From the Division of Cardiology, Department of Medicine, Cedars-Sinai
Medical Center and the Department of Pathology (M.C.F.), University of
California, Los Angeles School of Medicine, Los Angeles, Calif.
Correspondence to Peng-Sheng Chen, MD, Room 5342, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048. E-mail chenp{at}csmc.edu
Background—The characteristics of
transmembrane potential (TMP) at the core of functional reentry in the
atrium are not well understood.
Methods and Results—In protocol 1 (11 dogs), isolated perfused
canine right atria were mapped from the endocardial surface while
simultaneous TMPs were recorded from the epicardial
surface. Episodes of reentry (n=64) were induced in the presence of 1
to 5 µmol/L acetylcholine. Successful simultaneous
TMP recordings and activation maps were made in 8 episodes. The
TMP was "near the core" if it was within 3.2 mm of the core;
otherwise, it was considered to be "in the periphery." The mean
cycle length of reentry was 110±35 ms. The TMP amplitude, duration
(90% repolarization), and (dV/dt)max near the core (n=106)
were 58±22 mV, 46±14 ms, and 33±20 V/s, respectively, significantly
less than those in the periphery (n=241): 70±8 mV, 94±32 ms, and
55±10 V/s (P<0.001 for all). In 2 episodes of reentry,
the cell at the core remained unexcited at its resting membrane
potential. In protocol 2 (2 dogs), we performed
simultaneous high-density mapping in 4 episodes of reentry
and showed synchronous activation patterns on both surfaces with
similar locations of the core.
Conclusions—During meandering functional reentry in isolated
canine right atria, (1) TMPs of cells near the core have a reduced
amplitude, duration, and (dV/dt)max, and (2) cells at the
core may remain unexcited at their resting membrane potential. These
findings are compatible with the spiral wave concept of functional
reentry in the atrium.
© 1998 American Heart Association, Inc.
Basic Science Reports
Transmembrane Potential Properties at the Core of Functional Reentrant Wave Fronts in Isolated Canine Right Atria
Key Words: waves • atrium • arrhythmia • tachycardia • electrophysiology
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