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(Circulation. 2002;106:e9037.)
© 2002 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Increases in Urinary Albumin Excretion Predict Risk of Death From All Cases as Well as Those From Cardiovascular Disease

Urinary excretion of albumin predicts an increased risk of all-cause mortality, particularly cardiovascular mortality, according to researchers led by Hans L. Hillege, MD, of the Department of Cardiology at the University Hospital in Groningen, the Netherlands, in a report in this week’s issue of Circulation (Circulation. 2002;106:1777–1782).

In this study by the Prevention of REnal and Vascular ENd stage Disease (PREVEND) group, questionnaires about cardiovascular disease and cardiovascular morbidity, along with a vial to collect an early morning urine sample, were sent to 85 421 inhabitants of Groningen, the Netherlands, between 1997 and 1998. Of those contacted, 40 856 responded and 40 548 were included in the analysis. The urine was used to collect a measurement of urinary albumin concentration.

Later, researchers determined whether the subjects were alive by checking the municipal register. Cause of death was obtained from the Central Bureau of Statistics. During a follow-up period that averaged 961 days, 516 deaths of known cause were recorded for the cohort.

Researchers found a positive dose-response relationship between urinary albumin concentration and mortality. Higher urinary albumin concentration results increased the risk of both cardiovascular and noncardiovascular death after adjustment for other known cardiovascular risk factors. The increases were significantly higher for cardiovascular mortality than for other causes of death. A doubled concentration of urinary albumin was associated with a 1.29 relative risk of cardiovascular mortality and a 1.12 relative risk of death from other causes.

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