(Circulation. 1997;95:320-323.)
© 1997 American Heart Association, Inc.
Articles |
Apoptosis in Human Acute Myocardial Infarction
the Departments of Anatomy (A.S., K.H., M.P.), Clinical Chemistry (K.P.), Pathology (M.K.), and Medicine (A.S., L.-M.V.-P.), University of Turku, Kiinamyllynkatu 4-8, Finland.
Correspondence to Liisa-Maria Voipio-Pulkki, MD, Department of Medicine, University of Turku, FIN-20520 Turku, Finland. E-mail liisa-maria.voipio-pulkki{at}utu.fi
Background After reopening of the infarct-related coronary artery, cardiomyocytes continue to die during reperfusion. The mechanisms of cell death have been subject to debate. We studied whether an apoptotic type of cell death occurs in human acute myocardial infarction (AMI).
Methods and Results We studied myocardial samples of eight patients who died of AMI and had patent infarct-related arteries at autopsy. Six of the patients had received initially successful thrombolysis. Extensive formation of DNA strand breaks, the typical biochemical feature of apoptosis, was detected with the use of the in situ DNA end-labeling method. Apoptotic cardiomyocytes were observed particularly in the border zones of histologically infarcted myocardium, whereas very few apoptotic cells were present in the remote noninfarcted myocardium. Internucleosomal fragmentation was confirmed by agarose gel electrophoresis of DNA isolated from the representative myocardial areas.
Conclusions This study provides evidence that in addition to overt necrosis, a subset of myocytes undergo apoptosis during ischemia-reperfusion injury. Apoptosis may provide a new target for cardioprotection during evolving AMI in humans.
Key Words: apoptosis • myocardial infarction • reperfusion • ischemia • thrombolysis
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Y. Shizukuda and P. M. Buttrick Protein kinase C-zeta modulates thromboxane A2-mediated apoptosis in adult ventricular myocytes via Akt Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H320 - H327. [Abstract] [Full Text] [PDF]
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M. Leicht, W. Briest, A. Holzl, and H.-G. Zimmer Serum depletion induces cell loss of rat cardiac fibroblasts and increased expression of extracellular matrix proteins in surviving cells Cardiovasc Res, December 1, 2001; 52(3): 429 - 437. [Abstract] [Full Text] [PDF]
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 Z. Mallat, P. Fornes, R. Costagliola, B. Esposito, J. Belmin, D. Lecomte, and A. Tedgui Age and Gender Effects on Cardiomyocyte Apoptosis in the Normal Human Heart J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2001; 56(11): M719 - 723. [Abstract] [Full Text] [PDF]
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J. Shiraishi, T. Tatsumi, N. Keira, K. Akashi, A. Mano, S. Yamanaka, S. Matoba, J. Asayama, T. Yaoi, S. Fushiki, et al. Important role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1637 - H1647. [Abstract] [Full Text] [PDF]
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D Tousoulis, G J Davies, C Tentolouris, G Goumas, C Stefanadis, and P Toutouzas Vasomotor effects of L- and D-arginine in stenotic atheromatous coronary plaque Heart, September 1, 2001; 86(3): 296 - 301. [Abstract] [Full Text] [PDF]
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H. Liu, B. C. McPherson, and Z. Yao Preconditioning attenuates apoptosis and necrosis: role of protein kinase C{epsilon} and -{delta} isoforms Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H404 - H410. [Abstract] [Full Text] [PDF]
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E. Palojoki, A. Saraste, A. Eriksson, K. Pulkki, M. Kallajoki, L.-M. Voipio-Pulkki, and I. Tikkanen Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2726 - H2731. [Abstract] [Full Text] [PDF]
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M. Palmen, M.J.A.P. Daemen, R. Bronsaer, W.R.M. Dassen, H.R. Zandbergen, M. Kockx, J.F.M. Smits, R. van der Zee, and P.A. Doevendans Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice Cardiovasc Res, June 1, 2001; 50(3): 516 - 524. [Abstract] [Full Text] [PDF]
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 A. E Basile-Borgia and V. C Ware Life and death of a cardiac myocyte: principles of cellular biology Perfusion, May 1, 2001; 16(3): 229 - 241. [Abstract] [PDF]
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 G. D. Dispersyn and M. Borgers Apoptosis in the Heart: About Programmed Cell Death and Survival Physiology, February 1, 2001; 16(1): 41 - 47. [Abstract] [Full Text] [PDF]
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D Tousoulis, C Tentolouris, T Crake, G Goumas, C Stefanadis, P Toutouzas, and G Davies Complex stenosis morphology and vasomotor responses to inhibition of nitric oxide synthesis Heart, November 1, 2000; 84(5): 529 - 534. [Abstract] [Full Text]
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K. Yasui, K. Kada, M. Hojo, J.-K. Lee, K. Kamiya, J. Toyama, T. Opthof, and I. Kodama Cell-to-cell interaction prevents cell death in cultured neonatal rat ventricular myocytes Cardiovasc Res, October 1, 2000; 48(1): 68 - 76. [Abstract] [Full Text] [PDF]
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T. Imanishi, C. E. Murry, H. Reinecke, T. Hano, I. Nishio, W.C. Liles, L. Hofsta, K. Kim, K. D. O'Brien, S. M. Schwartz, et al. Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues Cardiovasc Res, October 1, 2000; 48(1): 101 - 110. [Abstract] [Full Text] [PDF]
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Myocardial Myocardial infarction redefined--A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction Eur. Heart J., September 2, 2000; 21(18): 1502 - 1513. [Abstract] [PDF]
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I. Jeremias, C. Kupatt, A. Martin-Villalba, H. Habazettl, J. Schenkel, P. Boekstegers, and K. M. Debatin Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia Circulation, August 22, 2000; 102(8): 915 - 920. [Abstract] [Full Text] [PDF]
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P. M. Kang and S. Izumo Apoptosis and Heart Failure : A Critical Review of the Literature Circ. Res., June 9, 2000; 86(11): 1107 - 1113. [Full Text] [PDF]
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N. Latif, M. A. Khan, E. Birks, A. O'Farrell, J. Westbrook, M. J. Dunn, and M. H. Yacoub Upregulation of the Bcl-2 family of proteins in end stage heart failure J. Am. Coll. Cardiol., June 1, 2000; 35(7): 1769 - 1777. [Abstract] [Full Text] [PDF]
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T. N. James Homage to James B. Herrick: A Contemporary Look at Myocardial Infarction and at Sickle-Cell Heart Disease : The 32nd Annual Herrick Lecture of the Council on Clinical Cardiology of the American Heart Association Circulation, April 18, 2000; 101(15): 1874 - 1887. [Full Text] [PDF]
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 O. J. Arola, A. Saraste, K. Pulkki, M. Kallajoki, M. Parvinen, and L.-M. Voipio-Pulkki Acute Doxorubicin Cardiotoxicity Involves Cardiomyocyte Apoptosis Cancer Res., April 1, 2000; 60(7): 1789 - 1792. [Abstract] [Full Text]
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H. Spitznagel, O. Chung, Q.-G. Xia, B. Rossius, S. Illner, G. Jahnichen, S. Sandmann, A. Reinecke, M. J.A.P. Daemen, and T. Unger Cardioprotective effects of the Na+/H+-exchange inhibitor cariporide in infarct-induced heart failure Cardiovasc Res, April 1, 2000; 46(1): 102 - 110. [Abstract] [Full Text] [PDF]
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J.-i. Abe, C. P. Baines, and B. C. Berk Role of Mitogen-Activated Protein Kinases in Ischemia and Reperfusion Injury : The Good and the Bad Circ. Res., March 31, 2000; 86(6): 607 - 609. [Full Text] [PDF]
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A. Haunstetter and S. Izumo Toward Antiapoptosis as a New Treatment Modality Circ. Res., March 3, 2000; 86(4): 371 - 376. [Full Text] [PDF]
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L. J. De Windt, H. W. Lim, T. Taigen, D. Wencker, G. Condorelli, G. W. Dorn II, R. N. Kitsis, and J. D. Molkentin Calcineurin-Mediated Hypertrophy Protects Cardiomyocytes From Apoptosis In Vitro and In Vivo : An Apoptosis-Independent Model of Dilated Heart Failure Circ. Res., February 18, 2000; 86(3): 255 - 263. [Abstract] [Full Text] [PDF]
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A. Saraste and K. Pulkki Morphologic and biochemical hallmarks of apoptosis Cardiovasc Res, February 1, 2000; 45(3): 528 - 537. [Abstract] [Full Text] [PDF]
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H. Yaoita, K. Ogawa, K. Maehara, and Y. Maruyama Apoptosis in relevant clinical situations: contribution of apoptosis in myocardial infarction Cardiovasc Res, February 1, 2000; 45(3): 630 - 641. [Abstract] [Full Text] [PDF]
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Z.-Q. Zhao, M. Nakamura, N.-P. Wang, J. N. Wilcox, S. Shearer, R. S. Ronson, R. A. Guyton, and J. Vinten-Johansen Reperfusion induces myocardial apoptotic cell death Cardiovasc Res, February 1, 2000; 45(3): 651 - 660. [Abstract] [Full Text] [PDF]
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G. D. Dispersyn, M. Borgers, and W. Flameng Apoptosis in chronic hibernating myocardium: sleeping to death? Cardiovasc Res, February 1, 2000; 45(3): 696 - 703. [Abstract] [Full Text] [PDF]
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H. N. Sabbah Apoptotic cell death in heart failure Cardiovasc Res, February 1, 2000; 45(3): 704 - 712. [Full Text] [PDF]
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