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(Circulation. 2000;101:e92.)
© 2000 American Heart Association, Inc.

Circulation Electronic Pages

Dynamic Magnetic Resonance Images of Murine Cardiac Function at Physiologic Heart Rates

Robert G. Weiss, MD; Sonia M. Chacko, MS; Francesca Aresta, MD; V. P. Chacko, PhD

From the Departments of Medicine (R.G.W., S.M.C., F.A.) and Radiology (V.P.C.), The Johns Hopkins University School of Medicine, Baltimore, Md.

Correspondence to Robert G. Weiss, MD, Department of Medicine, Cardiology Division, Carnegie 584, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21287-6568. E-mail rgweiss@rad.jhu.edu

	Introduction

 
Cine cardiac magnetic resonance images of intact, adult mice at a heart rate of 550 beats/min (>9 beats/s) were acquired at 4.7 T during light isoflurane-inhaled sedation. Figure 1 shows spin-echo magnetic resonance images (repetition time, 600 ms; echo time, 11 ms; 2-mm slice thickness; matrix of 256x256, yielding in-plane pixel resolution of 0.125 mm) that were obtained every 10 ms throughout the cardiac cycle and were from a short axis slice. A sphere, located outside the chest and measuring 3.5 mm in diameter, is shown for reference. A comparable cine loop from a left ventricular long-axis slice (right ventricle is on the left, left ventricle on the right) is displayed in Figure 2. Mice awakened within 1 minute of the completion of the study. These high-resolution, noninvasive images provide anatomic detail, excellent contrast between the right and left ventricular walls and the intracavitary blood, and dynamic functional information in intact mice at physiological heart rates.

	Footnotes

 
The editor of Images in Cardiovascular Medicine is Hugh A. McAllister, Jr, MD, Chief, Department of Pathology, St Luke’s Episcopal Hospital and Texas Heart Institute, and Clinical Professor of Pathology, University of Texas Medical School and Baylor College of Medicine.

Circulation encourages readers to submit cardiovascular images to Dr Hugh A. McAllister, Jr, St Luke’s Episcopal Hospital and Texas Heart Institute, 6720 Bertner Ave, MC1-267, Houston, TX 77030.

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