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(Circulation. 2005;111:2413.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	POSTINFARCTION GENE THERAPY AGAINST TRANSFORMING GROWTH FACTOR-ß SIGNAL MODULATES INFARCT TISSUE DYNAMICS AND ATTENUATES LEFT VENTRICULAR REMODELING AND HEART FAILURE, by Okada et al.

 

	REGENERATION OF INFARCTED MYOCARDIUM BY INTRAMYOCARDIAL IMPLANTATION OF EX VIVO TRANSFORMING GROWTH FACTOR-ß–PREPROGRAMMED BONE MARROW STEM CELLS, by Li et al.

 
The clinical benefit of limiting ventricular remodeling after myocardial infarction is clear, though the pharmacological tools we have available are only moderately successful. Future therapies targeting the underlying biology of the remodeling process appear promising, although as 2 articles in this week’s Circulation illustrate, ‘the devil is in the details.’ Tissue growth factor ß (TGF ß) promotes fibroblast proliferation and scar formation, and a study by Okada et al suggests that blocking its action in the heart will improve outcome after infarction. On the other hand, Li et al demonstrate that the same growth factor has a beneficial effect on bone marrow stem cells, improving their ability to differentiate into myocytes and repair the wounded heart. Careful evaluation of these and other biologically based therapeutic strategies have the potential to lead us to the next era in management of the postinfarction patient. See pp 2430 and 2438.

	LOWER SERUM SODIUM IS ASSOCIATED WITH INCREASED SHORT-TERM MORTALITY IN HOSPITALIZED PATIENTS WITH WORSENING HEART FAILURE: RESULTS FROM THE OUTCOMES OF A PROSPECTIVE TRIAL OF INTRAVENOUS MILRINONE FOR EXACERBATIONS OF CHRONIC HEART FAILURE (OPTIME-CHF) STUDY, by Klein et al.

 
Hyponatremia was identified years ago as a powerful predictor of an unfavorable prognosis in patients with heart failure, originally in patients with severe reduction in serum sodium. In this issue of Circulation, a retrospective analysis of 949 patients admitted to hospital with decompensated heart failure in the OPTIME-CHF trial by Klein and colleagues demonstrates that even modest degrees of reduction in serum sodium were associated with a significantly elevated risk of unfavorable outcomes, including number of days in hospital within 60 days of randomization, as well as in-hospital and 60-day mortality. Moreover, the results were seen in the setting of substantial . . . [Full Text of this Article]

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Lower Serum Sodium Is Associated With Increased Short-Term Mortality in Hospitalized Patients With Worsening Heart Failure: Results From the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Study

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