(Circulation. 1996;94:1125-1130.)
© 1996 American Heart Association, Inc.
Articles |
Percutaneous Multielectrode Endocardial Mapping During Ventricular Tachycardia in the Swine Model
the Neufeld Cardiac Research Institute, Tel Aviv University, Israel (M.E., D.O., Z.V., Z.R.); the Department of Medicine, University of California, San Francisco (A.P.F., M.C., M.M.S., M.D.L.); the Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, Pa (M.F.S., S.H., A.J.G.); and EP Technologies, Sunnyvale, Calif (J.G.W., T.K., D.K.S.).
Correspondence to Michael Eldar, MD, Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel.
Background Identification of critical areas within the ventricular tachycardia circuit is a prerequisite for catheter ablation. Currently, mapping during ventricular tachycardia, usually performed with standard catheters, is difficult and time-consuming and can be used only in patients with hemodynamically stable tachycardia.
Methods and Results A total of 43 pigs underwent closed-chest induction of myocardial infarction. A basket-shaped catheter carrying 64 electrodes was deployed in the left ventricle during normal sinus rhythm. Unipolar pacing at 3 mA was successful in 78% of the basket catheter electrodes, demonstrating good electrode-tissue contact. Hemodynamic and echocardiographic measurements did not reveal any significant interference with myocardial or valvular function during or after catheter deployment. One hundred eighteen episodes of monomorphic ventricular tachycardia were induced in 28 pigs through right ventricular stimulation, 81 of which were mapped and analyzed. Ventricular tachycardia mapping was rapid, requiring only several beats and <10 seconds to complete. Presystolic potentials, a possible target for ablation, were identified in 58% of the tachycardia episodes mapped. Pathological examination revealed only minor valvular and endocardial catheter–induced lesions immediately after mapping and none a month later.
Conclusions The multielectrode catheter enables rapid and safe percutaneous endocardial mapping of ventricular tachycardia in the swine model. Exploration of the clinical potential of the multielectrode catheter seems warranted.
Key Words: mapping • tachycardia • catheter
This article has been cited by other articles:
 |
|
 |
|
  T. H. Everett IV, E. E. Wilson, S. Foreman, and J. E. Olgin Mechanisms of Ventricular Fibrillation in Canine Models of Congestive Heart Failure and Ischemia Assessed by In Vivo Noncontact Mapping Circulation, September 13, 2005; 112(11): 1532 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Y. Reddy, D. Wrobleski, C. Houghtaling, M. E. Josephson, and J. N. Ruskin Combined Epicardial and Endocardial Electroanatomic Mapping in a Porcine Model of Healed Myocardial Infarction Circulation, July 1, 2003; 107(25): 3236 - 3242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Burnes, B. Taccardi, and Y. Rudy A Noninvasive Imaging Modality for Cardiac Arrhythmias Circulation, October 24, 2000; 102(17): 2152 - 2158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zrenner, G. Ndrepepa, M. Schneider, M. Karch, F. Hofmann, A. Schomig, and C. Schmitt Computer-assisted animation of atrial tachyarrhythmias recorded with a 64-electrode basket catheter J. Am. Coll. Cardiol., December 1, 1999; 34(7): 2051 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Callans, J.-F. Ren, J. Michele, F. E. Marchlinski, and S. M. Dillon Electroanatomic Left Ventricular Mapping in the Porcine Model of Healed Anterior Myocardial Infarction : Correlation With Intracardiac Echocardiography and Pathological Analysis Circulation, October 19, 1999; 100(16): 1744 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sun, E. O. Velipasaoglu, D. E. Wu, H. A. Kopelen, W. A. Zoghbi, W. H. Spencer III, and D. S. Khoury Simultaneous Multisite Mapping of the Right and the Left Atrial Septum in the Canine Intact Beating Heart Circulation, July 20, 1999; 100(3): 312 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schmitt, B. Zrenner, M. Schneider, M. Karch, G. Ndrepepa, I. Deisenhofer, S. Weyerbrock, J. Schreieck, and A. Schomig Clinical Experience With a Novel Multielectrode Basket Catheter in Right Atrial Tachycardias Circulation, May 11, 1999; 99(18): 2414 - 2422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kadish, J. Hauck, B. Pederson, G. Beatty, and C. Gornick Mapping of Atrial Activation With a Noncontact, Multielectrode Catheter in Dogs Circulation, April 13, 1999; 99(14): 1906 - 1913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Gornick, S. W. Adler, B. Pederson, J. Hauck, J. Budd, and J. Schweitzer Validation of a New Noncontact Catheter System for Electroanatomic Mapping of Left Ventricular Endocardium Circulation, February 16, 1999; 99(6): 829 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. R. M. Smeets, S. A. Ben-Haim, L.-M. Rodriguez, C. Timmermans, and H. J. J. Wellens New Method for Nonfluoroscopic Endocardial Mapping in Humans : Accuracy Assessment and First Clinical Results Circulation, June 23, 1998; 97(24): 2426 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nitta, R. B. Schuessler, M. Mitsuno, C. K. Rokkas, F. Isobe, C. S. Cronin, J. L. Cox, and J. P. Boineau Return Cycle Mapping After Entrainment of Ventricular Tachycardia Circulation, March 31, 1998; 97(12): 1164 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Khoury, K. L. Berrier, S. M. Badruddin, and W. A. Zoghbi Three-Dimensional Electrophysiological Imaging of the Intact Canine Left Ventricle Using a Noncontact Multielectrode Cavitary Probe: Study of Sinus, Paced, and Spontaneous Premature Beats Circulation, February 3, 1998; 97(4): 399 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Eldar, D. G. Ohad, J. J. Goldberger, Z. Rotstein, S. Hsu, D. K. Swanson, and A. J. Greenspon Transcutaneous Multielectrode Basket Catheter for Endocardial Mapping and Ablation of Ventricular Tachycardia in the Pig Circulation, October 7, 1997; 96(7): 2430 - 2437. [Abstract] [Full Text]
|
|