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(Circulation. 2002;106:e9052.)
© 2002 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

This Week in Circulation

Patients with blood containing high levels of antibodies to heat shock protein 65 (hsp65) were found to be at increased risk of subsequent cardiovascular events, independent of other cardiovascular risk factors and inflammatory markers, according to researchers from Semmelweis University and the Hungarian Academy of Sciences in Budapest, Hungary, and McMaster University in Hamilton, Ontario, Canada, in a study appearing in this week’s issue of Circulation (Circulation. 2002;106:2775–2880).

In this study led by Amarilla Veres, MD, from Semmelweis University, researchers used blood samples from the Heart Outcomes Prevention Evaluation (HOPE) study and conducted a nested case control study of 386 people with cardiovascular events and compared them with 386 age- and sex-matched controls from the same study. They attempted to determine the relationship between heat shock protein antibodies, anti-cholesterol antibodies, and the incidence of myocardial infarction, stroke, and cardiovascular death during a 4.5-year follow-up. High levels of anti-hsp65 antibodies were found to be predictive of cardiovascular events with an odds ratio of 2 to 1. High levels of anti-cholesterol antibodies appeared to be protective of stroke in this report.

The authors concluded, "Measurement of anti-hsp65 antibodies may improve the prediction of future CV [cardiovascular] events in secondary prevention studies and provide additional insight into the role of heat shock protein in human atherosclerosis."

American Heart Association Celebrates 75th Anniversary of Scientific Sessions in Windy City
Chicago, Ill—An unexpected flurry of snow greeted the more than 30 000 attendees at the opening day of the 75th Scientific Sessions of the American Heart Association on November 17, 2002, but the snow dissipated . . . [Full Text of this Article]