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(Circulation. 2004;109:e9010-e9011.)
© 2004 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Metabolic Syndrome a Major Predictor of Heart Disease

The metabolic syndrome is a better predictor of cardiovascular risk in women than the popularized body mass index, said researchers for the multicenter Women’s Ischemia Syndrome Evaluation (WISE) study that appears in this week’s issue of the journal Circulation (Circulation 2004;109:706–713).

When women have myocardial ischemia, metabolic syndrome is a good indicator of grave cardiovascular risk, whereas body mass index does not appear to have a significant role in such predictions, said Steven Reis, MD, Associate Professor of Medicine at the University of Pittsburgh School of Medicine. Dr Reis is senior author of the study.

A total of 780 women, ages 21 to 86 years, were enrolled in the study. Researchers determined their metabolic syndrome status and referred them for coronary angiography to determine if they had myocardial ischemia. Their baseline evaluations included demographic factors, risk for coronary artery disease, regular medicine use, medical history, physical examinations, and a sample of blood taken after fasting. The blood was evaluated for lipids, glucose, insulin, presence of reproductive hormones, and inflammatory factors.

They were monitored an average of 3.5 years. A total of 41 women in the study died. In the women who had diabetes and metabolic syndrome, those who were normal weight had a 3.1-times higher adjusted odds of having significant coronary disease. Those who were overweight had 2.6-times higher odds, and those who were obese had 1.9-times higher odds. The 3-year survival rate was 97.2% in the women with normal metabolic status, compared with 91.5% for women with metabolic . . . [Full Text of this Article]