(Circulation. 1996;93:1223-1229.)
© 1996 American Heart Association, Inc.
Articles |
Myocardial Contractile Response to Nitric Oxide and cGMP
From the Department of Physiology and Medicine, University of Antwerp, and the Cardiovascular Center (W.J.P.), O.L.V. Ziekenhuis, Aalst, Belgium.
Correspondence to Stanislas U. Sys, MD, PhD, Department of Physiology and Medicine, University of Antwerp (RUCA), Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
Background Cardiac endothelium releases a number of factors that may modulate performance of underlying cardiac muscle. Nitric oxide (NO), which accounts for the biological activity of the vascular endothelium-derived relaxing factor and relaxes vascular smooth muscle by elevating intracellular cGMP, may be involved in this cardiac modulation.
Methods and Results We examined the myocardial contractile effects of the NO-releasing nitrovasodilators sodium nitroprusside (SNP), 3-morpholino-sydnonimine (SIN-1), and S-nitroso-N-acetyl-penicillamine (SNAP); of a cGMP analogue, 8-bromo-cGMP; and of the cGMP-phosphodiesterase inhibitor zaprinast in isolated cat papillary muscle. Modulation of these effects by endocardial endothelium (EE) and by cholinergic and adrenergic stimulation was also investigated. Concentration-response curves with addition of NO-releasing nitrovasodilators (SNP, SIN-1, SNAP) and 8-bromo-cGMP resulted in a biphasic inotropic response. Although administration of low concentrations induced a positive inotropic effect, higher concentrations induced a negative inotropic effect. Both NO-induced positive and negative inotropic effects were attenuated by methylene blue, suggesting a role for cGMP. The response to high concentrations of 8-bromo-cGMP was shifted to the right in muscles with damaged EE, whereas cholinergic stimulation shifted the curve leftward. Zaprinast caused a monophasic concentration-dependent positive inotropic effect; damaging the EE shifted the terminal portion of the curve upward. Concomitant cholinergic or adrenergic stimulation modified the response to zaprinast into a negative inotropic response.
Conclusions NO and cGMP induced a concentration-dependent biphasic contractile response. The myocardial contractile effects of NO and cGMP were modulated by the status of EE and by concomitant cholinergic or adrenergic stimulation.
Key Words: nitric oxide • myocardium • contractility • endothelium • endocardium
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|
|
|
|
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|
|
|
|
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|
|
|
|
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|
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|
|
|
|
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|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
W. J Paulus and A. M Shah NO and cardiac diastolic function Cardiovasc Res, August 15, 1999; 43(3): 595 - 606. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
C. S Hayward, R. P Kelly, and P. S Macdonald Inhaled nitric oxide in cardiology practice Cardiovasc Res, August 15, 1999; 43(3): 628 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
G. Kojda and K. Kottenberg Regulation of basal myocardial function by NO Cardiovasc Res, March 1, 1999; 41(3): 514 - 523. [Full Text] [PDF]
|
|
|
|
|
|
G. Alloatti, C. Penna, A. De Martino, G. Montrucchio, and G. Camussi Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-{alpha} in the guinea-pig papillary muscle Cardiovasc Res, March 1, 1999; 41(3): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Ing, J. Zang, V. J. Dzau, K. A. Webster, and N. H. Bishopric Modulation of Cytokine-Induced Cardiac Myocyte Apoptosis by Nitric Oxide, Bak, and Bcl-x Circ. Res., January 22, 1999; 84(1): 21 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Recchia, P. I. McConnell, R. D. Bernstein, T. R. Vogel, X. Xu, and T. H. Hintze Reduced Nitric Oxide Production and Altered Myocardial Metabolism During the Decompensation of Pacing-Induced Heart Failure in the Conscious Dog Circ. Res., November 16, 1998; 83(10): 969 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
D. L. Brutsaert, P. Fransen, L. J. Andries, G. W. De Keulenaer, and S. U. Sys Cardiac endothelium and myocardial function Cardiovasc Res, May 1, 1998; 38(2): 281 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A De Mulder, S. G De Hert, R. J Van Kerckhoven, H. F Adriaensen, and T. C Gillebert Sodium nitroprusside enhances in vivo left ventricular function in {beta}-adrenergically stimulated rabbit hearts Cardiovasc Res, April 1, 1998; 38(1): 133 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
L. J. Andries, D. L. Brutsaert, and S. U. Sys Nonuniformity of Endothelial Constitutive Nitric Oxide Synthase Distribution in Cardiac Endothelium Circ. Res., February 9, 1998; 82(2): 195 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
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|
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|
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P. Beaulieu, R. Cardinal, P. Page, F. Francoeur, J. Tremblay, and C. Lambert Positive chronotropic and inotropic effects of C-type natriuretic peptide in dogs Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1933 - H1940. [Abstract] [Full Text] [PDF]
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 N. Abi-Gerges, T. Eschenhagen, L. Hove-Madsen, R. Fischmeister, and P.-F. Mery Methylene Blue Is a Muscarinic Antagonist in Cardiac Myocytes Mol. Pharmacol., September 1, 1997; 52(3): 482 - 490. [Abstract] [Full Text]
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B. D. Prendergast, B M. Sci, V. F. Sagach, and A. M. Shah Basal Release of Nitric Oxide Augments the Frank-Starling Response in the Isolated Heart Circulation, August 19, 1997; 96(4): 1320 - 1329. [Abstract] [Full Text]
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M. Flesch, H. Kilter, B. Cremers, O. Lenz, M. Südkamp, F. Kuhn-Regnier, and M. Böhm J. Pharmacol. Exp. Ther., June 1, 1997; 281(3): 1340 - 1349. [Abstract] [Full Text]
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A. J. Sherman, C. A. Davis III, F. J. Klocke, K. R. Harris, G. Srinivasan, A. S. Yaacoub, D. A. Quinn, K. A. Ahlin, and J. J. Jang Blockade of Nitric Oxide Synthesis Reduces Myocardial Oxygen Consumption In Vivo Circulation, March 4, 1997; 95(5): 1328 - 1334. [Abstract] [Full Text]
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J. Bartunek, A. M. Shah, M. Vanderheyden, and W. J. Paulus Dobutamine Enhances Cardiodepressant Effects of Receptor-Mediated Coronary Endothelial Stimulation Circulation, January 7, 1997; 95(1): 90 - 96. [Abstract] [Full Text]
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R. A. Kelly, J.-L. Balligand, and T. W. Smith Nitric Oxide and Cardiac Function Circ. Res., September 1, 1996; 79(3): 363 - 380. [Full Text]
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R. R. Lamberts, M. H. P. van Rijen, P. Sipkema, P. Fransen, S. U. Sys, and N. Westerhof Increased coronary perfusion augments cardiac contractility in the rat through stretch-activated ion channels Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1334 - H1340. [Abstract] [Full Text] [PDF]
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J. Layland, J.-M. Li, and A. M. Shah Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes J. Physiol., February 22, 2002; (2002) 200101412. [Abstract] [PDF]
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H.-J. Cheng, Z.-S. Zhang, K. Onishi, T. Ukai, D. C. Sane, and C.-P. Cheng Upregulation of Functional {beta}3-Adrenergic Receptor in the Failing Canine Myocardium Circ. Res., September 28, 2001; 89(7): 599 - 606. [Abstract] [Full Text] [PDF]
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G. U. Ahmmed, Y. Xu, P. Hong Dong, Z. Zhang, J. Eiserich, and N. Chiamvimonvat Nitric Oxide Modulates Cardiac Na+ Channel via Protein Kinase A and Protein Kinase G Circ. Res., November 23, 2001; 89(11): 1005 - 1013. [Abstract] [Full Text] [PDF]
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F. Brunner, P. Andrew, G. Wolkart, R. Zechner, and B. Mayer Myocardial Contractile Function and Heart Rate in Mice With Myocyte-Specific Overexpression of Endothelial Nitric Oxide Synthase Circulation, December 18, 2001; 104(25): 3097 - 3102. [Abstract] [Full Text] [PDF]
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