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(Circulation. 2004;109:e9041-e9042.)
© 2004 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Everolimus Stent Proves Effective

The use of an everolimus-eluting stent proved effective in a study involving 42 patients, said investigators involved in the FUTURE I (First Use To Underscore restenosis Reduction with Everolimus) trial in a report in this week’s edition of the journal Circulation (Circulation. 2004;109:2168–2171).

Everolimus is similar to the first effective drug used in a stent—sirolimus. It too actively suppresses the immune system and proliferation. In this study, 42 patients with new coronary lesions were enrolled to receive either the everolimus-eluting stent (27) or a bare metal stent (15). At 30 days and at 6 months, the investigators, led by Eberhard Grube, MD, of the Heart Center Siegburg in Germany, found low rates of major adverse cardiac events. Between 6 and 12 months, no additional reports of major adverse cardiac events occurred. At 6 months, the rate of in-stent restenosis was 0% in the drug-eluting stent group, compared with 9.1% in the bare metal stent group. One patient in the bare metal stent group had an in-stent restenosis. The in-segment restenosis rates were 4% in the drug-eluting stent group and 9.1% in the bare metal stent group.

In this early clinical study, the researchers found that the everolimus-eluting stent was both safe and effective in reducing in-stent neointimal hyperplasia and restenosis.

Blood Pressure in the Young Growing
Blood pressure among children and adolescents in the United States has increased in the past decade, and researchers reporting in the May 5, 2004, issue of the Journal of the American Medical Association believe that increasing overweight . . . [Full Text of this Article]