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(Circulation. 2005;111:1351.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	MOLECULAR MAGNETIC RESONANCE IMAGING OF CORONARY THROMBOSIS AND PULMONARY EMBOLI WITH A NOVEL FIBRIN-TARGETED CONTRAST AGENT, by Spuentrup et al.

 
Thrombus formation may be responsible for both coronary and pulmonary embolic disease; however, localizing thrombi in vivo is difficult. Imaging techniques that could differentiate the location of thrombus would be of utility for both diagnosis and prognosis. In this issue of Circulation, Spuentrup and colleagues utilize a novel fibrin-specific contrast agent in targeted magnetic resonance imaging to attempt to localize thrombi in an animal model. They report that this method can selectively localize thrombi in the heart, coronary arteries, and pulmonary vasculature. Although these are early animal studies, the potential for this technique to localize thrombus in vivo using magnetic resonance imaging has obvious clinical implications. See p 1377.

	SHORT- AND LONG-TERM CLINICAL OUTCOME AFTER DRUG-ELUTING STENT IMPLANTATION FOR THE PERCUTANEOUS TREATMENT OF LEFT MAIN CORONARY ARTERY DISEASE: INSIGHTS FROM THE RAPAMYCIN-ELUTING AND TAXUS STENT EVALUATED AT ROTTERDAM CARDIOLOGY HOSPITAL REGISTRIES (RESEARCH AND T-SEARCH), by Valgimigli et al.

 
Patients with high-risk lesions for percutaneous coronary intervention, such as a critical left main stenosis, are often referred for surgical revascularization because of patient- and lesion-specific characteristics as well as the potential for major adverse events with a percutaneous procedure. It has been demonstrated previously that stent placement in the left main coronary artery is feasible, and several series have reported on the safety and efficacy of this procedure in selected patient populations. Despite the success of this procedure, restenosis remains a serious and potentially fatal adverse event associated with this strategy. Although drug-eluting stents have reduced restenosis rates significantly, the experience with these stents in left main coronary artery percutaneous revascularization procedures has not been fully evaluated. In issue of Circulation, Valgimigli et al report on the short- and long-term outcomes of patients who underwent left main . . . [Full Text of this Article]

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