From the Program in Molecular and Cellular Cardiology, Departments of
Medicine and Otolaryngology, Harper Hospital, Detroit, Mich; the VA Medical
Center, Boston University Medical Center, Boston, Mass (J.K.G.); and the
Arrhythmia Center/Sinai Hospital (M.H.L.) and Wayne State University School of
Medicine, Detroit, Mich (J.D.M.).
Correspondence to James D. Marsh, MD, Wayne State University School of Medicine, 421 E Canfield Ave, Detroit, MI 48201. E-mail marsh{at}cardiology.harper.wayne.edu
Background—The role of androgens in
producing cardiac hypertrophy by direct action on cardiac
myocytes is uncertain. Accordingly, we tested the hypothesis that
cardiac myocytes in adult men and women express an androgen receptor
gene and that myocytes respond to androgens by a hypertrophic
response.
Methods and Results—We used reverse transcription–polymerase
chain reaction methods to demonstrate androgen receptor transcripts in
multiple tissues and [3H]phenylalanine incorporation and
atrial natriuretic peptide secretion as markers of
hypertrophy in cultured rat myocytes. Messenger RNA
encoding androgen receptors was detected in myocytes of male and female
adult rats, neonatal rat myocytes, rat heart, dog heart, and infant and
adult human heart. Both testosterone and dihydrotestosterone produced a
robust receptor-specific hypertrophic response in myocytes, determined
by indices of protein synthesis and atrial natriuretic
peptide secretion.
Conclusions—Androgen receptors are present in cardiac
myocytes from multiple species, including normal men and women, in a
context that permits androgens to modulate the cardiac
phenotype and produce hypertrophy by direct,
receptor-specific mechanisms. There are clinical implications for
therapeutic or illicit use of androgens in humans.
© 1998 American Heart Association, Inc.
Basic Science Reports
Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes
Key Words: hormones • hypertrophy • myocytes
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