(Circulation. 1999;99:2070-2072.)
© 1999 American Heart Association, Inc.
Brief Rapid Communication |
Hyperhomocysteinemia
A Risk Factor for Ischemic Stroke in Children
From University Hospital Nijmegen, The Netherlands, Department of Pediatrics (I.M.v.B., J.A.M.S., M.T.W.B.t.P.P., H.J.B.) and Department of Internal Medicine (M.d.H.).
Correspondence to Dr Henk J. Blom, Department of Pediatrics, University Hospital Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. E-mail h.blom{at}ckslkn.azn.nl
Background—Moderate hyperhomocysteinemia is a risk factor for arterial vascular disease and venous thrombosis in adults. We performed a case-control study to assess a possible relation between moderate hyperhomocysteinemia and ischemic stroke in Dutch children (age range, 0 to 18 years).
Methods and Results—We measured plasma total homocysteine levels (tHcy) in 45 patients with ischemic stroke and in 234 controls. Hyperhomocysteinemia was defined as a tHcy above the 95th percentile regression line for the respective age of the controls. Hyperhomocysteinemia was present in 8 (18%) of the 45 patients with ischemic stroke. The odds ratio was 4.4 (95% CI, 1.7 to 11.6).
Conclusions—We conclude that moderate hyperhomocysteinemia is a risk factor for ischemic stroke in children.
Key Words: hyperhomocysteinemia • cerebral infarction • stroke • pediatrics
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