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(Circulation. 2004;110:1.)
© 2004 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

LOCAL GENE TRANSFER OF phVEGF-2 PLASMID BY GENE-ELUTING STENTS: AN ALTERNATIVE STRATEGY FOR INHIBITION OF RESTENOSIS, by Walter et al.

Currently approved drug-eluting stents are designed to inhibit vascular smooth muscle proliferation and, thereby, prevent restenosis. A major limitation of this approach is that the antiproliferative agents used also impair endothelial function and proliferation, which may, in part, account for late in-stent thrombosis. In a study of hypercholesterolemic rabbits, Walter and colleagues show that stents designed to release a plasmid containing the cDNA for vascular endothelial growth factor-2 accelerate reendothelialization and improve lumen cross-sectional area when compared with control stents. These preliminary results offer a novel, promising approach to ideal stent-based therapy. See p 36.

BLOOD PRESSURE REACTIVITY TO PSYCHOLOGICAL STRESS PREDICTS HYPERTENSION IN THE CARDIA STUDY, by Matthews et al.

Early identification of individuals at risk for the development of hypertension could lead to earlier treatment and reduce cardiovascular risk. In a study of 4105 normotensive young adults, Matthews and colleagues report that an exaggerated blood pressure response to the cold pressor test or certain standardized forms of psychosocial stress predict the subsequent development of hypertension over 13 years. An increase in blood pressure is an expected physiological response, and it remains uncertain whether exaggerated responses relate to the pathogenesis of the disease. Nevertheless, these results raise the possibility that this type of stress test might be used to identify individuals at risk for hypertension, providing improved opportunities for primary prevention. See p 74.

ABDOMINAL AORTIC ANEURYSM EXPANSION: RISK FACTORS AND TIME INTERVALS FOR SURVEILLANCE, by Brady et al.

Abdominal aortic aneurysms (defined as an aortic diameter 30 mm) occurs in about 5% of men over the age of 50 years. The probability of expansion of an abdominal aortic aneurysm to >55 mm, a size where referral for . . . [Full Text of this Article]

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Abdominal Aortic Aneurysm Expansion: Risk Factors and Time Intervals for Surveillance

Anthony R. Brady, Simon G. Thompson, F. Gerald R. Fowkes, Roger M. Greenhalgh, Janet T. Powell on behalf of the UK Small Aneurysm Trial Participants
Circulation 2004 110: 16-21. [Abstract] [Full Text]

Local Gene Transfer of phVEGF-2 Plasmid by Gene-Eluting Stents: An Alternative Strategy for Inhibition of Restenosis

Dirk H. Walter, Manfred Cejna, Larry Diaz-Sandoval, Sean Willis, Laura Kirkwood, Peter W. Stratford, Anne B. Tietz, Rudolf Kirchmair, Marcy Silver, Cindy Curry, Andrea Wecker, Young-Sup Yoon, Regina Heidenreich, Allison Hanley, Marianne Kearney, Fermin O. Tio, Patrik Kuenzler, Jeffrey M. Isner, and Douglas W. Losordo
Circulation 2004 110: 36-45. [Abstract] [Full Text]

Blood Pressure Reactivity to Psychological Stress Predicts Hypertension in the CARDIA Study

Karen A. Matthews, Charles R. Katholi, Heather McCreath, Mary A. Whooley, David R. Williams, Sha Zhu, and Jerry H. Markovitz
Circulation 2004 110: 74-78. [Abstract] [Full Text]

Approach to "Aspirin Allergy" in Cardiovascular Patients

Srinivasan Ramanuja, Jeffrey A. Breall, and Vijay G. Kalaria
Circulation 2004 110: e1-e4. [Extract] [Full Text]

Vascular Healing 4 Years After the Implantation of Sirolimus-Eluting Stent in Humans: A Histopathological Examination

J. Eduardo Sousa, Marco A. Costa, Andrew Farb, Alexandre Abizaid, Amanda Sousa, Ana C. Seixas, Lilian M. da Silva, Fausto Feres, Ibraim Pinto, Luiz A. Mattos, and Renu Virmani
Circulation 2004 110: e5-e6. [Extract] [Full Text]

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