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(Circulation. 2002;106:e9051.)
© 2002 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Impaired Autonomic Regulation Points to Cardiovascular Risk

When patients have a blood pressure at the high end of normal, they already carry a risk of cardiovascular disease that exceeds that of normal people. In a report in this week’s Circulation (Circulation. 2002;106:2673–2679), researchers led by Daniela Lucini, MD, PhD, of the Centro di Ricerca sulla Terapia Neurovegativa in Milano, Italy, found that there were already significant alterations in markers of autonomic regulations in individuals whose blood pressures were at the high end of normal.

The researchers performed an observational study on 300 subjects of both sexes with blood pressures that ranged from 90/60 mm Hg to 210/120 mm Hg. They were divided into 3 groups with average systolic pressures of 103, 133, and 163 mm Hg. Autonomic regulation was determined by analysis of the RR interval and systolic arterial pressure variability. Their studies uncovered significant alterations in markers of such regulation already apparent in individuals in the higher regions of blood pressure.

Aortic Valve Replacement in Patients With Regurgitation and Reduced Ejection Fraction
Aortic valve replacement in patients with severely reduced left ventricular ejection fraction results in higher operative mortality than in those with moderate reduction in or normal ejection fractions as well as increased rates of postoperative mortality and congestive heart failure. In this week’s issue of Circulation (Circulation. 2002;106:2687–2693), however, Han P. Chaliki, MD, of the Mayo Clinic in Rochester, Minn, and colleagues determined that the improvement in left ventricular ejection fraction and long postoperative survival without recurrence of heart failure means that they should not be denied the surgery.

C-Reactive Protein Is a Better Marker of Cardiovascular Risk Than Low-Density Lipoprotein
Measurements of . . . [Full Text of this Article]