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From the Cardiovascular Research Laboratories, Division of Cardiology,
University of Pittsburgh Medical Center, Pittsburgh, Pa (T.K., D.M.M., J.J.W.,
M.T., C.F.M., A.M.F.), and the Cardiology Section of the Department of
Medicine, Veterans Administration Medical Center and Baylor College of
Medicine, Houston, Tex (D.L.M.).
Correspondence to Dennis M. McNamara, MD, Division of Cardiology, University of Pittsburgh Medical Center, 200 Lothrop St, 558 Scaife Hall, Pittsburgh, PA 15213. E-mail mcnama{at}msx.upmc.edu
Background—Tumor
necrosis factor-
Methods and Results—TNFA and TNFB genotypes were
determined by the polymerase chain reaction–restriction fragment
length polymorphism technique. There were no differences in the TNF
allele frequencies between CHF (n=229; TNFA1/2=0.84/0.16,
TNFB1/2=0.33/0.67) and control subjects (n=139; TNFA1/2=0.84/0.16,
TNFB1/2=0.32/0.68). In 211 patients with CHF, circulating levels of
TNF-
Conclusions—Despite their association with other inflammatory
diseases, neither TNFA nor TNFB polymorphisms are related to the
presence of CHF or the elevation of circulating TNF-
© 1998 American Heart Association, Inc.
Brief Rapid Communications
Effects of Tumor Necrosis Factor Gene Polymorphisms on Patients With Congestive Heart Failure
(TNF-) is known to be elevated in
patients with congestive heart failure (CHF). Two biallelic
polymorphisms have been identified in the TNF gene locus: one in
the promoter region of TNF- (TNFA1/2), and the other in the first
intron of TNF-ß (TNFB1/2). Both TNFA2 and TNFB2 alleles are
associated with high TNF- production in vitro and
susceptibility to inflammatory diseases. Given the importance of
TNF- in the pathogenesis of CHF, we studied the prevalence of TNF
gene polymorphisms in CHF patients and the correlation of
genotypes to in vivo TNF- levels. and the soluble receptors type I and type II were measured by
ELISA: 6.18±3.59 pg/mL, 1768±761 pg/mL, and 4484±1750 pg/mL,
respectively. There were no correlations between TNFA or TNFB
genotypes and circulating levels of TNF- or its soluble
receptors in the CHF patients. . Thus, other
factors may be more important in determining the circulating levels of
TNF- in CHF.
Key Words: genetics • heart failure • immunology
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