doi: 10.1161/01.CIR.0000030720.29247.9F
(Circulation. 2002;106:893.)
© 2002 American Heart Association, Inc.
Editorial |
Cardiovascular Disease and Insulin-Like Growth Factor I
From the Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark.
Correspondence to Professor Hans Ørskov, Medical Research Laboratories, Aarhus Kommunehospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark. E-mail hans.orskov@afdm.au.dk
Key Words: Editorials • cardiovascular diseases • atherosclerosis • diabetes mellitus • growth substances
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
The research field of cardiovascular disease in regard to growth hormone (GH) and its mitogenic mediator insulin-like growth factor I (IGF-I) has a long and distinguished history and is still intensively studied. Medline searches reveal that more than 1000 articles have appeared, demonstrating the importance of IGF-I in development of (and for lesions in) the vascular system. Still, mechanisms are insufficiently elucidated. This is obviously partly due to the complexity of the system with formation of IGF-I and its 6 binding proteins (IGFBPs), not only in the liver but also in almost all other organs (including smooth muscle cells), inducing autocrine/paracrine effects via the ubiquitous IGF-I receptor (including vascular endothelium). More than 80% of circulating IGF-I derives from the liver and acts as a true hormone: 99% bound to IGFBPs and 1% in free form, easily transgressing the capillaries.
See p 939
Studies in animals and cell cultures allow for examination of changes in expression of IGF-I and IGFBPs at the site of action, whereas clinical studies like that of Juul et al1 in this issue of Circulation are restricted to analyses of the blood-borne IGF-I system. The overwhelming majority of previous studies point to IGF-I being a mediator of atherosclerotic processes and diabetic vascular lesions. However, during the last 4 years studies have lent support to Juul et al’s results and so indicated that a low serum IGF-I (and high IGFBP-3) is a risk marker for ischemic heart disease (IHD). This is exactly the opposite scenario of that proposed
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