From INSERM U397 (R.E., A.M., J.F.A., F.B.) and INSERM U466 (M.-T.P.,
J.C.T.), Institut L. Bugnard, CHU Rangueil, Toulouse, France.
Correspondence to Francis Bayard, INSERM U397, Institut L. Bugnard, CHU Rangueil, 1 ave Jean Poulhès, 31054 Toulouse Cédex, France. E-mail bayard{at}rangueil.inserm.fr
Background—The cytokines
interleukin 1 (IL-1) and tumor necrosis factor (TNF) are secreted by
the different cell populations of the vascular wall and have been
suggested to promote atherosclerosis.
Methods and Results—Their respective roles in fatty-streak
formation in apolipoprotein E–deficient mice were investigated by use
of IL-1 receptor antagonist and TNF binding protein.
Estradiol-17ß was used as a positive control. Blocking TNF seemed to
be active in female animals but not in males. IL-1 receptor
antagonist was as effective as or more effective than
estradiol in both sexes.
Conclusions—IL-1 plays a crucial role in the initial step of the
atherosclerotic process in this animal model, and blocking the activity
of this cytokine should be considered as a therapeutic
possibility.
© 1998 American Heart Association, Inc.
Brief Rapid Communications
Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice
Key Words: atherosclerosis • apolipoproteins • interleukins • tumor necrosis factor
This article has been cited by other articles:
 |
|
 |
|
  C. Monaco, S. M. Gregan, T. J. Navin, B. M.J. Foxwell, A. H. Davies, and M. Feldmann Toll-Like Receptor-2 Mediates Inflammation and Matrix Degradation in Human Atherosclerosis Circulation, December 15, 2009; 120(24): 2462 - 2469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kleemann, S. Zadelaar, and T. Kooistra Cytokines and atherosclerosis: a comprehensive review of studies in mice Cardiovasc Res, August 1, 2008; 79(3): 360 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Loppnow, K. Werdan, and M. Buerke Invited review: Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms Innate Immunity, April 1, 2008; 14(2): 63 - 87. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Kawamura, D. Baitsch, R. Telgmann, R. Feuerborn, G. Weissen-Plenz, C. Hagedorn, K. Saku, S.-M. Brand-Herrmann, A. von Eckardstein, G. Assmann, et al. Apolipoprotein E Interrupts Interleukin-1{beta} Signaling in Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, July 1, 2007; 27(7): 1610 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tedgui and Z. Mallat Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways Physiol Rev, April 1, 2006; 86(2): 515 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Merhi-Soussi, B. R. Kwak, D. Magne, C. Chadjichristos, M. Berti, G. Pelli, R. W. James, F. Mach, and C. Gabay Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice Cardiovasc Res, June 1, 2005; 66(3): 583 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. R. Su, D. E. Dove, A. S. Major, A. H. Hasty, B. Boone, M. F. Linton, and S. Fazio Reduced ABCA1-Mediated Cholesterol Efflux and Accelerated Atherosclerosis in Apolipoprotein E-Deficient Mice Lacking Macrophage-Derived ACAT1 Circulation, May 10, 2005; 111(18): 2373 - 2381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S.M. Boesten, A. S. M. Zadelaar, A. van Nieuwkoop, M. J.J. Gijbels, M. P.J. de Winther, L. M. Havekes, and B. J.M. van Vlijmen Tumor necrosis factor-{alpha} promotes atherosclerotic lesion progression in APOE*3-leiden transgenic mice Cardiovasc Res, April 1, 2005; 66(1): 179 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lu, M. Raptis, E. Black, M. Stan, S. Amar, and D. T. Graves Influence of Diabetes on the Exacerbation of an Inflammatory Response in Cardiovascular Tissue Endocrinology, November 1, 2004; 145(11): 4934 - 4939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chi, E. Messas, R. A. Levine, D. T. Graves, and S. Amar Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model: Pharmacotherapeutic Implications Circulation, September 21, 2004; 110(12): 1678 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification Endocr. Rev., August 1, 2004; 25(4): 629 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Wilson, S. E. Francis, S. K. Dower, and D. C. Crossman Secretion of Intracellular IL-1 Receptor Antagonist (Type 1) Is Dependent on P2X7 Receptor Activation J. Immunol., July 15, 2004; 173(2): 1202 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Epstein, E. Stabile, T. Kinnaird, C. W. Lee, L. Clavijo, and M. S. Burnett Janus Phenomenon: The Interrelated Tradeoffs Inherent in Therapies Designed to Enhance Collateral Formation and Those Designed to Inhibit Atherogenesis Circulation, June 15, 2004; 109(23): 2826 - 2831. [Full Text] [PDF]
|
|
|
|
|
|
K. Isoda, S. Sawada, N. Ishigami, T. Matsuki, K. Miyazaki, M. Kusuhara, Y. Iwakura, and F. Ohsuzu Lack of Interleukin-1 Receptor Antagonist Modulates Plaque Composition in Apolipoprotein E-Deficient Mice Arterioscler Thromb Vasc Biol, June 1, 2004; 24(6): 1068 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. OSTERUD and E. BJORKLID Role of Monocytes in Atherogenesis Physiol Rev, October 1, 2003; 83(4): 1069 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Von der Thusen, J. Kuiper, T. J. C. Van Berkel, and E. A. L. Biessen Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential Pharmacol. Rev., March 1, 2003; 55(1): 133 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kozaki, W. E. Kaminski, J. Tang, S. Hollenbach, P. Lindahl, C. Sullivan, J.-C. Yu, K. Abe, P. J. Martin, R. Ross, et al. Blockade of Platelet-Derived Growth Factor or Its Receptors Transiently Delays but Does Not Prevent Fibrous Cap Formation in ApoE Null Mice Am. J. Pathol., October 1, 2002; 161(4): 1395 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Zimmerman, C. H. Selzman, L. L. Reznikov, S. A. Miller, C. D. Raeburn, J. Emmick, X. Meng, and A. H. Harken Lack of TNF-alpha attenuates intimal hyperplasia after mouse carotid artery injury Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R505 - R512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Devlin, G. Kuriakose, E. Hirsch, and I. Tabas Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size PNAS, April 30, 2002; 99(9): 6280 - 6285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cattaruzza, K. Schafer, and M. Hecker Cytokine-induced Down-regulation of zfm1/Splicing Factor-1 Promotes Smooth Muscle Cell Proliferation J. Biol. Chem., February 15, 2002; 277(8): 6582 - 6589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz Changes in Proinflammatory Cytokine Activity after Menopause Endocr. Rev., February 1, 2002; 23(1): 90 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S E Francis, N J Camp, A J Burton, R M Dewberry, J Gunn, A Stephens-Lloyd, D C Cumberland, A Gershlick, and D C Crossman Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty Heart, September 1, 2001; 86(3): 336 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tedgui and Z. Mallat Anti-Inflammatory Mechanisms in the Vascular Wall Circ. Res., May 11, 2001; 88(9): 877 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dewberry, H. Holden, D. Crossman, and S. Francis Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis Arterioscler Thromb Vasc Biol, November 1, 2000; 20(11): 2394 - 2400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Kim, J. C. Khoo, K. Gillotte-Taylor, A. Li, W. Palinski, C. K. Glass, and D. Steinberg Polymerase Chain Reaction-Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo : Enhancement by Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Arterioscler Thromb Vasc Biol, August 1, 2000; 20(8): 1976 - 1982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. George, Y. Shoenfeld, B. Gilburd, A. Afek, A. Shaish, and D. Harats Requisite Role for Interleukin-4 in the Acceleration of Fatty Streaks Induced by Heat Shock Protein 65 or Mycobacterium tuberculosis Circ. Res., June 23, 2000; 86(12): 1203 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maret, S. Clamens, I. Delrieu, R. Elhage, J.-F. Arnal, and F. Bayard Expression of the Interleukin-6 Gene Is Constitutive and Not Regulated by Estrogen in Rat Vascular Smooth Muscle Cells in Culture Endocrinology, June 1, 1999; 140(6): 2876 - 2882. [Abstract] [Full Text]
|
|
|
|
|
|
S. E. Francis, N. J. Camp, R. M. Dewberry, J. Gunn, P. Syrris, N. D. Carter, S. Jeffery, J. C. Kaski, D. C. Cumberland, G. W. Duff, et al. Interleukin-1 Receptor Antagonist Gene Polymorphism and Coronary Artery Disease Circulation, February 23, 1999; 99(7): 861 - 866. [Abstract] [Full Text] [PDF]
|
|