From the Institut National de la Santé et de la Recherche
Médicale, IFR "Circulation Lariboisière," INSERM U
141 (Z.M., A.T.) and INSERM U 348 (M.L., J.M.), Hôpital
Lariboisière, Paris, and Service de Chirurgie Cardiovasculaire (I.P.,
D.C.), Hôpital Bichat, Paris, France. Correspondence to Alain Tedgui,
PhD, INSERM U 141, 41 boulevard de la Chapelle, 75475 Paris Cedex 10, France.
Background—It has been suggested
that oxidant stress may play a role in the pathophysiology of heart
failure. However, no definitive information is available because most
previous approaches used to measure oxidant stress are nonspecific,
inaccurate, and unreliable.
Methods and Results—To evaluate oxidant stress in the heart, we
measured pericardial fluid levels of 8-iso-prostaglandin
F2
Conclusions—Pericardial levels of 8-iso-PGF2
© 1998 American Heart Association, Inc.
Brief Rapid Communications
Elevated Levels of 8-iso-Prostaglandin F2
in Pericardial Fluid of Patients With Heart Failure
A Potential Role for In Vivo Oxidant Stress in Ventricular Dilatation and Progression to Heart Failure
(8-iso-PGF2), a specific and
quantitative marker of oxidant stress in vivo, in a series of 51
consecutive patients with ischemic and/or valvular
heart disease referred for cardiac surgery. Pericardial levels of
8-iso-PGF2 were correlated with the functional severity
of heart failure (NYHA classification) and with
echocardiographic indices of ventricular
dilatation measured by independent physicians. Pericardial levels of
8-iso-PGF2 were significantly increased in patients with
symptomatic heart failure compared with
asymptomatic patients and gradually increased with the
functional severity of heart failure (P=.0003). In
addition, pericardial levels of 8-iso-PGF2 were
significantly correlated with left ventricular
end-diastolic and end-systolic diameters
(P=.008 and .026, respectively).
increase with the functional severity of heart failure and are
associated with ventricular dilatation. These data suggest
an important role for in vivo oxidant stress on ventricular
remodeling and the progression to heart failure.
Key Words: heart failure • free radicals • pericardium
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|
|
|
 |
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|
|
|
|
|
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|
|
|
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|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 T. Heitzer, S. Baldus, Y. von Kodolitsch, V. Rudolph, and T. Meinertz Systemic Endothelial Dysfunction as an Early Predictor of Adverse Outcome in Heart Failure Arterioscler. Thromb. Vasc. Biol., June 1, 2005; 25(6): 1174 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 P. MONTUSCHI, P. J. BARNES, and L. J. ROBERTS II Isoprostanes: markers and mediators of oxidative stress FASEB J, December 1, 2004; 18(15): 1791 - 1800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jekell, A. Hossain, U. Alehagen, U. Dahlstrom, and A. Rosen Elevated circulating levels of thioredoxin and stress in chronic heart failure Eur J Heart Fail, December 1, 2004; 6(7): 883 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Tomaselli and D. P. Zipes What Causes Sudden Death in Heart Failure? Circ. Res., October 15, 2004; 95(8): 754 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Cracowski and O. Ormezzano Isoprostanes, emerging biomarkers and potential mediators in cardiovascular diseases Eur. Heart J., October 1, 2004; 25(19): 1675 - 1678. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Svatikova, R. Wolk, H. H. Wang, M. E. Otto, K. A. Bybee, R. J. Singh, and V. K. Somers Circulating free nitrotyrosine in obstructive sleep apnea Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R284 - R287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Valgimigli, E. Merli, P. Malagutti, O. Soukhomovskaia, G. Cicchitelli, A. Antelli, D. Canistro, G. Francolini, G. Macri, F. Mastrorilli, et al. Hydroxyl radical generation, levels of tumor necrosis factor-alpha, and progression to heart failure after acute myocardial infarction J. Am. Coll. Cardiol., June 2, 2004; 43(11): 2000 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hokamaki, H. Kawano, M. Yoshimura, H. Soejima, S. Miyamoto, I. Kajiwara, S. Kojima, T. Sakamoto, S. Sugiyama, N. Hirai, et al. Urinary biopyrrins levels are elevated in relation to severity of heart failure J. Am. Coll. Cardiol., May 19, 2004; 43(10): 1880 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kameda, T. Matsunaga, N. Abe, H. Hanada, H. Ishizaka, H. Ono, M. Saitoh, K. Fukui, I. Fukuda, T. Osanai, et al. Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease: Possible role for left ventricular remodelling Eur. Heart J., December 2, 2003; 24(24): 2180 - 2185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Griendling and G. A. FitzGerald Oxidative Stress and Cardiovascular Injury: Part II: Animal and Human Studies Circulation, October 28, 2003; 108(17): 2034 - 2040. [Full Text] [PDF]
|
|
|
|
|
|
C. Maack, T. Kartes, H. Kilter, H.-J. Schafers, G. Nickenig, M. Bohm, and U. Laufs Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment Circulation, September 30, 2003; 108(13): 1567 - 1574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kogler, H. Fraser, S. McCune, R. Altschuld, and E. Marban Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium Cardiovasc Res, September 1, 2003; 59(3): 582 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J-L Cracowski The putative role of isoprostanes in human cardiovascular physiology and disease: following the fingerprints Heart, August 1, 2003; 89(8): 821 - 822. [Full Text] [PDF]
|
|
|
|
|
|
M Nonaka-Sarukawa, K Yamamoto, H Aoki, H Takano, T Katsuki, U Ikeda, and K Shimada Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stress Heart, August 1, 2003; 89(8): 871 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. P. Cappola, L. Cope, A. Cernetich, L. A. Barouch, K. Minhas, R. A. Irizarry, G. Parmigiani, S. Durrani, T. Lavoie, E. P. Hoffman, et al. Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy Physiol Genomics, June 24, 2003; 14(1): 25 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Heymes, J. K. Bendall, P. Ratajczak, A. C. Cave, J.-L. Samuel, G. Hasenfuss, and A. M. Shah Increased myocardial NADPH oxidase activity in human heart failure J. Am. Coll. Cardiol., June 18, 2003; 41(12): 2164 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Warnholtz and T. Munzel The failing human heart: Another battlefield for the NAD(P)H oxidase? J. Am. Coll. Cardiol., June 18, 2003; 41(12): 2172 - 2174. [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, R. Vezza, T. Plappert, P. McNamara, J. A. Lawson, S. Austin, D. Pratico, M. S.-J. Sutton, and G. A. FitzGerald COX-2-Dependent Cardiac Failure in Gh/tTG Transgenic Mice Circ. Res., May 30, 2003; 92(10): 1153 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Machida, T. Kubota, N. Kawamura, H. Funakoshi, T. Ide, H. Utsumi, Y. Y. Li, A. M. Feldman, H. Tsutsui, H. Shimokawa, et al. Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H449 - H455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nakamura, K. Egashira, Y. Machida, S. Hayashidani, M. Takeya, H. Utsumi, H. Tsutsui, and A. Takeshita Probucol Attenuates Left Ventricular Dysfunction and Remodeling in Tachycardia-Induced Heart Failure: Roles of Oxidative Stress and Inflammation Circulation, July 16, 2002; 106(3): 362 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakamura, K. Kusano, Y. Nakamura, M. Kakishita, K. Ohta, S. Nagase, M. Yamamoto, K. Miyaji, H. Saito, H. Morita, et al. Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium Circulation, June 18, 2002; 105(24): 2867 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsutsui, T. Tsutamoto, A. Wada, K. Maeda, N. Mabuchi, M. Hayashi, M. Ohnishi, and M. Kinoshita Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure J. Am. Coll. Cardiol., March 20, 2002; 39(6): 957 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Saavedra, N. Paolocci, M. E. St. John, M. W. Skaf, G. C. Stewart, J.-S. Xie, R. W. Harrison, J. Zeichner, D. Mudrick, E. Marban, et al. Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart Circ. Res., February 22, 2002; 90(3): 297 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mak and G. E. Newton The Oxidative Stress Hypothesis of Congestive Heart Failure : Radical Thoughts Chest, December 1, 2001; 120(6): 2035 - 2046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
R. Nakamura, K. Egashira, K. Arimura, Y. Machida, T. Ide, H. Tsutsui, H. Shimokawa, and A. Takeshita Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2619 - H2625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
L. T. McGrath, R. Patrick, and B. Silke Breath isoprene in patients with heart failure Eur J Heart Fail, August 1, 2001; 3(4): 423 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Schimke, J. Muller, F. Priem, I. Kruse, B. Schon, J. Stein, R. Kunze, G. Wallukat, and R. Hetzer Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption J. Am. Coll. Cardiol., July 1, 2001; 38(1): 178 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsutamoto, A. Wada, T. Matsumoto, K. Maeda, N. Mabuchi, M. Hayashi, T. Tsutsui, M. Ohnishi, M. Sawaki, M. Fujii, et al. Relationship between tumor necrosis factor-alpha production and oxidative stress in the failing hearts of patients with dilated cardiomyopathy J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2086 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Janssen Isoprostanes: an overview and putative roles in pulmonary pathophysiology Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1067 - L1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ukai, C.-P. Cheng, H. Tachibana, A. Igawa, Z.-S. Zhang, H.-J. Cheng, and W. C. Little Allopurinol Enhances the Contractile Response to Dobutamine and Exercise in Dogs With Pacing-Induced Heart Failure Circulation, February 6, 2001; 103(5): 750 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E Keith, K. N Jeejeebhoy, A. Langer, R. Kurian, A. Barr, B. O'Kelly, and M. J Sole A controlled clinical trial of vitamin E supplementation in patients with congestive heart failure Am. J. Clinical Nutrition, February 1, 2001; 73(2): 219 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Siwik, P. J. Pagano, and W. S. Colucci Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts Am J Physiol Cell Physiol, January 1, 2001; 280(1): C53 - C60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Arimura, K. Egashira, R. Nakamura, T. Ide, H. Tsutsui, H. Shimokawa, and A. Takeshita Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H68 - H75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tsutsui, T. Ide, S. Hayashidani, N. Suematsu, H. Utsumi, R. Nakamura, K. Egashira, and A. Takeshita Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury Cardiovasc Res, January 1, 2001; 49(1): 103 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Halliwell Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovasc Res, August 18, 2000; 47(3): 410 - 418. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Moriyama, H. Yasue, M. Yoshimura, Y. Mizuno, K. Nishiyama, R. Tsunoda, H. Kawano, K. Kugiyama, H. Ogawa, Y. Saito, et al. The Plasma Levels of Dehydroepiandrosterone Sulfate Are Decreased in Patients with Chronic Heart Failure in Proportion to the Severity J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 1834 - 1840. [Abstract] [Full Text]
|
|
|
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T. Ide, H. Tsutsui, S. Kinugawa, N. Suematsu, S. Hayashidani, K. Ichikawa, H. Utsumi, Y. Machida, K. Egashira, and A. Takeshita Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium Circ. Res., February 4, 2000; 86(2): 152 - 157. [Abstract] [Full Text] [PDF]
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 H. Li, J. A. Lawson, M. Reilly, M. Adiyaman, S.-W. Hwang, J. Rokach, and G. A. FitzGerald Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F2-isoprostanes in human urine PNAS, November 9, 1999; 96(23): 13381 - 13386. [Abstract] [Full Text] [PDF]
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S.A. Cook and P.A. Poole-Wilson Cardiac myocyte apoptosis Eur. Heart J., November 2, 1999; 20(22): 1619 - 1629. [PDF]
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J. A. Lawson, J. Rokach, and G. A. FitzGerald Isoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo J. Biol. Chem., August 27, 1999; 274(35): 24441 - 24444. [Full Text] [PDF]
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T. Ide, H. Tsutsui, S. Kinugawa, H. Utsumi, D. Kang, N. Hattori, K. Uchida, K.-i. Arimura, K. Egashira, and A. Takeshita Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium Circ. Res., August 20, 1999; 85(4): 357 - 363. [Abstract] [Full Text] [PDF]
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T. Ide, H. Tsutsui, S. Kinugawa, H. Utsumi, and A. Takeshita Amiodarone Protects Cardiac Myocytes Against Oxidative Injury by its Free Radical Scavenging Action Circulation, August 17, 1999; 100(7): 690 - 692. [Abstract] [Full Text] [PDF]
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M. Reza Mehrabi, C. Ekmekcioglu, F. Tatzber, A. Oguogho, R. Ullrich, A. Morgan, F. Tamaddon, M. Grimm, H. D Glogar, and H. Sinzinger The isoprostane, 8-epi-PGF2{alpha}, is accumulated in coronary arteries isolated from patients with coronary heart disease Cardiovasc Res, August 1, 1999; 43(2): 492 - 499. [Abstract] [Full Text] [PDF]
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D. A. Siwik, J. D. Tzortzis, D. R. Pimental, D. L.-F. Chang, P. J. Pagano, K. Singh, D. B. Sawyer, and W. S. Colucci Inhibition of Copper-Zinc Superoxide Dismutase Induces Cell Growth, Hypertrophic Phenotype, and Apoptosis in Neonatal Rat Cardiac Myocytes In Vitro Circ. Res., July 23, 1999; 85(2): 147 - 153. [Abstract] [Full Text] [PDF]
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T. Munzel and D. G. Harrison Increased Superoxide in Heart Failure : A Biochemical Baroreflex Gone Awry Circulation, July 20, 1999; 100(3): 216 - 218. [Full Text] [PDF]
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W. F. Saavedra, N. Paolocci, M. E. St. John, M. W. Skaf, G. C. Stewart, J.-S. Xie, R. W. Harrison, J. Zeichner, D. Mudrick, E. Marban, et al. Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart Circ. Res., February 22, 2002; 90(3): 297 - 304. [Abstract] [Full Text] [PDF]
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F. Sam, D. B. Sawyer, Z. Xie, D. L.F. Chang, S. Ngoy, D. A. Brenner, D. A. Siwik, K. Singh, C. S. Apstein, and W. S. Colucci Mice Lacking Inducible Nitric Oxide Synthase Have Improved Left Ventricular Contractile Function and Reduced Apoptotic Cell Death Late After Myocardial Infarction Circ. Res., August 17, 2001; 89(4): 351 - 356. [Abstract] [Full Text] [PDF]
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