From the Copenhagen Male Study, Epidemiological Research Unit (J.J.,
H.O.H., P.S., F.G.), Copenhagen University Hospital, and the Glostrup
Population Studies (H.O.H.), Department of Internal Medicine C, Glostrup
University Hospital, Denmark.
Correspondence to Dr Jørgen Jeppesen, The Copenhagen Male Study, Epidemiological Research Unit, Copenhagen University Hospital, Bispebjerg, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
Background—The role of
triglycerides as a risk factor of ischemic heart
disease (IHD) remains controversial. For the present study, we
examined the relation between fasting triglycerides and
risk of IHD in the Copenhagen Male Study.
Methods and Results—Baseline measurements of fasting lipids and
other IHD risk factors were obtained for 2906 white men (age range, 53
to 74 years) who were initially free of overt
cardiovascular disease. During an 8-year follow-up
period, 229 men had a first IHD event. Crude cumulative incidence rates
of IHD were 4.6% for the lowest, 7.7% for the middle, and 11.5% for
the highest third of triglyceride levels (P
for trend <.001). Compared with the lowest third level and adjusted
for age, body mass index, alcohol, smoking, physical activity,
hypertension, non–insulin-dependent diabetes mellitus, social class,
and LDL and HDL cholesterol, relative risks of IHD (95%
confidence interval) were 1.5 (1.0 to 2.3; P=.05) and
2.2 (1.4 to 3.4; P<.001) for the middle and highest
third of triglyceride levels, respectively. When
triglyceride levels were stratified by HDL
cholesterol levels (triglyceride third
multiplied by HDL cholesterol third), a clear gradient of
risk of IHD was found with increasing triglyceride levels
within each level of HDL cholesterol, including high HDL
cholesterol level, which are thought to provide protection
against IHD.
Conclusions—In middle-aged and elderly white men, a high level of
fasting triglycerides is a strong risk factor of IHD
independent of other major risk factors, including HDL
cholesterol.
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports
Triglyceride Concentration and Ischemic Heart Disease
An Eight-Year Follow-up in the Copenhagen Male Study
Key Words: coronary disease • lipids • lipoproteins • risk factors
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 T. Kwok, J. Woo, S. Ho, and A. Sham Vegetarianism and Ischemic Heart Disease in Older Chinese Women J. Am. Coll. Nutr., October 1, 2000; 19(5): 622 - 627. [Abstract] [Full Text] [PDF]
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K. D Stark, E. J Park, V. A Maines, and B. J Holub Effect of a fish-oil concentrate on serum lipids in postmenopausal women receiving and not receiving hormone replacement therapy in a placebo-controlled, double-blind trial Am. J. Clinical Nutrition, August 1, 2000; 72(2): 389 - 394. [Abstract] [Full Text] [PDF]
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 J. Jeppesen, H. O. Hein, P. Suadicani, and F. Gyntelberg High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease Hypertension, August 1, 2000; 36(2): 226 - 232. [Abstract] [Full Text] [PDF]
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F. G. McMahon, K. Fujioka, B. N. Singh, C. M. Mendel, E. Rowe, K. Rolston, F. Johnson, and A. D. Mooradian Efficacy and Safety of Sibutramine in Obese White and African American Patients With Hypertension: A 1-Year, Double-blind, Placebo-Controlled, Multicenter Trial Arch Intern Med, July 24, 2000; 160(14): 2185 - 2191. [Abstract] [Full Text] [PDF]
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M. A. Austin, B. McKnight, K. L. Edwards, C. M. Bradley, M. J. McNeely, B. M. Psaty, J. D. Brunzell, and A. G. Motulsky Cardiovascular Disease Mortality in Familial Forms of Hypertriglyceridemia: A 20-Year Prospective Study Circulation, June 20, 2000; 101(24): 2777 - 2782. [Abstract] [Full Text] [PDF]
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A. Oberman Hypertriglyceridemia and Coronary Heart Disease J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2098 - 2105. [Full Text]
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 G. Hufnagel, C. Michel, F. Vrtovsnik, G. Queffeulou, N. Kossari, and F. Mignon Effects of atorvastatin on dyslipidaemia in uraemic patients on peritoneal dialysis Nephrol. Dial. Transplant., May 1, 2000; 15(5): 684 - 688. [Abstract] [Full Text] [PDF]
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P. Benlian, C. Cansier, G. Hennache, O. Khallouf, P. Bayer, F. Duron, F. Carrat, R. Couderc, O. Chazouilleres, J. Bardet, et al. Comparison of a New Method for the Direct and Simultaneous Assessment of LDL- and HDL-Cholesterol with Ultracentrifugation and Established Methods Clin. Chem., April 1, 2000; 46(4): 493 - 505. [Abstract] [Full Text] [PDF]
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K. Tsukamoto, C. Maugeais, J. M. Glick, and D. J. Rader Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice J. Lipid Res., February 1, 2000; 41(2): 253 - 259. [Abstract] [Full Text]
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R. A. P. Skyrme-Jones, R. C. O'Brien, M. Luo, and I. T. Meredith Endothelial vasodilator function is related to low-density lipoprotein particle size and low-density lipoprotein vitamin E content in type 1 diabetes J. Am. Coll. Cardiol., February 1, 2000; 35(2): 292 - 299. [Abstract] [Full Text] [PDF]
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 J. D. Jones and M. L. Chambliss Hypertriglyceridemia and Coronary Heart Disease Arch Fam Med, February 1, 2000; 9(2): 189 - 190. [Full Text] [PDF]
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J. Syrjanen, J. Mustonen, and A. Pasternack Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy Nephrol. Dial. Transplant., January 1, 2000; 15(1): 34 - 42. [Abstract] [Full Text] [PDF]
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W. B Grant Low-fat, high-sugar diet and lipoprotein profiles Am. J. Clinical Nutrition, December 1, 1999; 70(6): 1111 - 1112. [Full Text] [PDF]
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K. J. Harjai Potential New Cardiovascular Risk Factors: Left Ventricular Hypertrophy, Homocysteine, Lipoprotein(a), Triglycerides, Oxidative Stress, and Fibrinogen Ann Intern Med, September 7, 1999; 131(5): 376 - 386. [Abstract] [Full Text] [PDF]
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M. Haim, M. Benderly, D. Brunner, S. Behar, E. Graff, H. Reicher-Reiss, and U. Goldbourt Elevated Serum Triglyceride Levels and Long-Term Mortality in Patients With Coronary Heart Disease : The Bezafibrate Infarction Prevention (BIP) Registry Circulation, August 3, 1999; 100(5): 475 - 482. [Abstract] [Full Text] [PDF]
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G. B. Schnell, A. Robertson, D. Houston, L. Malley, and T. J. Anderson Impaired brachial artery endothelial function is not predicted by elevated triglycerides J. Am. Coll. Cardiol., June 1, 1999; 33(7): 2038 - 2043. [Abstract] [Full Text] [PDF]
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R. J. Gibbons, K. Chatterjee, J. Daley, J. S. Douglas, S. D. Fihn, J. M. Gardin, M. A. Grunwald, D. Levy, B. W. Lytle, R. A. O'Rourke, et al. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina) J. Am. Coll. Cardiol., June 1, 1999; 33(7): 2092 - 2197. [Full Text] [PDF]
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H. H. Wittrup, A. Tybjærg-Hansen, R. Steffensen, S. S. Deeb, J. D. Brunzell, G. Jensen, and B. G. Nordestgaard Mutations in the lipoprotein lipase Gene Associated With Ischemic Heart Disease in Men : The Copenhagen City Heart Study Arterioscler Thromb Vasc Biol, June 1, 1999; 19(6): 1535 - 1540. [Abstract] [Full Text] [PDF]
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K. Kugiyama, T. Motoyama, H. Doi, H. Kawano, N. Hirai, H. Soejima, Y. Miyao, K. Takazoe, Y. Moriyama, Y. Mizuno, et al. Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoproteins levels J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1512 - 1518. [Abstract] [Full Text] [PDF]
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M. Orth, W. Weng, H. Funke, A. Steinmetz, G. Assmann, M. Nauck, J. Dierkes, A. Ambrosch, K. H. Weisgraber, R. W. Mahley, et al. Effects of a Frequent Apolipoprotein E Isoform, ApoE4Freiburg (Leu28->Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1306 - 1315. [Abstract] [Full Text] [PDF]
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A. von Eckardstein, H. Schulte, and G. Assmann Increased Risk of Myocardial Infarction in Men With Both Hypertriglyceridemia and Elevated HDL Cholesterol Circulation, April 13, 1999; 99 (14): 1922 - 1926. [Full Text] [PDF]
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O.-P. Pitkanen, P. Nuutila, O. T. Raitakari, K. Porkka, H. Iida, I. Nuotio, T. Ronnemaa, J. Viikari, M.-R. Taskinen, C. Ehnholm, et al. Coronary Flow Reserve in Young Men With Familial Combined Hyperlipidemia Circulation, April 6, 1999; 99(13): 1678 - 1684. [Abstract] [Full Text] [PDF]
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 E. A. Enas, B. Lamarche, G. R. Dagenais, and J.-P. Despres Triglycerides and Small, Dense Low-Density Lipoprotein JAMA, December 16, 1998; 280(23): 1990 - 1991. [Full Text] [PDF]
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A. M. Gotto Jr Triglyceride : The Forgotten Risk Factor Circulation, March 24, 1998; 97(11): 1027 - 1028. [Full Text] [PDF]
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