From the Division of Cardiovascular Diseases and Internal Medicine, Mayo
Clinic and Mayo Foundation, Rochester, Minn.
Background—Increasingly,
dobutamine stress echocardiography has
been used for detection of coronary artery disease. Less
information exists regarding the incremental prognostic value of the
test, including semiquantitative wall scoring, compared with clinical
and rest echocardiographic variables.
Methods and Results—Follow-up information was obtained from
860 patients who underwent dobutamine stress
echocardiography over a 2-year period. To determine
the value of dobutamine stress
echocardiography in predicting cardiac events,
including cardiac death and myocardial infarction, clinical and rest
and stress echocardiographic data were considered in a
stepwise Cox multivariate regression model. During
follow-up of up to 52 months, 72 patients underwent coronary
revascularization before any cardiac event and were
censored. Eighty-six patients had cardiac events, including nonfatal
myocardial infarction in 36 and cardiac death in 50. In a
multivariate model, a history of congestive heart
failure, the percentage of abnormal segments at peak stress, and an
abnormal left ventricular end-systolic volume
response to stress were independent predictors of cardiac events. The
model that best predicted subsequent cardiac events included clinical
and stress echocardiographic data.
Conclusions—Dobutamine stress
echocardiography with semiquantitative segmental
wall scoring provides important incremental information in predicting
subsequent cardiac events.
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports
Role of Dobutamine Stress Echocardiography in Predicting Outcome in 860 Patients With Known or Suspected Coronary Artery Disease
Key Words: coronary disease • echocardiography • prognosis • stress
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|
|
|
|
|
|
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|
|
|
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