(Circulation. 1999;99:26-29.)
© 1999 American Heart Association, Inc.
Brief Rapid Communication |
Percutaneous Transluminal Therapy of Occluded Saphenous Vein Grafts
Can the Challenge Be Met With Ultrasound Thrombolysis?
From the Tel Aviv Sourasky Medical Center (U.R., S.L., H.I.M.), Tel Aviv, Israel; Hanusch KH (G. Gaul), Vienna, Austria; Universitatsklinikum Essen (R.E.), Essen, Germany; Universitaatsspital Zurich (F.A.), Zurich, Switzerland; Medellin Clinic (D.V.), Medellin, Colombia; Herzzentrum Frankfurt (H.S.), Frankfurt, Germany; Uni Kiel (R.S.), Kiel, Germany; Shaio Clinic (G. Gomez), Bogata, Colombia; Stadt Klinikum Oldenburg (J.T.), Oldenburg, Germany; Centro Cardiologico Milan (A.B.), Milan, Italy; Herzzentrum Bodensee (M.P.), Kreuzlingen, Switzerland; Onassis Cardiac Surgery Center (Z.K.), Athens, Greece; Hospital Charles Nicolle, Rouen, France; and Clinique Pasteur (J.F.), Toulouse, France.
Correspondence to Uri Rosenschein, MD, Catheterization Laboratory, Department of Cardiology, The Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv 64239, Israel. E-mail urosenschein{at}angiosonics.co.il
Background—Percutaneous transluminal treatment of a thrombotic vein graft yields poor results. We have previously reported our experience with transluminal percutaneous coronary ultrasound thrombolysis (CUT) in the setting of acute myocardial infarction (AMI). This report describes the first experience with ultrasound thrombolysis in thrombus-rich lesions in saphenous vein grafts (SVGs), most of which were occluded.
Methods and Results—The patients (n=20) were mostly male
(85%), aged 64±4 years old. The presenting symptom was AMI in 2
patients (10%) and unstable angina in the rest. Fifteen patients
(75%) had totally occluded SVGs. The median age of clots was 6 days
(range, 0 to 100 days). The ultrasound thrombolysis
device has a 1.6-mm-long tip and fits into a 7F guiding catheter over a
0.014-in guidewire in a "rapid-exchange" system. CUT (41 kHz, 18 W,
6 minutes) led to device success in 14 (70%) of the patients
and residual stenosis of 65±28%. Procedural success was
obtained in 13 (65%) of the patients, with a final residual
stenosis of 5±8%. There was a low rate of device-related
adverse events: 1 patient (5%) had a non–Q-wave myocardial
infarction, and distal embolization was noted in 1 patient (5%).
Adjunct PTCA or stenting was used in all patients. There were no
serious adverse events during hospitalization.
Conclusions—Ultrasound thrombolysis in thrombus-rich lesions in SVGs offers a very promising therapeutic option.
Key Words: thrombolysis • ultrasonics • grafting • occlusion • bypass
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