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(Circulation. 2005;111:119.)
© 2005 American Heart Association, Inc.
Issue Highlights
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
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CLINICAL PROGRESSION OF INCIDENTAL, ASYMPTOMATIC LESIONS DISCOVERED DURING CULPRIT VESSEL CORONARY INTERVENTION, by Glaser et al. |
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"To intervene or not to intervene" remains one of the outstanding questions for the interventional cardiologist when incidental nontarget lesions are identified during coronary angiography. Recent advances in vascular biology have contributed to our understanding of the vulnerable plaque and suggest that early intervention of these lesions may improve long-term outcomes. Furthermore, in the drug-eluting stent era, restenosis rates have declined to the single digits, and data now exist to demonstrate that these results remain durable over several years. In this issue of Circulation, Glaser et al provide the final piece of the puzzle: Data from the National Heart, Lung and Blood Institute Dynamic Registry are used to determine how many patients annually have progression of nontarget lesions resulting in clinical events. See p 143.
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MESENCHYMAL STEM CELLS DIFFERENTIATE INTO AN ENDOTHELIAL PHENOTYPE, ENHANCE VASCULAR DENSITY, AND IMPROVE HEART FUNCTION IN A CANINE CHRONIC ISCHEMIA MODEL, by Silva et al. |
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Bone marrow–derived stem cells have been carefully studied for use as potential regenerative therapy for myocardial infarction. Cell populations generally have been heterogeneous, and most studies have been performed in the setting of acute myocardial infarction or in the early post–myocardial infarction phase. In this issue, Silva and colleagues advance the field by isolating mesenchymal stem cells for intramyocardial injection, and use a canine model of chronic ischemia, representing hibernation and chronic ischemic cardiomyopathy. They report that the cell therapy reversed the progressive decline in left ventricular function at rest and during stress, and that the cells differentiated into smooth muscle cells and endothelial cells rather than myocytes, resulting in increased vascularity. These data advance our understanding of the fate of injected stem
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