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(Circulation. 2005;111:245.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	PATIENTS WITH DEPRESSIVE SYMPTOMS HAVE LOWER HEALTH STATUS BENEFITS AFTER CORONARY ARTERY BYPASS SURGERY, by Mallik et al.

 
Successful CABG surgery leads to improved survival in selected populations and often dramatic improvement in functional status. Traditional studies of the risk factors for improvement in functional status have focused on measures of diseased severity and comorbid conditions. Mallik et al have studied and documented the impact of preoperative depression. They found that depression is one of the strongest predictors of functional status measured 6 months postoperatively. They suggest that pre- and postoperative treatment of depression be considered to improve the clinical functional result after CABG surgery. See p 271.

	CHOLESTERYL ESTER TRANSFER PROTEIN TaqIB VARIANT, HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS, CARDIOVASCULAR RISK, AND EFFICACY OF PRAVASTATIN TREATMENT: INDIVIDUAL PATIENT META-ANALYSIS OF 13677 SUBJECTS, by Boekholdt et al.

 
The notion that high-density lipoprotein cholesterol (HDL-C) is inversely associated with coronary artery disease risk is firmly established. Moreover, environmental determinants of HDL-C levels are also well described. Despite this knowledge, relatively little is known about the genetic determinants of HDL-C levels and the response to lipid-lowering therapy. The article in this issue by Boekholdt and colleagues helps bridge these gaps in knowledge by investigating a common polymorphism of cholesteryl ester transfer protein in a large, well-characterized population. They found significant associations between CETP genotype and HDL-C that were also linked to coronary artery disease risk. They also provide information on the pharmacogenomic implications of this CETP polymorphism for statin therapy. See p 278.

	VASCULAR ENDOTHELIAL DYSFUNCTION AND MORTALITY RISK IN PATIENTS WITH CHRONIC HEART FAILURE, by Katz et al.

 
Prior studies have shown that patients with heart failure have endothelial dysfunction, and this abnormality could contribute to pathogenesis, symptoms, and long-term outcome. For example, endothelial dysfunction might increase stiffness of the central aorta and increase the hemodynamic load on the left ventricle. In . . . [Full Text of this Article]

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