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(Circulation. 2000;101:e226.)
© 2000 American Heart Association, Inc.

Circulation Electronic Pages

Impending Paradoxical Embolism

Tsung O. Cheng, MD

George Washington University Washington, DC 20037

	Introduction

 
To the Editor:

The echocardiogram on the cover of the June 1, 1999, issue of Circulation is a beautiful illustration of an impending paradoxical embolism. Unfortunately, neither the text¹ nor the key words of the article made any mention of this condition.

Impending paradoxical embolism² is a surgical emergency. This diagnosis would not have been possible before the advent of echocardiography. However, to diagnose paradoxical embolism, contrast echocardiography should be performed during and after a Valsalva maneuver.³ The mere establishment of the presence of a patent foramen ovale by either transthoracic or transesophageal echocardiography does not diagnose paradoxical embolism.⁴

A patent foramen ovale is a frequent finding in normal subjects—27.3% in a large autopsy series.⁵ Normally, a positive left-to-right atrium pressure gradient exists and, therefore, no interatrial shunt exists in either direction. It is only during a Valsalva maneuver or any condition that raises right atrial pressure such as in acute pulmonary embolism that a right-to-left shunt across the patent foramen ovale may result. That is the reason why, when requesting an echocardiogram to "rule out cardiogenic origin of systemic embolism," one should specifically mention paradoxical embolism, which would not be detected by routine echocardiography without the use of contrast and the Valsalva maneuver.³

	References

 
1. Chartier L, Béra J, Delomez M, et al. Free-floating thrombi in the right heart: diagnosis, management, and prognostic indexes in 38 consecutive patients. Circulation. 1999;99;2779–2783.

2. Cheng TO. Impending paradoxical embolism: a transesophageal echocardiographic image. Clin Cardiol. 1999;22:328.[Medline] [Order article via Infotrieve]

3. Cheng TO. Echocardiography and paradoxical embolism. Ann Intern Med. 1981;95:515.

4. Cheng TO. Paradoxical embolism: a diagnostic challenge and its detection during life. Circulation. 1976;53:565–568.

5. Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc. 1984;59:17–20.[Medline] [Order article via Infotrieve]

Response

Ludovic Chartier, MD; Jérôme Béra, MD; Maxence Delomez, MD; Philippe Asseman, MD; Jean-Paul Beregi, MD; Jean-Jacques Bauchart, MD; Henri Warrembourg, MD; Claude Théry, MD

Hôpital Cardiologique, Lille, France

	Introduction

 
We thank Dr Cheng for his interest in our article.^R1 As he points out, the figure illustrates an impending paradoxical embolism. We agree that echocardiography is extremely helpful in the investigation of cerebral and peripheral embolic events.^R2 A transthoracic approach may be sufficient in some cases, . . . [Full Text of this Article]

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