(Circulation. 1999;99:1161-1164.)
© 1999 American Heart Association, Inc.
Clinical Investigation and Reports |
Prospective Study of Chlamydia pneumoniae IgG Seropositivity and Risks of Future Myocardial Infarction
From the Divisions of Cardiology (P.M.R.), Preventive Medicine (P.M.R., C.H.H.), Channing Laboratory (M.J.S.), and Microbiology (R.K., S.P.), Department of Medicine, Brigham and Womens' Hospital, Harvard Medical School, Boston, Mass.
Correspondence to Dr Paul M. Ridker, Brigham and Womens' Hospital, 75 Francis St, Boston, MA 02115. E-mail pmridker{at}bics.bwh.harvard.edu
Background—Chlamydia pneumoniae has been hypothesized to play a role in atherothrombosis. However, prospective data relating exposure to Chlamydia pneumoniae and risks of future myocardial infarction (MI) are sparse.
Methods and Results—In a prospective cohort of nearly 15 000
healthy men, we measured IgG antibodies directed against
Chlamydia pneumoniae in blood samples collected at
baseline from 343 study participants who subsequently reported a first
MI and from an equal number of age- and smoking-matched control
subjects who did not report vascular disease during a 12-year follow-up
period. The proportion of study subjects with IgG antibodies directed
against Chlamydia increased with age and cigarette
consumption. However, prevalence rates of Chlamydia IgG
seropositivity were virtually identical at baseline among men who
subsequently reported first MI compared with age- and smoking-matched
control subjects. Specifically, the relative risks of future MI
associated with Chlamydia pneumoniae IgG titers 
1:16,
1:32, 1:64, 1:128, and 1:256 were 1.1, 1.0, 1.1, 1.0, and 0.8,
respectively (all probability values not significant). There was no
association in analyses adjusted for other risk factors,
evaluating early as compared with late events, or among nonsmokers.
Further, there was no association between seropositivity and
concentration of C-reactive protein, a marker of inflammation that
predicts MI risk in this cohort.
Conclusions—In a large-scale study of socioeconomically homogeneous men that controlled for age, smoking, and other cardiovascular risk factors, we found no evidence of association between Chlamydia pneumoniae IgG seropositivity and risks of future MI.
Key Words: antibodies • myocardial infarction • proteins • risk factors • atherosclerosis
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