(Circulation. 1996;93:2178-2187.)
© 1996 American Heart Association, Inc.
Articles |
Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries
Presented at the 67th Scientific Sessions of the American Heart Association, Dallas, Tex, November 15, 1994, and at Experimental Biology 95, Atlanta, Ga, April 12, 1995, and published in abstract form (Circulation 1994;90[pt 2]:I-392 and FASEB J 1995;9:A845).
From the Department of Medicine, Emory University, Atlanta, Ga (N.A.S., G.D.C., C.E.R., B.D., J.N.W.) and Amgen Pharmaceuticals Inc, Thousand Oaks, Calif (F.H.M., L.S.).
Correspondence to Josiah N. Wilcox, PhD, Emory University, Box AJ, Hematology, 1639 Pierce Dr, Room 1115 WMRB, Atlanta, GA 30322. E-mail medjnw@emory.edu.
Background In the present series of experiments, we examined the onset of cell proliferation and growth factor expression after balloon overstretch injury to porcine coronary arteries.
Methods and Results Domestic juvenile swine underwent balloon overstretch injury to the left anterior descending and circumflex coronary arteries with standard percutaneous transluminal coronary angioplasty balloon catheters. To identify proliferating cells, 5-bromo-2-deoxyuridine (BrDU) was administered over a period of 24 hours before the animals were killed at either 1, 3, 7, or 14 days after injury. Immunohistochemistry was performed with monoclonal antibodies to BrDU and smooth muscle cell markers. Three days after injury, a large number of proliferating cells were located in the adventitia, with significantly fewer positive cells found in the media and lumen. Seven days after injury, proliferating cells were found primarily in the neointima, extending along the luminal surface. In situ hybridization for PDGF A-chain and ß-receptor mRNAs revealed that the expression of these two genes was closely correlated with the sites of proliferation at each time point. Studies in which BrDU was injected between days 2 and 3 and the animals were killed on day 14 suggested that the proliferating adventitial cells may migrate into the neointima.
Conclusions These data suggest that adventitial
myofibroblasts contribute to the process of vascular lesion formation
by proliferating, synthesizing growth factors, and possibly migrating
into the neointima. Increased synthesis of 
-smooth
muscle actin observed in the adventitial cells after
arterial injury may constrict the injured vessel and
contribute to the process of arterial remodeling and late
lumen loss after angioplasty.
Key Words: adventitia • angioplasty • restenosis • muscle, smooth • remodeling
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E. Rodriguez, E. H. Lambert, M. G. Magno, and J. D. Mannion Contractile smooth muscle cell apoptosis early after saphenous vein grafting Ann. Thorac. Surg., October 1, 2000; 70(4): 1145 - 1152. [Abstract] [Full Text] [PDF]
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K. K. Griendling, D. Sorescu, B. Lassegue, and M. Ushio-Fukai Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology Arterioscler Thromb Vasc Biol, October 1, 2000; 20(10): 2175 - 2183. [Abstract] [Full Text] [PDF]
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I. P. Kay, M. Sabate, M. A. Costa, K. Kozuma, M. Albertal, W. J. van der Giessen, A. J. Wardeh, J. M. R. Ligthart, V. M. A. Coen, P. C. Levendag, et al. Positive Geometric Vascular Remodeling Is Seen After Catheter-Based Radiation Followed by Conventional Stent Implantation but Not After Radioactive Stent Implantation Circulation, September 19, 2000; 102(12): 1434 - 1439. [Abstract] [Full Text] [PDF]
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V. M. Miller Vascular Control During Pregnancy : Extending Experimental Findings to Humans Circ. Res., September 1, 2000; 87(5): 344 - 345. [Full Text] [PDF]
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A. F. Drew, H. L. Tucker, K. W. Kombrinck, D. I. Simon, T. H. Bugge, and J. L. Degen Plasminogen Is a Critical Determinant of Vascular Remodeling in Mice Circ. Res., July 21, 2000; 87(2): 133 - 139. [Abstract] [Full Text] [PDF]
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M. V. Autieri, C. Carbone, and A. Mu Expression of Allograft Inflammatory Factor-1 Is a Marker of Activated Human Vascular Smooth Muscle Cells and Arterial Injury Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1737 - 1744. [Abstract] [Full Text] [PDF]
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G. Li, Y.-F. Chen, S. S. Kelpke, S. Oparil, and J. A. Thompson Estrogen Attenuates Integrin-{beta}3-Dependent Adventitial Fibroblast Migration After Inhibition of Osteopontin Production in Vascular Smooth Muscle Cells Circulation, June 27, 2000; 101(25): 2949 - 2955. [Abstract] [Full Text] [PDF]
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R. S. Scotland, P. J.T. Vallance, and A. Ahluwalia Endogenous factors involved in regulation of tone of arterial vasa vasorum: implications for conduit vessel physiology Cardiovasc Res, June 1, 2000; 46(3): 403 - 411. [Abstract] [Full Text] [PDF]
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M. Sabate, J. P. A. Marijnissen, S. G. Carlier, I. P. Kay, W. J. van der Giessen, V. L. M. A. Coen, J. M. R. Ligthart, E. Boersma, M. A. Costa, P. C. Levendag, et al. Residual Plaque Burden, Delivered Dose, and Tissue Composition Predict 6-Month Outcome After Balloon Angioplasty and {beta}-Radiation Therapy Circulation, May 30, 2000; 101(21): 2472 - 2477. [Abstract] [Full Text] [PDF]
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R. E. Kuntz and D. S. Baim Prevention of Coronary Restenosis : The Evolving Evidence Base for Radiation Therapy Circulation, May 9, 2000; 101(18): 2130 - 2133. [Full Text] [PDF]
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H. Otani, H. Ohmiya, R. Hattori, H. Fujii, H. Ninomiya, M. Kido, H. Kawaguchi, M. Osako, H. Imamura, T. Ohta, et al. Potential role of vacuolar H+-adenosine triphosphatase in neointimal formation in cultured human saphenous vein J. Thorac. Cardiovasc. Surg., May 1, 2000; 119(5): 998 - 1007. [Abstract] [Full Text] [PDF]
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T. M. Calderon, S. D. Gertz, I. J. Sarembock, J. A. Berliner, J. T. Fallon, M. B. Taubman, and J. W. Berman Induction of IG9 Monocyte Adhesion Molecule Expression in Smooth Muscle and Endothelial Cells After Balloon Arterial Injury in Cholesterol-Fed Rabbits Arterioscler Thromb Vasc Biol, May 1, 2000; 20(5): 1293 - 1300. [Abstract] [Full Text] [PDF]
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 M. Gu, J. Lynch, and P. Brecher Nitric Oxide Increases p21Waf1/Cip1 Expression by a cGMP-dependent Pathway That Includes Activation of Extracellular Signal-regulated Kinase and p70S6k J. Biol. Chem., April 6, 2000; 275(15): 11389 - 11396. [Abstract] [Full Text] [PDF]
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S. Ishiwata, S. Verheye, K. A. Robinson, M. Y. Salame, H. de Leon, S. B. King III, and N. A. F. Chronos Inhibition of neointima formation by tranilast in pig coronary arteries after balloon angioplasty and stent implantation J. Am. Coll. Cardiol., April 1, 2000; 35(5): 1331 - 1337. [Abstract] [Full Text] [PDF]
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G. Li, S.-J. Chen, S. Oparil, Y.-F. Chen, and J. A. Thompson Direct In Vivo Evidence Demonstrating Neointimal Migration of Adventitial Fibroblasts After Balloon Injury of Rat Carotid Arteries Circulation, March 28, 2000; 101(12): 1362 - 1365. [Abstract] [Full Text] [PDF]
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S. Patel, Y. Shi, R. Niculescu, E. H. Chung, J. L. Martin, and A. Zalewski Characteristics of Coronary Smooth Muscle Cells and Adventitial Fibroblasts Circulation, February 8, 2000; 101(5): 524 - 532. [Abstract] [Full Text] [PDF]
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Z.-Q. Zhao, M. Nakamura, N.-P. Wang, J. N. Wilcox, S. Shearer, R. S. Ronson, R. A. Guyton, and J. Vinten-Johansen Reperfusion induces myocardial apoptotic cell death Cardiovasc Res, February 1, 2000; 45(3): 651 - 660. [Abstract] [Full Text] [PDF]
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 B. H. Strauss and M. Rabinovitch Adventitial Fibroblasts . Defining a Role in Vessel Wall Remodeling Am. J. Respir. Cell Mol. Biol., January 1, 2000; 22(1): 1 - 3. [Full Text]
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E. Faggin, M. Puato, A. Chiavegato, R. Franch, P. Pauletto, and S. Sartore Fish Oil Supplementation Prevents Neointima Formation in Nonhypercholesterolemic Balloon-Injured Rabbit Carotid Artery by Reducing Medial and Adventitial Cell Activation Arterioscler Thromb Vasc Biol, January 1, 2000; 20(1): 152 - 163. [Abstract] [Full Text] [PDF]
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 X. Xin, N. Yang, and J. E. Faber Platelet-Derived Growth Factor-BB Inhibits Rat alpha 1D-Adrenergic Receptor Gene Expression in Vascular Smooth Muscle Cells by Inducing AP-2-Like Protein Binding to alpha 1D Proximal Promoter Region Mol. Pharmacol., December 1, 1999; 56(6): 1152 - 1161. [Abstract] [Full Text]
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 A. Okamura, M. Ohishi, H. Rakugi, T. Katsuya, Y. Yanagitani, S. Takiuchi, Y. Taniyama, K. Moriguchi, H. Ito, Y. Higashino, et al. Pharmacogenetic Analysis of the Effect of Angiotensin-Converting Enzyme Inhibitor on Restenosis After Percutaneous Transluminal Coronary Angioplasty Angiology, October 1, 1999; 50(10): 811 - 822. [Abstract] [PDF]
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D. D. Gutterman Adventitia-dependent influences on vascular function Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1265 - H1272. [Full Text] [PDF]
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C. Hehrlein, S. Kaiser, R. Riessen, J.u. Metz, P. Fritz, and W. Kubler External beam radiation after stent implantation increases neointimal hyperplasia by augmenting smooth muscle cell proliferation and extracellular matrix accumulation J. Am. Coll. Cardiol., August 1, 1999; 34(2): 561 - 566. [Abstract] [Full Text] [PDF]
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E. Faggin, M. Puato, L. Zardo, R. Franch, C. Millino, F. Sarinella, P. Pauletto, S. Sartore, and A. Chiavegato Smooth Muscle-Specific SM22 Protein Is Expressed in the Adventitial Cells of Balloon-Injured Rabbit Carotid Artery Arterioscler Thromb Vasc Biol, June 1, 1999; 19(6): 1393 - 1404. [Abstract] [Full Text] [PDF]
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 M. Ihara, H. Urata, A. Kinoshita, J. Suzumiya, M. Sasaguri, M. Kikuchi, M. Ideishi, and K. Arakawa Increased Chymase-Dependent Angiotensin II Formation in Human Atherosclerotic Aorta Hypertension, June 1, 1999; 33(6): 1399 - 1405. [Abstract] [Full Text] [PDF]
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Y. Shi, S. Patel, R. Niculescu, W. Chung, P. Desrochers, and A. Zalewski Role of Matrix Metalloproteinases and Their Tissue Inhibitors in the Regulation of Coronary Cell Migration Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1150 - 1155. [Abstract] [Full Text] [PDF]
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N. A. Giese, M. M. H. Marijianowski, O. McCook, A. Hancock, V. Ramakrishnan, L. J. Fretto, C. Chen, A. B. Kelly, J. A. Koziol, J. N. Wilcox, et al. The Role of Alpha and Beta Platelet-Derived Growth Factor Receptor in the Vascular Response to Injury in Nonhuman Primates Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 900 - 909. [Abstract] [Full Text] [PDF]
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I. J. Kullo, R. D. Simari, and R. S. Schwartz Vascular Gene Transfer : From Bench to Bedside Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 196 - 207. [Full Text] [PDF]
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M. R Bennett Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture Cardiovasc Res, February 1, 1999; 41(2): 361 - 368. [Abstract] [Full Text] [PDF]
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 J. Heckenkamp and G. M. Lamuraglia Intimal Hyperplasia, Arterial Remodeling, and Restenosis: An Overview Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 1999; 11(2): 71 - 94. [Abstract] [PDF]
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A. V. Tjurmin, N. M. Ananyeva, E. P. Smith, Y. Gao, M. K. Hong, M. B. Leon, and C. C. Haudenschild Studies on the Histogenesis of Myxomatous Tissue of Human Coronary Lesions Arterioscler Thromb Vasc Biol, January 1, 1999; 19(1): 83 - 97. [Abstract] [Full Text] [PDF]
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