This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Taylor, D. A. Articles by Goldschmidt-Clermont, P. J. Search for Related Content PubMed PubMed Citation Articles by Taylor, D. A. Articles by Goldschmidt-Clermont, P. J. Related Collections Structure Congestive Physiological and pathological control of gene expression Other Treatment CV surgery: transplantation, ventricular assistance, cardiomyopathy

(Circulation. 2002;106:2.)
© 2002 American Heart Association, Inc.

Editorial

Cardiac Chimerism as a Mechanism for Self-Repair

Does It Happen and If So to What Degree?

Doris A. Taylor, PhD; Ralph Hruban, MD; E.Rene Rodriguez, MD; Pascal J. Goldschmidt-Clermont, MD

From the Division of Cardiology (D.A.T., P.J.G.) Duke University Medical Center, Durham, NC; and the Department of Pathology (R.H., E.R.R.), Johns Hopkins University School of Medicine, Baltimore, Md.

Correspondence to Doris A. Taylor, PhD, Associate Professor, Division of Cardiology, Box 3345 DUMC, Duke University Medical Center, Durham, NC 27710. E-mail dataylor@duke.edu

Key Words: Editorials • myocytes • transplantation • regeneration • cells

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Cardiac regeneration is an area that has gained considerable attention lately, especially with the finding that immature muscle cells and/or autologous stem cells can regenerate function in a previously injured heart.^1,2,3 However, this fertile field remains unsettled enough that each piece of new data should be rigorously scrutinized. Toward that end, a controversy has arisen recently concerning the potential for cardiovascular self-repair evidenced by chimerism in an allografted human heart. Several investigators have allografted female hearts into human male recipients and examined the heart at the time of explantation for the presence of Y chromosome–positive cells either in the coronary vasculature or within cardiomyocytes.^4–7 Conflicting results have been obtained. The report by Glaser et al⁴ in this issue of Circulation presents one side of the controversy, namely that regeneration is possible to a certain degree in the coronary vasculature but fails to occur within cardiomyocytes.⁴ In contrast, the recent report by Quaini et al⁵ claimed not only that vascular regeneration occurs, but also that repair of up to 30% of the donor myocardium takes place within 1 month of transplantation.

See p 17

The notion of progenitor cell–based vascular repair arises naturally from our understanding of vascular biology, where endothelial and smooth muscle cell turnover and replacement are clinically accepted. In fact, the use of endothelial progenitor cells to repair damaged vasculature is an exciting new area of investigation.⁸

In contrast, the controversy over myocardial chimerism and repair is one that requires a paradigm shift from the accepted dogma of . . . [Full Text of this Article]

This article has been cited by other articles:

				D. C. Vela, G. V. Silva, J. A.R. Assad, A. L.S. Sousa, S. Coulter, M. R. Fernandes, E. C. Perin, J. T. Willerson, and L. M. Buja Histopathological Study of Healing After Allogenic Mesenchymal Stem Cell Delivery in Myocardial Infarction in Dogs J. Histochem. Cytochem., February 1, 2009; 57(2): 167 - 176. [Abstract] [Full Text] [PDF]

				K. Naito, T. Anzai, Y. Sugano, Y. Maekawa, T. Kohno, T. Yoshikawa, K. Matsuno, and S. Ogawa Differential Effects of GM-CSF and G-CSF on Infiltration of Dendritic Cells during Early Left Ventricular Remodeling after Myocardial Infarction J. Immunol., October 15, 2008; 181(8): 5691 - 5701. [Abstract] [Full Text] [PDF]

				C. Baigent and R. Clarke B Vitamins for the Prevention of Vascular Disease: Insufficient Evidence to Justify Treatment JAMA, September 12, 2007; 298(10): 1212 - 1214. [Full Text] [PDF]

				R. Haris Naseem, A. P. Meeson, J. Michael DiMaio, M. D. White, J. Kallhoff, C. Humphries, S. C. Goetsch, L. J. De Windt, M. A. Williams, M. G. Garry, et al. Reparative myocardial mechanisms in adult C57BL/6 and MRL mice following injury Physiol Genomics, June 19, 2007; 30(1): 44 - 52. [Abstract] [Full Text] [PDF]

				P. Anversa, A. Leri, and J. Kajstura Cardiac Regeneration J. Am. Coll. Cardiol., May 2, 2006; 47(9): 1769 - 1776. [Abstract] [Full Text] [PDF]

				P. Anversa, J. Kajstura, A. Leri, and R. Bolli Life and Death of Cardiac Stem Cells: A Paradigm Shift in Cardiac Biology Circulation, March 21, 2006; 113(11): 1451 - 1463. [Full Text] [PDF]

				A. Leri, J. Kajstura, and P. Anversa Cardiac Stem Cells and Mechanisms of Myocardial Regeneration Physiol Rev, October 1, 2005; 85(4): 1373 - 1416. [Abstract] [Full Text] [PDF]

				M. H. Yamani, N. B. Ratliff, D. J. Cook, E. M. Tuzcu, Y. Yu, R. Hobbs, G. Rincon, C. Bott-Silverman, J. B. Young, N. Smedira, et al. Peritransplant Ischemic Injury Is Associated With Up-Regulation of Stromal Cell-Derived Factor-1 J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1029 - 1035. [Abstract] [Full Text] [PDF]

				J. C Chachques, C. Salanson-Lajos, P. Lajos, A. Shafy, A. Alshamry, and A. Carpentier Cellular Cardiomyoplasty for Myocardial Regeneration Asian Cardiovasc Thorac Ann, September 1, 2005; 13(3): 287 - 296. [Abstract] [Full Text] [PDF]

				M. F. Pittenger and B. J. Martin Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics Circ. Res., July 9, 2004; 95(1): 9 - 20. [Abstract] [Full Text] [PDF]

				S. Minatoguchi, G. Takemura, X.-H. Chen, N. Wang, Y. Uno, M. Koda, M. Arai, Y. Misao, C. Lu, K. Suzuki, et al. Acceleration of the Healing Process and Myocardial Regeneration May Be Important as a Mechanism of Improvement of Cardiac Function and Remodeling by Postinfarction Granulocyte Colony-Stimulating Factor Treatment Circulation, June 1, 2004; 109(21): 2572 - 2580. [Abstract] [Full Text] [PDF]

				L. G. Melo, A. S. Pachori, D. Kong, M. Gnecchi, K. Wang, R. E. Pratt, and V. J. Dzau Molecular and Cell-Based Therapies for Protection, Rescue, and Repair of Ischemic Myocardium: Reasons for Cautious Optimism Circulation, May 25, 2004; 109(20): 2386 - 2393. [Full Text] [PDF]

				L. G. MELO, A. S. PACHORI, D. KONG, M. GNECCHI, K. WANG, R. E. PRATT, and V. J. DZAU Gene and cell-based therapies for heart disease FASEB J, April 1, 2004; 18(6): 648 - 663. [Abstract] [Full Text] [PDF]

				J. C. Chachques, C. Acar, J. Herreros, J. C. Trainini, F. Prosper, N. D'Attellis, J.-N. Fabiani, and A. F. Carpentier Cellular cardiomyoplasty: clinical application Ann. Thorac. Surg., March 1, 2004; 77(3): 1121 - 1130. [Abstract] [Full Text] [PDF]

				K. Urbanek, F. Quaini, G. Tasca, D. Torella, C. Castaldo, B. Nadal-Ginard, A. Leri, J. Kajstura, E. Quaini, and P. Anversa From The Cover: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy PNAS, September 2, 2003; 100(18): 10440 - 10445. [Abstract] [Full Text] [PDF]

				H. M. Kvasnicka, C. Wickenhauser, J. Thiele, A. Deb, S. Wang, K. A. Skelding, D. Miller, D. Simper, and N. M. Caplice Quantifying Chimeric Cardiomyocytes * Response Circulation, August 26, 2003; 108 (8): e60 - e60. [Full Text] [PDF]

				M. Korbling and Z. Estrov Adult Stem Cells for Tissue Repair -- A New Therapeutic Concept? N. Engl. J. Med., August 7, 2003; 349(6): 570 - 582. [Full Text] [PDF]

				A. Liem, G. H. Reynierse-Buitenwerf, A. H. Zwinderman, J. W. Jukema, and D. J. van Veldhuisen Secondary prevention with folic acid: effects on clinical outcomes J. Am. Coll. Cardiol., June 18, 2003; 41(12): 2105 - 2113. [Abstract] [Full Text] [PDF]

				A. C. Fijnvandraat, R. H. Lekanne Deprez, and A. F.M. Moorman Development of heart muscle-cell diversity: a help or a hindrance for phenotyping embryonic stem cell-derived cardiomyocytes Cardiovasc Res, May 1, 2003; 58(2): 303 - 312. [Abstract] [Full Text] [PDF]

				P. Muller, M. Bohm, D. A. Taylor, R. Hruban, E. R. Rodriguez, and P. Goldschmidt-Clermont Chimerism as a Mechanism of Self-Repair * Response Circulation, March 11, 2003; 107 (9): e69 - e69. [Full Text] [PDF]

				A. Deb, S. Wang, K. A. Skelding, D. Miller, D. Simper, and N. M. Caplice Bone Marrow-Derived Cardiomyocytes Are Present in Adult Human Heart: A Study of Gender-Mismatched Bone Marrow Transplantation Patients Circulation, March 11, 2003; 107(9): 1247 - 1249. [Abstract] [Full Text] [PDF]

				B. E. Strauer and R. Kornowski Stem Cell Therapy in Perspective Circulation, February 25, 2003; 107(7): 929 - 934. [Full Text] [PDF]

				N. M. Caplice and B. J. Gersh Stem Cells to Repair the Heart: A Clinical Perspective Circ. Res., January 10, 2003; 92(1): 6 - 8. [Full Text] [PDF]

				H. Sauer, J. Hescheler, and M. Wartenberg Cardiac differentiation of mesenchymal stem cells in sex mis-matched transplanted hearts: self-repair or just a visit? Cardiovasc Res, December 1, 2002; 56(3): 357 - 358. [Full Text] [PDF]

				P. Anversa, B. Nadal-Ginard, D. A. Taylor, P. J. Goldschmidt, R. Hruban, and E. R. Rodriguez Cardiac Chimerism: Methods Matter * Response Circulation, October 29, 2002; 106 (18): e129 - e131. [Full Text] [PDF]