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(Circulation. 1997;96:1755-1760.)
© 1997 American Heart Association, Inc.
Articles |
Active Serum Vitamin D Levels Are Inversely Correlated With Coronary Calcification
From the Division of Cardiology (K.E.W., M.L.A., L.L.M., L.L.D.), Department of Medicine and Department of Physiology, University of California, Los Angeles School of Medicine; Molecular Disease Branch (J.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology (T.D., R.D.), Harbor-University of California, Los Angeles Medical Center.
Correspondence to Karol E. Watson, MD, 47-123 Center for Health Sciences, UCLA School of Medicine, Los Angeles, CA 90095. E-mail kwatson{at}medicine.medsch.ucla.edu
Background Arterial calcification is a common feature of atherosclerosis, occurring in >90% of angiographically significant lesions. Recent evidence from this and other studies suggests that development of atherosclerotic calcification is similar to osteogenesis; thus, we undertook the current investigation on the potential role of osteoregulatory factors in arterial calcification.
Methods and Results We studied two human populations (173
subjects) at high and moderate risk for coronary heart disease
and assessed them for associations between vascular calcification and
serum levels of the osteoregulatory molecules osteocalcin, parathyroid
hormone, and 1
,25-dihydroxyvitamin D3 (1,25-vitamin D).
Our results revealed that 1,25-vitamin D levels are inversely
correlated with the extent of vascular calcification in both groups. No
correlations were found between extent of calcification and levels of
osteocalcin or parathyroid hormone.
Conclusions These data suggest a possible role for vitamin D in the development of vascular calcification. Vitamin D is also known to be important in bone mineralization; thus, 1,25-vitamin D may be one factor to explain the long observed association between osteoporosis and vascular calcification.
Key Words: calcium • coronary disease • hypercholesterolemia
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