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(Circulation. 2003;108:e9049.)
© 2003 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Inflammatory Markers=High Risk

High levels of C-reactive protein, interleukin-6, and tumor necrosis factor were strongly associated with the incidence of cardiovascular events in elderly patients who had no evidence of heart disease at study enrollment, said researchers in a report in this week’s issue of the journal Circulation ( Circulation. 2003;108:2317–2322[Abstract/Free Full Text]).

A total of 2225 subjects aged 70 to 79 years without baseline heart disease enrolled in the Health, Aging, and Body Composition study. They were followed up for an average of 3.6 years for coronary heart disease, stroke, and congestive heart failure. Interleukin-6 was associated significantly with all outcomes. Tumor necrosis factor was significantly associated with coronary heart disease, and C-reactive protein was associated with congestive heart failure events. If all three inflammatory markers were found to be in the highest tertile, the risk was especially high, said the researchers, led by Matteo Cesari, MD, of Wake Forest University School of Medicine, Winston Salem, NC.

Hypertrophic Cardiomyopathy Plus Coronary Artery Disease a Bad Mix
Patients with hypertrophic cardiomyopathy and concomitant severe coronary artery disease are at an increased risk of death, said researchers from the Mayo Clinic and Mayo Foundation in Rochester, Minn, in a report in this week’s issue of the journal Circulation ( Circulation. 2003;108:2342–2348[Abstract/Free Full Text]).

The researchers enrolled 433 adult patients with hypertrophic cardiomyopathy who also had severe coronary artery disease. All were over the age of 21 years, had a left ventricular ejection fraction of less than 50%, and had no prior history of surgical revascularization. Compared with patients who had mild or moderate . . . [Full Text of this Article]