(Circulation. 1996;94:992-1002.)
© 1996 American Heart Association, Inc.
Articles |
Evidence for Functional Relevance of an Enhanced Expression of the Na+-Ca2+ Exchanger in Failing Human Myocardium
Klinik III fur Innere Medizin (M.F., R.H.G.S., F.S., K.F., M.B.), Klinik fur Herz und Gefaßchirurgie (M.S., F.K.-R.), and Institut fur Pathologie der Universitat zu Koln (G.A.), Koln, Germany.
Correspondence to Prof Dr med M. Bohm, Klinik III fur Innere Medizin der Universitat zu Koln, Joseph Stelzmann Str 9, 50924 Koln, FRG.
Background The present study aimed at investigating the expression of the Na+-Ca2+ exchanger and its functional role in human failing myocardium.
Methods and Results Na+-Ca2+ exchanger mRNA and protein levels were examined in nonfailing (NF, n=8) and failing human myocardium (New York Heart Association functional class IV) with idiopathic dilated cardiomyopathy (DCM, n=8) or ischemic heart disease (ICM, n=6). The inotropic effect of the Na+ channel activator BDF 9148 was determined in electrically driven left ventricular papillary muscle strip preparations (1 Hz, 37°C) from nonfailing (n=8) and failing (n=8) human hearts. Na+-Ca2+ exchanger mRNA levels were significantly increased, by 79% (P<.001) in DCM and by 58% (P<.01) in ICM compared with NF; protein levels increased by 36% (P<.001) and by 20% (P<.05), respectively. BDF 9148 increased the force of contraction concentration dependently, with a similar maximal effect in NYHA class IV and NF, but was more potent in NYHA class IV as demonstrated by a significantly smaller (P<.01) EC50 value (NYHA class IV, 0.18 [0.16 to 0.22] µmol/L; NF, 1.65 [1.3 to 3.0] µmol/L). In NYHA class IV, BDF 9148 (0.1 µmol/L) restored the positive force-frequency relationship and reduced the frequency-dependent increase in diastolic tension in relation to force of contraction.
Conclusions The increased expression of the Na+-Ca2+ exchanger is a possible explanation for the increased inotropic potency of the Na+ channel activator BDF 9148 in failing human myocardium. The increase in exchanger molecules could be of functional relevance for the modulation of cardiac contractility by agents that increase the intracellular Na+ concentration. Enhancement of Na+-Ca2+ exchanger activity might be a powerful mechanism for increasing cardiac contractility in chronic heart failure.
Key Words: heart failure • calcium channels • inotropic agents • sodium • excitation
This article has been cited by other articles:
 |
|
 |
|
  P. Stewart, O. V. Aslanidi, D. Noble, P. J. Noble, M. R. Boyett, and H. Zhang Mathematical models of the electrical action potential of Purkinje fibre cells Phil Trans R Soc A, June 13, 2009; 367(1896): 2225 - 2255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. G. Daniels, T. Naya, V. L. M. Rundell, and P. P. de Tombe Development of contractile dysfunction in rat heart failure: hierarchy of cellular events Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R284 - R292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Leszek, M. Szperl, A. Klisiewicz, J. Janas, A. Biederman, T. Rywik, W. Piotrowski, M. Kopacz, and J. Korewicki Alteration of myocardial sarcoplasmic reticulum Ca2+-ATPase and Na+-Ca2+ exchanger expression in human left ventricular volume overload Eur J Heart Fail, June 1, 2007; 9(6-7): 579 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nattel, A. Maguy, S. Le Bouter, and Y.-H. Yeh Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation Physiol Rev, April 1, 2007; 87(2): 425 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Ander, C. Hurtado, C. S. Raposo, T. G. Maddaford, J. F. Deniset, L. V. Hryshko, G. N. Pierce, and A. Lukas Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to {alpha}-linolenic acid Cardiovasc Res, January 15, 2007; 73(2): 395 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Munch, K. Rosport, C. Baumgartner, Z. Li, S. Wagner, A. Bultmann, and M. Ungerer Functional alterations after cardiac sodium-calcium exchanger overexpression in heart failure Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H488 - H495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Reuter, C. Pott, J. I. Goldhaber, S. A. Henderson, K. D. Philipson, and R. H.G. Schwinger Na+-Ca2+exchange in the regulation of cardiac excitation-contraction coupling Cardiovasc Res, August 1, 2005; 67(2): 198 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Shao, B. Ren, V. Elimban, P. S. Tappia, N. Takeda, and N. S. Dhalla Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2637 - H2646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Shen, R. M. Gill, J.-P. Zhang, B. D. Jones, A. K. Corbly, and M. I. Steinberg Sodium channel enhancer restores baroreflex sensitivity in conscious dogs with heart failure Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1508 - H1514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bolck, G. Munch, P. Mackenstein, M. Hellmich, I. Hirsch, H. Reuter, N. Hattebuhr, H.-J. Weig, M. Ungerer, K. Brixius, et al. Na+/Ca2+ exchanger overexpression impairs frequency- and ouabain-dependent cell shortening in adult rat cardiomyocytes Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1435 - H1445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wasson, H. K. Reddy, and M. L. Dohrmann Current Perspectives of Electrical Remodeling and Its Therapeutic Implications Journal of Cardiovascular Pharmacology and Therapeutics, April 1, 2004; 9(2): 129 - 144. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Kogler, O. Hartmann, K. Leineweber, P. Nguyen van, P. Schott, O.-E. Brodde, and G. Hasenfuss Mechanical Load-Dependent Regulation of Gene Expression in Monocrotaline-Induced Right Ventricular Hypertrophy in the Rat Circ. Res., August 8, 2003; 93(3): 230 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Armoundas, I. A. Hobai, G. F. Tomaselli, R. L. Winslow, and B. O'Rourke Role of Sodium-Calcium Exchanger in Modulating the Action Potential of Ventricular Myocytes From Normal and Failing Hearts Circ. Res., July 11, 2003; 93(1): 46 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Schillinger, J. W Fiolet, K. Schlotthauer, and G. Hasenfuss Relevance of Na+-Ca2+ exchange in heart failure Cardiovasc Res, March 15, 2003; 57(4): 921 - 933. [Full Text] [PDF]
|
|
|
|
|
|
J. Weisser-Thomas, V. Piacentino III, J. P Gaughan, K. Margulies, and S. R Houser Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes Cardiovasc Res, March 15, 2003; 57(4): 974 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W Schillinger, A Ohler, S Emami, F Muller, C Christians, P.M.L Janssen, H Kogler, N Teucher, B Pieske, T Seidler, et al. The functional effect of adenoviral Na+/Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+-ATPase Cardiovasc Res, March 15, 2003; 57(4): 996 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sah, R. J Ramirez, G. Y Oudit, D. Gidrewicz, M. G Trivieri, C. Zobel, and P. H Backx Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito) J. Physiol., January 1, 2003; 546(1): 5 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Micheletti, G. G. Mattera, M. Rocchetti, A. Schiavone, M. F. Loi, A. Zaza, R. J. P. Gagnol, S. De Munari, P. Melloni, P. Carminati, et al. Pharmacological Profile of the Novel Inotropic Agent (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride (PST2744) J. Pharmacol. Exp. Ther., November 1, 2002; 303(2): 592 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Shen, R. M. Gill, B. D. Jones, J.-P. Zhang, A. K. Corbly, and M. I. Steinberg Combined Inotropic and Bradycardic Effects of a Sodium Channel Enhancer in Conscious Dogs with Heart Failure: A Mechanism for Improved Myocardial Efficiency Compared with Dobutamine J. Pharmacol. Exp. Ther., November 1, 2002; 303(2): 673 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Gomez, B. Schwaller, H. Porzig, G. Vassort, E. Niggli, and M. Egger Increased Exchange Current but Normal Ca2+ Transport via Na+-Ca2+ Exchange During Cardiac Hypertrophy After Myocardial Infarction Circ. Res., August 23, 2002; 91(4): 323 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Schillinger, H. Schneider, K. Minami, R. Ferrari, and G. Hasenfuss Importance of sympathetic activation for the expression of Na+-Ca2+ exchanger in end-stage failing human myocardium Eur. Heart J., July 2, 2002; 23(14): 1118 - 1124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kneller, H. Sun, N. Leblanc, and S. Nattel Remodeling of Ca2+-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation Cardiovasc Res, May 1, 2002; 54(2): 416 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Alpert, L. A. Mulieri, and D. Warshaw The failing human heart Cardiovasc Res, April 1, 2002; 54(1): 1 - 10. [Full Text] [PDF]
|
|
|
|
|
|
K. R Sipido, P. G.A Volders, M. A Vos, and F. Verdonck Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc Res, March 1, 2002; 53(4): 782 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sugishita, Z. Su, F. Li, K. D. Philipson, and W. H. Barry Gender Influences [Ca2+]i During Metabolic Inhibition in Myocytes Overexpressing the Na+-Ca2+ Exchanger Circulation, October 23, 2001; 104(17): 2101 - 2106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Elias, A. Lukas, S. Shurraw, J. Scott, A. Omelchenko, G. J. Gross, M. Hnatowich, and L. V. Hryshko Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1334 - H1345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J Conway and S. V Koushik Cardiac sodium-calcium exchanger: a double-edged sword Cardiovasc Res, August 1, 2001; 51(2): 194 - 197. [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Boateng, R. U. Naqvi, M. U. Koban, M. H. Yacoub, K. T. MacLeod, and K. R. Boheler Low-dose ramipril treatment improves relaxation and calcium cycling after established cardiac hypertrophy Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1029 - H1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Woo and M. Morad Bimodal regulation of Na+-Ca2+ exchanger by beta -adrenergic signaling pathway in shark ventricular myocytes PNAS, February 1, 2001; (2001) 41327398. [Abstract] [Full Text]
|
|
|
|
|
|
T. G. Hampton, J.-F. Wang, J. DeAngelis, I. Amende, K. D. Philipson, and J. P. Morgan Enhanced gene expression of Na+/Ca2+ exchanger attenuates ischemic and hypoxic contractile dysfunction Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2846 - H2854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Heerdt, J. W. Holmes, B. Cai, A. Barbone, J. D. Madigan, S. Reiken, D. L. Lee, M. C. Oz, A. R. Marks, and D. Burkhoff Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure Circulation, November 28, 2000; 102(22): 2713 - 2719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Greenstein, R. Wu, S. Po, G. F. Tomaselli, and R. L. Winslow Role of the Calcium-Independent Transient Outward Current Ito1 in Shaping Action Potential Morphology and Duration Circ. Res., November 24, 2000; 87(11): 1026 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Satoh, T. M. Suter, R. Liao, and W. S. Colucci Chronic {alpha}-Adrenergic Receptor Stimulation Modulates the Contractile Phenotype of Cardiac Myocytes In Vitro Circulation, October 31, 2000; 102(18): 2249 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Sipido, P. G. A. Volders, S. H. M. de Groot, F. Verdonck, F. Van de Werf, H. J. J. Wellens, and M. A. Vos Enhanced Ca2+ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes : Potential Link Between Contractile Adaptation and Arrhythmogenesis Circulation, October 24, 2000; 102(17): 2137 - 2144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Pogwizd Increased Na+-Ca2+ Exchanger in the Failing Heart Circ. Res., October 13, 2000; 87(8): 641 - 643. [Full Text] [PDF]
|
|
|
|
|
|
I. A. Hobai and B. O'Rourke Enhanced Ca2+-Activated Na+-Ca2+ Exchange Activity in Canine Pacing-Induced Heart Failure Circ. Res., October 13, 2000; 87(8): 690 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Barry Na+-Ca2+ Exchange in Failing Myocardium : Friend or Foe? Circ. Res., September 29, 2000; 87(7): 529 - 531. [Full Text] [PDF]
|
|
|
|
|
|
W. Schillinger, P. M. L. Janssen, S. Emami, S. A. Henderson, R. S. Ross, N. Teucher, O. Zeitz, K. D. Philipson, J. Prestle, and G. Hasenfuss Impaired Contractile Performance of Cultured Rabbit Ventricular Myocytes After Adenoviral Gene Transfer of Na+-Ca2+ Exchanger Circ. Res., September 29, 2000; 87(7): 581 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Bers Calcium Fluxes Involved in Control of Cardiac Myocyte Contraction Circ. Res., August 18, 2000; 87(4): 275 - 281. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Piper, J. Bilger, E.-M. Henrichs, H.-P. Schultheiss, D. Horstkotte, and A. Doerner Is myocardial Na+/Ca2+ exchanger transcription a marker for different stages of myocardial dysfunction? Quantitative polymerase chain reaction of the messenger RNA in endomyocardial biopsies of patients with heart failure J. Am. Coll. Cardiol., July 1, 2000; 36(1): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mitarai, T. D. Reed, and A. Yatani Changes in ionic currents and beta -adrenergic receptor signaling in hypertrophied myocytes overexpressing Galpha q Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H139 - H148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Brooks, O. H. L. Bing, M. O. Boluyt, A. Malhotra, J. P. Morgan, N. Satoh, W. S. Colucci, and C. H. Conrad Altered Inotropic Responsiveness and Gene Expression of Hypertrophied Myocardium With Captopril Hypertension, June 1, 2000; 35(6): 1203 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. U. Ahmmed, P. H. Dong, G. Song, N. A. Ball, Y. Xu, R. A. Walsh, and N. Chiamvimonvat Changes in Ca2+ Cycling Proteins Underlie Cardiac Action Potential Prolongation in a Pressure-Overloaded Guinea Pig Model With Cardiac Hypertrophy and Failure Circ. Res., March 17, 2000; 86(5): 558 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S Maier, C. Schwan, W. Schillinger, K. Minami, U. Schutt, and B. Pieske Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium Cardiovasc Res, March 1, 2000; 45(4): 913 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G Matteo and C. S. Moravec Immunolocalization of annexins IV, V and VI in the failing and non-failing human heart Cardiovasc Res, March 1, 2000; 45(4): 961 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Walker, F. A. Crawford Jr, and F. G. Spinale MYOCYTE CONTRACTILE DYSFUNCTION WITH HYPERTROPHY AND FAILURE: RELEVANCE TO CARDIAC SURGERY J. Thorac. Cardiovasc. Surg., February 1, 2000; 119(2): 388 - 400. [Full Text] [PDF]
|
|
|
|
|
|
S. M. Pogwizd, M. Qi, W. Yuan, A. M. Samarel, and D. M. Bers Upregulation of Na+/Ca2+ Exchanger Expression and Function in an Arrhythmogenic Rabbit Model of Heart Failure Circ. Res., November 26, 1999; 85(11): 1009 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Prestle, S. Dieterich, M. Preuss, U. Bieligk, and G. Hasenfuss Heterogeneous transmural gene expression of calcium-handling proteins and natriuretic peptides in the failing human heart Cardiovasc Res, August 1, 1999; 43(2): 323 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Flesch, C. Maack, B. Cremers, A. T. Baumer, M. Sudkamp, and M. Bohm Effect of {beta}-Blockers on Free Radical–Induced Cardiac Contractile Dysfunction Circulation, July 27, 1999; 100(4): 346 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pieske, L. S. Maier, D. M. Bers, and G. Hasenfuss Ca2+ Handling and Sarcoplasmic Reticulum Ca2+ Content in Isolated Failing and Nonfailing Human Myocardium Circ. Res., July 9, 1999; 85(1): 38 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Weinberg, C. D. Thienelt, S. E. Katz, J. Bartunek, M. Tajima, S. Rohrbach, P. S. Douglas, and B. H. Lorell Gender differences in molecular remodeling in pressure overload hypertrophy J. Am. Coll. Cardiol., July 1, 1999; 34(1): 264 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Blaustein and W. J. Lederer Sodium/Calcium Exchange: Its Physiological Implications Physiol Rev, July 1, 1999; 79(3): 763 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Nuss, S. Kaab, D. A. Kass, G. F. Tomaselli, and E. Marban Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H80 - H91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sethi, K. S. Dhalla, P. K. Ganguly, R. Ferrari, and N. S. Dhalla Beneficial effects of propionyl L-carnitine on sarcolemmal changes in congestive heart failure due to myocardial infarction Cardiovasc Res, June 1, 1999; 42(3): 607 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Owen, P. B. J. Burton, M. C. Michel, O. Zolk, M. Bohm, J. R. Pepper, P. J. R. Barton, M. H. Yacoub, and S. E. Harding Myocardial Dysfunction in Donor Hearts : A Possible Etiology Circulation, May 18, 1999; 99(19): 2565 - 2570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Tomaselli and E. Marban Electrophysiological remodeling in hypertrophy and heart failure Cardiovasc Res, May 1, 1999; 42(2): 270 - 283. [Full Text] [PDF]
|
|
|
|
|
|
R. H. G. Schwinger, J. Wang, K. Frank, J. Muller-Ehmsen, K. Brixius, A. A. McDonough, and E. Erdmann Reduced Sodium Pump {{alpha}}1, {{alpha}}3, and ß1-Isoform Protein Levels and Na+,K+-ATPase Activity but Unchanged Na+-Ca2+ Exchanger Protein Levels in Human Heart Failure Circulation, April 27, 1999; 99(16): 2105 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. O'Rourke, D. A. Kass, G. F. Tomaselli, S. Kaab, R. Tunin, and E. Marban Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, I : Experimental Studies Circ. Res., March 19, 1999; 84(5): 562 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Winslow, J. Rice, S. Jafri, E. Marban, and B. O'Rourke Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II : Model Studies Circ. Res., March 19, 1999; 84(5): 571 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss, W. Schillinger, S. E. Lehnart, M. Preuss, B. Pieske, L. S. Maier, J. Prestle, K. Minami, and H. Just Relationship Between Na+-Ca2+–Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium Circulation, February 9, 1999; 99(5): 641 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yao, Z. Su, A. Nonaka, I. Zubair, K. W. Spitzer, J. H. B. Bridge, G. Muelheims, J. Ross Jr., and W. H. Barry Abnormal myocyte Ca2+ homeostasis in rabbits with pacing-induced heart failure Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1441 - H1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Mittmann, T Eschenhagen, and H Scholz Cellular and molecular aspects of contractile dysfunction in heart failure Cardiovasc Res, August 1, 1998; 39(2): 267 - 275. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. M. Shuba, T. Iwata, V. G. Naidenov, M. Oz, K. Sandberg, A. Kraev, E. Carafoli, and M. Morad A Novel Molecular Determinant for cAMP-dependent Regulation of the Frog Heart Na+-Ca2+ Exchanger J. Biol. Chem., July 24, 1998; 273(30): 18819 - 18825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cernohorsky, V. Pelouch, B. Korecky, and R. Vetter Thyroid control of sarcolemmal Na+/Ca2+ exchanger and SR Ca2+-ATPase in developing rat heart Am J Physiol Heart Circ Physiol, July 1, 1998; 275(1): H264 - H273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Priebe and D. J. Beuckelmann Simulation Study of Cellular Electric Properties in Heart Failure Circ. Res., June 15, 1998; 82(11): 1206 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. McCall, K. S. Ginsburg, R. A. Bassani, T. R. Shannon, M. Qi, A. M. Samarel, and D. M. Bers Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1348 - H1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss Alterations of calcium-regulatory proteins in heart failure Cardiovasc Res, February 1, 1998; 37(2): 279 - 289. [Full Text] [PDF]
|
|
|
|
|
|
A. D Wickenden, R. Kaprielian, Z. Kassiri, J. N Tsoporis, R. Tsushima, G. I Fishman, and P. H Backx The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure Cardiovasc Res, February 1, 1998; 37(2): 312 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P de Tombe Altered contractile function in heart failure Cardiovasc Res, February 1, 1998; 37(2): 367 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Handrock, F. Schroder, S. Hirt, A. Haverich, C. Mittmann, and S. Herzig Single-channel properties of L-type calcium channels from failing human ventricle Cardiovasc Res, February 1, 1998; 37(2): 445 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R Sipido, T. Stankovicova, W. Flameng, J. Vanhaecke, and F. Verdonck Frequency dependence of Ca2+ release from the sarcoplasmic reticulum in human ventricular myocytes from end-stage heart failure Cardiovasc Res, February 1, 1998; 37(2): 478 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R.W. Money-Kyrle, C. H. Davies, H. K. Ranu, P. O'Gara, N. Singh Kent, P. A. Poole-Wilson, and S. E. Harding The role of cAMP in the frequency-dependent changes in contraction of guinea-pig cardiomyocytes Cardiovasc Res, February 1, 1998; 37(2): 532 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Nicholas, W. Yang, S.-L. Lee, H. Zhu, K. D. Philipson, and J. Lytton Alternative promoters and cardiac muscle cell-specific expression of the Na+/Ca2+ exchanger gene Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H217 - H232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Sipido, M. Maes, and F. Van de Werf Low Efficiency of Ca2+ Entry Through the Na+-Ca2+ Exchanger as Trigger for Ca2+ Release From the Sarcoplasmic Reticulum : A Comparison Between L-Type Ca2+ Current and Reverse-Mode Na+-Ca2+ Exchange Circ. Res., December 19, 1997; 81(6): 1034 - 1044. [Abstract] [Full Text]
|
|
|
|
|
|
S. E. Litwin and J. H. B. Bridge Enhanced Na+-Ca2+ Exchange in the Infarcted Heart : Implications for Excitation-Contraction Coupling Circ. Res., December 19, 1997; 81(6): 1083 - 1093. [Abstract] [Full Text]
|
|
|
|
|
|
R. H. G. Schwinger, K. Brixius, U. Bavendiek, S. Hoischen, J. Müller-Ehmsen, B. Bölck, and E. Erdmann Effect of Cyclopiazonic Acid on the Force-Frequency Relationship in Human Nonfailing Myocardium J. Pharmacol. Exp. Ther., October 1, 1997; 283(1): 286 - 292. [Abstract] [Full Text]
|
|
|
|
|
|
C. E. Zaugg, S. T. Wu, R. J. Lee, J. Wikman-Coffelt, and W. W. Parmley Intracellular Ca2+ Handling and Vulnerability to Ventricular Fibrillation in Spontaneously Hypertensive Rats Hypertension, September 1, 1997; 30(3): 461 - 467. [Abstract] [Full Text]
|
|
|
|
|
|
Z. Wang, B. Nolan, W. Kutschke, and J. A. Hill Na+-Ca2+ Exchanger Remodeling in Pressure Overload Cardiac Hypertrophy J. Biol. Chem., May 18, 2001; 276(21): 17706 - 17711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Woo and M. Morad Bimodal regulation of Na+-Ca2+ exchanger by beta -adrenergic signaling pathway in shark ventricular myocytes PNAS, February 13, 2001; 98(4): 2023 - 2028. [Abstract] [Full Text] [PDF]
|
|