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Correspondence to Michel E. Bertrand, Dept de Cardiologie B, Hôpital Cardiologique, 59037 Lille, France. E-mail bertrandme{at}aol.com
Background—Dual therapy with
ticlopidine and aspirin has been shown to be as effective as or more
effective than conventional anticoagulation in patients with an optimal
result after implantation of intracoronary metallic stents.
However, the safety and efficacy of antiplatelet therapy alone in
an unselected population has not been evaluated.
Methods—Patients were randomized to conventional anticoagulation
or to treatment with antiplatelet therapy alone. Indications for
stenting were classified as elective (decided before the procedure) or
unplanned (to salvage failed angioplasty or to optimize the results of
balloon angioplasty). After stenting, patients received aspirin and
either ticlopidine or conventional anticoagulation (heparin or oral
anticoagulant). The primary end point was the occurrence of bleeding or
peripheral vascular complications; secondary end points
were cardiac events (death, infarction, or stent occlusion) and
duration of hospitalization.
Results—In 13 centers, 236 patients were randomized to
anticoagulation and 249 to antiplatelet therapy. Stenting was
elective in 58% of patients and unplanned in 42%. Stent implantation
was successfully achieved in 99% of patients. A primary end point
occurred in 33 patients (13.5%) in the antiplatelet group and 48
patients (21%) in the anticoagulation group (odds ratio=0.6 [95% CI
0.36 to 0.98], P=0.03). Major cardiac-related events in
electively stented patients were less common (odds ratio=0.23 [95% CI
0.05 to 0.91], P=0.01) in the antiplatelet group (3
of 123, 2.4%) than the anticoagulation group (11 of 111, 9.9%).
Hospital stay was significantly shorter in the antiplatelet group
(4.3±3.6 versus 6.4±3.7 days, P=0.0001).
Conclusions—Antiplatelet therapy after coronary
stenting significantly reduced rates of bleeding and subacute stent
occlusion compared with conventional anticoagulation.
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports
Randomized Multicenter Comparison of Conventional Anticoagulation Versus Antiplatelet Therapy in Unplanned and Elective Coronary Stenting
The Full Anticoagulation Versus Aspirin and Ticlopidine (FANTASTIC) Study
Key Words: stents • antiplatelet agents • anticoagulants
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|
|
|
 |
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|
|
|
|
 |
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 C.-C. Fang, Y. T. F. N. Jao, Y. Chen, and S.-P. Wang Coronary Stenting or Balloon Angioplasty for Chronic Total Coronary Occlusions: The Taiwan Experience (A Single-Center Report) Angiology, September 1, 2005; 56(5): 525 - 537. [Abstract] [PDF]
|
|
|
|
 |
|
 M. B. Rothberg, C. Celestin, L. D. Fiore, E. Lawler, and J. R. Cook Warfarin plus Aspirin after Myocardial Infarction or the Acute Coronary Syndrome: Meta-Analysis with Estimates of Risk and Benefit Ann Intern Med, August 16, 2005; 143(4): 241 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Wiviott, E. M. Antman, K. J. Winters, G. Weerakkody, S. A. Murphy, B. D. Behounek, R. J. Carney, C. Lazzam, R. G. McKay, C. H. McCabe, et al. Randomized Comparison of Prasugrel (CS-747, LY640315), a Novel Thienopyridine P2Y12 Antagonist, With Clopidogrel in Percutaneous Coronary Intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 Trial Circulation, June 28, 2005; 111(25): 3366 - 3373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wenaweser, C. Rey, F. R. Eberli, M. Togni, D. Tuller, S. Locher, A. Remondino, C. Seiler, O. M. Hess, B. Meier, et al. Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome Eur. Heart J., June 2, 2005; 26(12): 1180 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M.W. Bath, L. Zhao, and S. Heptinstall Current status of stroke prevention in patients with atrial fibrillation Eur. Heart J. Suppl., May 1, 2005; 7(suppl_C): C12 - C18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Buresly, M. J. Eisenberg, X. Zhang, and L. Pilote Bleeding Complications Associated With Combinations of Aspirin, Thienopyridine Derivatives, and Warfarin in Elderly Patients Following Acute Myocardial Infarction Arch Intern Med, April 11, 2005; 165(7): 784 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Authors/Task Force Members, S. Silber, P. Albertsson, F. F. Aviles, P. G. Camici, A. Colombo, C. Hamm, E. Jorgensen, J. Marco, J.-E. Nordrehaug, et al. Guidelines for Percutaneous Coronary Interventions: The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology Eur. Heart J., April 2, 2005; 26(8): 804 - 847. [Full Text] [PDF]
|
|
|
|
 |
|
 P. H Chong and J. W. Cheng Early Experiences and Clinical Implications of Restenosis and Drug-Eluting Stents: Part 2 Ann. Pharmacother., May 1, 2004; 38(5): 845 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S K Khambekar, J Kovac, and A H Gershlick Clopidogrel induced urticarial rash in a patient with left main stem percutaneous coronary intervention: management issues Heart, March 1, 2004; 90(3): e14 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Holmes Jr Risk Stratification and Interventional Cardiology: Robert L. Frye Lecture Mayo Clin. Proc., December 1, 2003; 78(12): 1507 - 1518. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Morrison Counterintuitive contributionsto the care of myocardialinfarction and theneed for randomized trials J. Am. Coll. Cardiol., September 17, 2003; 42(6): 978 - 980. [Full Text] [PDF]
|
|
|
|
|
|
R. Mehran, E. D. Aymong, D. T. Ashby, T. Fischell, H. Whitworth Jr, R. Siegel, W. Thomas, S. C. Wong, R. Narasimaiah, A. J. Lansky, et al. Safety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent: Final Results of the HOPE (HEPACOAT and an Antithrombotic Regimen of Aspirin Alone) Study Circulation, September 2, 2003; 108(9): 1078 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Berger Reply J. Am. Coll. Cardiol., April 16, 2003; 41(8): 1421 - 1421. [Full Text] [PDF]
|
|
|
|
|
|
T. R. Tolleson, J. C. O'Shea, J. A. Bittl, W. B. Hillegass, K. A. Williams, G. Levine, R. A. Harrington, and J. E. Tcheng Relationship between heparin anticoagulation and clinical outcomes in coronary stent intervention: observations from the ESPRIT trial J. Am. Coll. Cardiol., February 5, 2003; 41(3): 386 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Steinhubl, P. B. Berger, J. T. Mann III, E. T. A. Fry, A. DeLago, C. Wilmer, E. J. Topol, and for the CREDO Investigators Early and Sustained Dual Oral Antiplatelet Therapy Following Percutaneous Coronary Intervention: A Randomized Controlled Trial JAMA, November 20, 2002; 288(19): 2411 - 2420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Orford, R. Lennon, S. Melby, P. Fasseas, M. R. Bell, C. S. Rihal, D. R. Holmes, and P. B. Berger Frequency and correlates of coronary stent thrombosis in the modern era: Analysis of a single center registry J. Am. Coll. Cardiol., November 6, 2002; 40(9): 1567 - 1572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Hongo, J. Ley, S. E. Dick, and R. R. Yee The effect of clopidogrel incombination with aspirin whengiven before coronary artery bypass grafting J. Am. Coll. Cardiol., July 17, 2002; 40(2): 231 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Scheller A reply Eur. Heart J., January 2, 2002; 23(2): 176 - 177. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Mozes and P. Gloviczki Adjuvant Therapy in Lower Extremity Revascularization: Prevention of Early and Intermediate Failures Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 2002; 15(2): 161 - 180. [Abstract] [PDF]
|
|
|
|
|
|
J Wohrle, E Al-Khayer, U Grotzinger, C Schindler, M Kochs, V Hombach, and M Hoher Comparison of the heparin coated vs the uncoated Jostent(R)--no influence on restenosis or clinical outcome Eur. Heart J., October 1, 2001; 22(19): 1808 - 1816. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Montalescot, P. Barragan, O. Wittenberg, P. Ecollan, S. Elhadad, P. Villain, J.-M. Boulenc, M.-C. Morice, L. Maillard, M. Pansieri, et al. Platelet Glycoprotein IIb/IIIa Inhibition with Coronary Stenting for Acute Myocardial Infarction N. Engl. J. Med., June 21, 2001; 344(25): 1895 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schuhlen, A. Kastrati, J.u. Pache, J. Dirschinger, and A. Schomig Incidence of thrombotic occlusion and major adverse cardiac events between two and four weeks after coronary stent placement: analysis of 5,678 patients with a four-week ticlopidine regimen J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2066 - 2073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Steinhubl, S. G. Ellis, K. Wolski, A. M. Lincoff, and E. J. Topol Ticlopidine Pretreatment Before Coronary Stenting Is Associated With Sustained Decrease in Adverse Cardiac Events : Data From the Evaluation of Platelet IIb/IIIa Inhibitor for Stenting (EPISTENT) Trial Circulation, March 13, 2001; 103(10): 1403 - 1409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The Organization to Assess Strategies for Ischemic Effects of long-term, moderate-intensity oral anticoagulation in addition to aspirin in unstable angina J. Am. Coll. Cardiol., February 1, 2001; 37(2): 475 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Bhatt, D. P. Chew, A. T. Hirsch, P. A. Ringleb, W. Hacke, and E. J. Topol Superiority of Clopidogrel Versus Aspirin in Patients With Prior Cardiac Surgery Circulation, January 23, 2001; 103(3): 363 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
P.J. De Feyter and D. Foley Coronary stent implantation: a panacea for the interventional cardiologist? Eur. Heart J., November 1, 2000; 21(21): 1719 - 1726. [PDF]
|
|
|
|
|
|
J. Al Suwaidi, P. B. Berger, and D. R. Holmes Jr Coronary Artery Stents JAMA, October 11, 2000; 284(14): 1828 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Helft, J. I. Osende, S. G. Worthley, A. G. Zaman, O. J. Rodriguez, E. I. Lev, M. E. Farkouh, V. Fuster, J. J. Badimon, and J. H. Chesebro Acute Antithrombotic Effect of a Front-Loaded Regimen of Clopidogrel in Patients With Atherosclerosis on Aspirin Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2316 - 2321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Moshfegh, M. Redondo, F. Julmy, W. A. Wuillemin, M. U. Gebauer, A. Haeberli, and B. J. Meyer Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy J. Am. Coll. Cardiol., September 1, 2000; 36(3): 699 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
M. E. Bertrand, H.-J. Rupprecht, P. Urban, A. H. Gershlick, and f. t. C. Investigators Double-Blind Study of the Safety of Clopidogrel With and Without a Loading Dose in Combination With Aspirin Compared With Ticlopidine in Combination With Aspirin After Coronary Stenting : The Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS) Circulation, August 8, 2000; 102(6): 624 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cadroy, J.-P. Bossavy, C. Thalamas, L. Sagnard, K. Sakariassen, and B. Boneu Early Potent Antithrombotic Effect With Combined Aspirin and a Loading Dose of Clopidogrel on Experimental Arterial Thrombogenesis in Humans Circulation, June 20, 2000; 101(24): 2823 - 2828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 M. Verstraete, C. R. M. Prentice, M. Samama, and R. Verhaeghe A European View on the North American Fifth Consensus on Antithrombotic Therapy Chest, June 1, 2000; 117(6): 1755 - 1770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 A. Brodison, R. Katira, R. S More, and A. Chauhan Current practice: Antiplatelet use in interventional cardiology Postgrad. Med. J., February 1, 2000; 76(892): 70 - 79. [Abstract] [Full Text]
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|
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|
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P. B. Berger, M. R. Bell, C. S. Rihal, H. Ting, G. Barsness, K. Garratt, V. Bellot, V. Mathew, S. Melby, L. Hammes, et al. Clopidogrel versus ticlopidine after intracoronary stent placement J. Am. Coll. Cardiol., December 1, 1999; 34(7): 1891 - 1894. [Abstract] [Full Text] [PDF]
|
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M. J. Quinn and D. J. Fitzgerald Ticlopidine and Clopidogrel Circulation, October 12, 1999; 100(15): 1667 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
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A. Brodison, R. S More, and A. Chauhan Stents in medicine: The role of coronary angioplasty and stenting in acute myocardial infarction Postgrad. Med. J., October 1, 1999; 75(888): 591 - 598. [Abstract] [Full Text]
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