, W. Janowitz, and P. Raggi Sensitivity of Two Electron Beam Tomography Protocols for the Detection and Quantification of Coronary Artery Calcium Am. J. Roentgenol., December 1, 2000; 175(6): 1743 - 1746. [Abstract] [Full Text] [PDF]
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B. Lu, R. Dai, H. Bai, S. He, B. Jing, N. Zhuang, R. Gao, Y. Yang, J. Chen, and M. J. Budoff Evaluation of Electron Beam Tomographic Coronary Arteriography with Three-Dimensional Reconstruction in Healthy Subjects Angiology, November 1, 2000; 51(11): 895 - 904. [Abstract] [PDF]
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Y. Arad, L. A. Spadaro, K. Goodman, D. Newstein, and A. D. Guerci Prediction of coronary events with electron beam computed tomography J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1253 - 1260. [Abstract] [Full Text] [PDF]
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C. N. H. Enzweiler, D. E. Kivelitz, T. H. Wiese, M. Taupitz, S. Höhn, A. C. Borges, L. Pietsch, P. Dohmen, G. Baumann, and B. Hamm Coronary Artery Bypass Grafts: Improved Electron-Beam Tomography by Prolonging Breath Holds with Preoxygenation Radiology, October 1, 2000; 217(1): 278 - 283. [Abstract] [Full Text]
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L. F. Bielak, G. G. Klee, P. F. Sheedy II, S. T. Turner, R. S. Schwartz, and P. A. Peyser Association of Fibrinogen With Quantity of Coronary Artery Calcification Measured by Electron Beam Computed Tomography Arterioscler Thromb Vasc Biol, September 1, 2000; 20(9): 2167 - 2171. [Abstract] [Full Text] [PDF]
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L. F. Bielak, J. A. Rumberger, P. F. Sheedy II, R. S. Schwartz, and P. A. Peyser Probabilistic Model for Prediction of Angiographically Defined Obstructive Coronary Artery Disease Using Electron Beam Computed Tomography Calcium Score Strata Circulation, July 25, 2000; 102(4): 380 - 385. [Abstract] [Full Text] [PDF]
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W. R. Janowitz, R. C. Detrano, N. D. Wong, T. M. Doherty, R. M. Shavelle, W. Tang, L. E. Ginzton, M. J. Budoff, and K. A. Narahara Coronary Calcium Does Not Accurately Predict Near-Term Future Coronary Events in High-Risk Adults Response Circulation, July 11, 2000; 102 (2): e20 - e21. [Full Text] [PDF]
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R. A. O'Rourke, B. H. Brundage, V. F. Froelicher, P. Greenland, S. M. Grundy, R. Hachamovitch, G. M. Pohost, L. J. Shaw, W. S. Weintraub, W. L. Winters Jr, et al. American College of Cardiology/American Heart Association Expert Consensus Document on Electron-Beam Computed Tomography for the Diagnosis and Prognosis of Coronary Artery Disease : Committee Members Circulation, July 4, 2000; 102(1): 126 - 140. [Full Text] [PDF]
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R. F. Redberg, N. Rifai, L. Gee, and P. M. Ridker Lack of association of C-reactive protein and coronary calcium by electron beam computed tomography in postmenopausal women: implications for coronary artery disease screening J. Am. Coll. Cardiol., July 1, 2000; 36(1): 39 - 43. [Abstract] [Full Text] [PDF]
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R. A. O'Rourke, B. H. Brundage, V. F. Froelicher, P. Greenland, S. M. Grundy, R. Hachamovitch, G. M. Pohost, L. J. Shaw, W. S. Weintraub, W. L. Winters Jr, et al. American College of Cardiology/American Heart Association expert consensus document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease J. Am. Coll. Cardiol., July 1, 2000; 36(1): 326 - 340. [Full Text] [PDF]
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W. J. Rogers, J. W. Prichard, Y.-L. Hu, P. R. Olson, D. H. Benckart, C. M. Kramer, D. A. Vido, and N. Reichek Characterization of Signal Properties in Atherosclerotic Plaque Components by Intravascular MRI Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1824 - 1830. [Abstract] [Full Text] [PDF]
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C. Iribarren, S. Sidney, B. Sternfeld, and W. S. Browner Calcification of the Aortic Arch: Risk Factors and Association With Coronary Heart Disease, Stroke, and Peripheral Vascular Disease JAMA, June 7, 2000; 283(21): 2810 - 2815. [Abstract] [Full Text] [PDF]
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F. D. Knollmann, W. Bocksch, S. Spiegelsberger, R. Hetzer, R. Felix, and M. Hummel Electron-Beam Computed Tomography in the Assessment of Coronary Artery Disease After Heart Transplantation Circulation, May 2, 2000; 101(17): 2078 - 2082. [Abstract] [Full Text] [PDF]
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 R Erbel, A Schmermund, S Mohlenkamp, S Sack, and D Baumgart Electron-beam computed tomography for detection of early signs of coronary arteriosclerosis Eur. Heart J., May 1, 2000; 21(9): 720 - 732. [PDF]
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J. J. Carr, J. R. Crouse III, D. C. Goff Jr., R. B. D'Agostino Jr., N. P. Peterson, and G. L. Burke Evaluation of Subsecond Gated Helical CT for Quantification of Coronary Artery Calcium and Comparison with Electron Beam CT Am. J. Roentgenol., April 1, 2000; 174(4): 915 - 921. [Abstract] [Full Text] [PDF]
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A. J. Taylor, A. P. Burke, P. G. O’Malley, A. Farb, G. T. Malcom, J. Smialek, and R. Virmani A Comparison of the Framingham Risk Index, Coronary Artery Calcification, and Culprit Plaque Morphology in Sudden Cardiac Death Circulation, March 21, 2000; 101(11): 1243 - 1248. [Abstract] [Full Text] [PDF]
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